Sounds like no one has really tried it. The SalSphere product is $388 per kilo. Group buy?
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Another impressive study.
They took apple polyphenols orally and the hair regrowth was surprisingly large, greater than with finasteride!
It's interesting that oral administation has just as much (if not more) of a pro-hair effect than the topical administration. Therefore I have started taking apple polyphenols.
Whats impressive as well that these changes were visible after 2 months already, with decent changes after only 1 month.
NP. I am using the the swanson brand. It has some silica in it ,but it there arent many alternatives at all and its cheap so I went with this one.Very cool Mauritio. Keep us updated.
May i ask where you sourced it/bought it from?
"Specifically, AMSbzs supplement exerted the most important effects, increasing the hair number/cm2 by 125.2% (95% CI: −2.54, P = .0095), the hair weight by 42.1% (95% CI: −3.41, P = .0019), and the keratin content by 40.1% (95% CI: −1.22, P = .0042), at the end of the trial period (Table 2) (Fig. 6). Noteworthy, very significant results were achieved already after 1 month of intervention study."
"It was observed an increase of 6.7 total hairs/0.25 cm2 after 6 months of procyanidin therapy. The same effects have been reported with minoxidil40–42 and finasteride (an inhibitor of type II 5α-reductase, Merck)8 therapy for androgenetic alopecia. In 2% minoxidil treatment, an increase of 250 total hairs/5.1 cm2 (calculated as 12.3 total hairs/0.25 cm2) after 12-month therapy was reported.40 In finasteride treatment (1 mg/day, oral administration), an increase of 86 total hairs/5.1 cm2 (calculated as 4.22 total hairs/0.25 cm2) after 12-month therapy was reported.8 The level of efficacy of 1% procyanidin B2 is concluded to compare favorably with minoxidil and finasteride therapy.15 "
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775114/#B21
With regard to the clinical trial, the AFA supplements used in this study consisted of two different types of gastric-resistant capsules containing (1) AFA polyphenolic extract microencapsulated with maltodextrins (400 mg) (AMS) and (2) AFA polyphenolic extract microencapsulated with maltodextrins (400 mg), biotin (0.20 mg), selenomethionine (80.0 μg), and zinc acetate (21.0 mg), named AppleMetS Hair (AMSbzs).
There are five major groups of polyphenolic compounds found in apples: flavanols (catechin, epicatechin and procyanidins), phenolic acids (mainly chlorogenic acid), dihydrochalcones (phloretin glycosides), flavonols (quercetin glycosides) and anthocyanins (cyanidin)
I tackle hair loss from different angles.So the study used
How much capsules are you taking? Swanson seems to have 125mg per capsule. So you'd need around 4ish capsules 2 times a day yes? Depending on the Source maybe even more as procyanidin content seems to differ from source to source.
I went back on the big reddit thread that discussed procyanidin and i think most people following it came to the conclusion that the amount needed of procyanidin was not feasable money wise. They seemed to went with sulphorophane from broccoli sprouts instead.
However i still think the apple polyphenols in sufficient dosage to provide potential benefits:
While i am not sure how effective anthocyanin from apple is they generally seem to contain anti-fungal properties. Plants seem to increase the amount when stressed/attacked by fungal infections and it is giving plants the purple/blue colour.
Also quercetin similar to ECGC from green tea seems to be used in both the NAD+ boosting department and treatment in lymedisease/coinfection.
How much you would get however from apple polyphenols extract i do not know.
I got them from iherbCan’t find the Swanson procyanidin anywhere
You feel really what?@Mauritio I feel really with taking more apples as well. Btw, ursolic acid is another very promising substance that is in apple skin (apple skin wax).
Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1) - PubMed
Tryptophan hydroxylase 1 (Tph-1) initiates the biosynthesis of peripheral serotonin. As peripheral serotonin suppresses bone formation, inhibitor of Tph-1 provides a useful tool to discover anabolic agents for osteoporosis. In the present study, series of ursolic acid (UA) derivatives were...pubmed.ncbi.nlm.nih.gov
Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis
Really good :)You feel really what?
Nice. Me too, I think it might even lead to weight loss, without trying.Really good :)
I noticed that as well. Weight loss. More stable energy. Better focus than ever. I can read for hours without going into a "distraction (not really worth it) mode" (youtube/social media etc).Nice. Me too, I think it might even lead to weight loss, without trying.
I think the weight loss might be due to its ability to increase UCP1 and the foucse because it increases tyrosine hydroxilase and thus dopamine! How much are you taking and which brand ?I noticed that as well. Weight loss. More stable energy. Better focus than ever. I can read for hours without going into a "distraction (not really worth it) mode" (youtube/social media etc).
Cool, let me know how it goes. I really like it. It does seem to help my gallbladder as well, which I had problems with for the last 2 months. the only issue is that is a bit underdosed and contains silica, but Im going to order a few more bottles for sure.This is a very interesting thread. I have always been compelled to eat apples and apple juice/apple cider have always been favorites of mine. Please keep this thread going. I’m gonna try out that Swanson product that was mentioned up-thread.
Theoretically eating an apple should give you the same amount of polyphenols as one capsule, but I get benefits from taking the supplement that I dont get from eating an apple or even two.@Mauritio Do you have any idea if eating (a lot of) apples might give the same benefits?