viewtopic.php?f=10&t=249&p=1773#p1773
Ray Peat said:"Bihari thinks naltrexone works by increasing endorphins, I think excess endorphins are often the problem, and the antagonist can sometimes be helpful. The endorphins differ in their effects on the two sides of the body, so when I knew two women (within the same year) who had been having mysterious one-sided symptoms for a few months before discovering that they had ovarian cancer (on the same side), I thought that the endorphins were probably involved, maybe to suppress pain on that side. Naloxone and naltrexone have some effects that aren't directly related to the endorphins, on estrogen and histamine."