Skyhigh 25,OHD from D3 supplement

[Mauritio]

Q:Hello Mr. Peat,
What do you think is the optimal amount of days before a vitamin D test ,to stop supplementation? Or should we stop at all ?

A:The day before is o.k.

---------

Q: Hello Mr. Peat,
I recently started juicing oranges and other fruits .
I was wondering if you juice oranges or other fruits yourself and if so which kind of oranges do you prefer?
I have read that the oranges from Valencia, Spain are supposed to be the best ,do you think that's true ?

A:They are usually good; I use any that are sweet and juicy.

 

[youngsinatra]

In my experience 1000 IU usually raise blood levels by 5 ng/ml - and if all co-factors (K2, magnesium, boron) are in place and retinol intake is below 5000 IU/d it can be as high as 10 ng/ml per 1000 IU.

 

[xeliex]

I have a similar experience with highs and lows but settled on 8000 iu daily.

Large daily doses can quickly bring the lab value up. But from experience with patients, very high lab values tend to plummet quickly when large intake stops. So stop, but recheck and get on a maintenance dose.

I too feel better with higher levels and higher intake.

The stopping before testing thought is an interesting one, but since daily supplementing is the current state of being, I think I will continue testing without stopping the supplementation. But now that is more of an philosophical issue

Yes, I tested a lot. 15k iu pushed my levels up pretty quickly and I was borderline hypercalcemic. It is expected I think as large doses get converted quickly to 1,25 hydroxyvitamin D.

Yes, I typically only stop 1 day before checking levels.

 

[youngsinatra]

Yes, I tested a lot. 15k iu pushed my levels up pretty quickly and I was borderline hypercalcemic. It is expected I think as large doses get converted quickly to 1,25 hydroxyvitamin D.

Yes, I typically only stop 1 day before checking levels.

You got to 75ng/ml with 15K IU/d, right? That should be nowhere near of what should cause hypercalcemia. (usually at 150ng/ml and above it causes this)

But if calcium intake is high then it can cause hypercalcemia.
Did you consume lots of dietary calcium or took calcium supplements at that time too?

 

[baccheion]

Sunlight ("tanning") can reduce 25(OH)D. Same with maintaining the right serum ratio of vitamin A : vitamin D. Perhaps it makes sense that magnesium, vitamin K2, riboflavin??, etc can also do the same as they increase conversion to calcitriol. Either way, they help balance against side effects.

 

[Peatness]

Frome this article
On the other hand, multiple enzymes in the biosynthetic pathway of vitamin D are riboflavin-dependent enzymes, thus, riboflavin exerts its indirect anti-inflammatory activity via its essential role in vitamin D synthesis, which has a potent anti-inflammatory activity.

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

With the huge negative impact of neurological disorders on patient’s life and society resources, the discovery of neuroprotective agents is critical and cost-effective. Neuroprotective agents can prevent and/or modify the course of neurological ...

www.ncbi.nlm.nih.gov

Vitamin B2 (riboflavin) is needed to process vitamin D – March 2014 | VitaminDWiki

Science-based Vitamin D

vitamindwiki.com

 

[Mauritio]

Frome this article
On the other hand, multiple enzymes in the biosynthetic pathway of vitamin D are riboflavin-dependent enzymes, thus, riboflavin exerts its indirect anti-inflammatory activity via its essential role in vitamin D synthesis, which has a potent anti-inflammatory activity.

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

With the huge negative impact of neurological disorders on patient’s life and society resources, the discovery of neuroprotective agents is critical and cost-effective. Neuroprotective agents can prevent and/or modify the course of neurological ...

www.ncbi.nlm.nih.gov

Vitamin B2 (riboflavin) is needed to process vitamin D – March 2014 | VitaminDWiki

Science-based Vitamin D

vitamindwiki.com

Very interesting. Thanks!
There is a similar correlation between magnesium and vitamin D levels . So supplementing B2+Mag might help if someone can't get their Vitamin D level up.

 

[Shackles]

Very interesting. Thanks!
There is a similar correlation between magnesium and vitamin D levels . So supplementing B2+Mag might help if someone can't get their Vitamin D level up.

Maybe you have bacteria which produce B2 for you

 

[Gustav3Y]

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

If only B2 would not induce headaches and migraines for me every time I take it.

 

[InChristAlone]

Maybe you have bacteria which produce B2 for you

We are definitely made to rely on our gut microbiome for a continual supply of b vitamins. Unfortunately many people don't have that supply from the wrong gut bacteria. So they need to flood the gut with b vitamins for a while to get them back. I wish I could do this though, I get severe blood sugar problems from supplementing many of the b vitamins.

 

[Peatness]

If only B2 would not induce headaches and migraines for me every time I take it.

Do you get enough salt?

 

[Gustav3Y]

And I've been supplementing 2-3000IU/ day for like a year . So I'm going to increase it to 5000IU/ day and check again in 2 months.

I've tried 1-2K before and resulted in nothing.
Increase only happened when I went 8-10K per day and in 1 month the result was that it doubled, I've been using Mg too.

 

[Gustav3Y]

Do you get enough salt?

What does enough mean?
I eat salt, if that is the question.

 

[Mauritio]

I've tried 1-2K before and resulted in nothing.
Increase only happened when I went 8-10K per day and in 1 month the result was that it doubled, I've been using Mg too.

Yeah I'll try 5k first and if it doenst move over 35 I'll go for 8-10k IU .

 

[xeliex]

You got to 75ng/ml with 15K IU/d, right? That should be nowhere near of what should cause hypercalcemia. (usually at 150ng/ml and above it causes this)

But if calcium intake is high then it can cause hypercalcemia.
Did you consume lots of dietary calcium or took calcium supplements at that time too?

Yes, calcium consumption is always relatively high, but I think it's the acute phase of the D increase that might have spurred a temporary rise in 1,25 hydroxy. But it's all speculation,especially since the pth was still not maximally suppressed despite the phosphorus being relatively low.

 

[xeliex]

Georgi has spoken before about people unable to increase their levels benefiting from naval application.

From my experience with working with sick people, obesity requires more to replete and very high doses need a maintenance dose since they tend to decline fast.

 

[Shackles]

We are definitely made to rely on our gut microbiome for a continual supply of b vitamins. Unfortunately many people don't have that supply from the wrong gut bacteria. So they need to flood the gut with b vitamins for a while to get them back. I wish I could do this though, I get severe blood sugar problems from supplementing many of the b vitamins.

more interesting would be why many have an increased need for certain vitamins. If it is about them forming enzymes, then how come? Are those enzymes one time use then dead or are there things which actively destroy those enzymes? Or maybe you need more of those because of specialised needs?

 

[InChristAlone]

more interesting would be why many have an increased need for certain vitamins. If it is about them forming enzymes, then how come? Are those enzymes one time use then dead or are there things which actively destroy those enzymes? Or maybe you need more of those because of specialised needs?

To make repairs each night. We are self healing. But not if we can't get into deep sleep for long enough and not unless we have a continuous supply of b vitamins and neurotransmitters from our gut.

 

[InChristAlone]

So other people can follow along, this is where I learned about it:

 

[Peatness]

What does enough mean?
I eat salt, if that is the question.

Judging by the irritated tone of this response I suspect you need more salt. B2 can cause dehydration

Dehydration and Salt Deficiency Trigger Migraines- Hormones Matter

Could dehydration and salt deficiency be the cause of migraines? New theory suggests, yes.

www.hormonesmatter.com