redsun
Member
- Joined
- Dec 17, 2018
- Messages
- 3,013
Hi. Yes, I realized that I had vitamin deficiencies afterwards and took steps to tackle it. I take folic acid,b12 and I've tried all the b vitamins at one time or other, including riboflavin.
When it comes to copper, a hair mineral test gave me a low score but suggested I had hidden toxicity.
I'm definitely in a high serotonin state I think; just taking inositol really crashed my cognition previously and gave me terrible muscle spasms which still plague me.
Does histamine help to control sympathetic nerve tone? That test I took also suggested I was stuck in a parasympathetic state.
I'm looking chiefly at histamine due to my symptoms, that past window, and the fact it acts as a huge neuromodulator which can impact other systems. Also the fact I don't show flu symptoms normally.
I don't think it's as simple as just increasing histamine though.
I'm looking at the H3 receptor as a possible culprit given its complex role in the brain. For instance, I learnt that H3 receptors exert control over dopamine receptors, which is pretty big.
"Hidden" toxicity of copper is nonsense if it is showing low on the hair test its likely good or even low.
Histamine is very excitatory, it increases wakefulness and is very stimulating.
Copper is also stimulating even though its considered anti-histamine via DAO but the relationship between copper and estrogen and the fact that estrogen is also excitatory to the brain on its own and that mast cells have estrogen receptors on them shows its not that simple.
High serotonin state will keep you in a low thyroid, low energy (low sympathetic) type state. Thats where copper can possibly affect this positively by increasing its breakdown. Too much of course isnt good either. Zinc is important to creating more histamine but if zinc intake has never been a problem forcing more zinc in will increase histamine synthesis but its sedating by lowering iron and copper levels over time.
Usually people with higher thyroid will have more histamine:
Thyroid Hormone, Thyroid Hormone Metabolites And Mast Cells: A Less Explored Issue
What may be less of an issue of having too much copper, is that the levels of iron and copper imbalanced in the body. In other words iron levels could be too low, and low iron status will lead to low thyroid (lower T3) and thus lower histamine, but also lower catecholamines and other neurotransmitters will suffer as well all because thyroid is low because iron is lacking. Low copper and also cause low thyroid, as can low zinc, etc...
How much brain "energy" and "speed" you have is dependent on how well your histamine, glutamate, dopamine, noradrenaline, acetylcholine systems etc... are working, and these systems are heavily dependent on a good energy metabolism and good antioxidant system because nothing is free. It costs resources and increases oxidative stress to force neurotransmitters up too much without your antioxidation and energy metabolism being in a good place.
So histamine is a big part of a well-functioning CNS but there are many relationships between all these neurotransmitters so there's a lot to look at that may need to be paid attention to.