I know there are several Ray quotes on his suggested usage of T4 in congregation with T3. I have seen him say that many people like to use T3 throughout the day and rely on the use of a T3/T4 combo to get them through the night, particularly in the winter months. I have also seen him suggest taking 1/8 cynoplus (T3/T4) combo 2x a day. I was wondering what most people on here have had the most success with. I have recently for the first time tried taking Cynoplus twice a day (Once in AM & Once in PM.) Results have been decent at best. I think I prefer taking T3 as needed, an relying on T3/T4 combo at night to keep TSH at bay/stress hormones low. I know that Nathan Hatch is against using T4 entirely.