Hey everyone,
I have been working to figure out the cause of baldness. I think it is a systemic issue. @haidut and @Travis posts have helped me immensely as well as Danny Roddy's work. Here is an email I sent to Danny this morning. It is a fluid hypothesis. Let me know what you think.
Hey Danny,
I contacted you on youtube. I continued to work out the pieces of the baldness theory I was describing and I wanted to lay them out for you here. Your work has helped me a ton and you have a global understanding of the phenomena so I thought it best to share with you.
1) TLR4 activation leads to fibrosis in the body. It is activated by endotoxin, indicating dysbiosis with gram negative bacteria: Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease. - PubMed - NCBI
Endothelial cell Toll-like receptor 4 regulates fibrosis associated angiogenesis in liver
Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study
2) Gut dysbiosis leads to up regulation of hpta axis thus cortisol, DHEA, aldosterone:
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
3) Dhea is preferentially converted to DHT in the body: DHEA Is Preferentially Converted Into DHT In Humans
4) In baldness the scalp is fibrosed (i.e. the galea)
4) the baldness field follows the galea aponeurotic almost perfectly.
5) the bald scalp has decreased blood flow:
Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. - PubMed - NCBI
Subcutaneous blood flow in early male pattern baldness. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/2365903
6) The pattern of hair loss follows the mechanical "tight spots" of the galea aponeurotic. Meaning fibrosis and tightening of the galea enhances baldness by increasing hypoxia.
7) in hypoxia DHT is up regulated in the scalp:
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=105159
With all of this I propose that baldness is caused by gut dysregulation leading to adrenal up regulation and fibrosis/ inflammation throughout the body. The fibrosis effects the galea leading to decreased blood supply and drainage causing hypoxia. This up regulates 5-AR in the scalp leading to increased DHT. the adrenal up regulation provides the DHEA that is preferentially converted to DHT leading to the high concentrations in skin throughout the body (i.e. the chest hair and body hair seen often with baldness). The cortisol and aldosterone also have negative impacts on hair: https://raypeatforum.com/community/...caused-by-immune-imbalance.19983/#post-281775. T-regs dependent upon the gut flora, also participate in hair regrowth.
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additions for ray peat forum:
treatments:
1) ketotifen maybe?? (a tlr4 antagonist)
2) raw kefir + raw milk + phages to adjust micro biome
3) vit c to help with adjusting collagen
4) scalp massage
5) red light
6) inversion to increase blood flow
the connection to prostate cancer and heart disease is discussed in this post as well as studies below:
https://raypeatforum.com/community/...ncer-and-may-even-treat-it.20341/#post-282021
also note these studies
TLR4 and heart disease connection:
https://www.ncbi.nlm.nih.gov/pubmed/17100625
chronic prostatatis/ prostate cancer and gut dysbiosis:
https://www.ncbi.nlm.nih.gov/pubmed/28217695
https://www.nature.com/articles/srep27051
all of this also goes hand in hand with peats work and shows the connection between high prolactin and MPB: https://raypeatforum.com/community/...etric-for-serotonin-and-estrogen-levels.3594/
gut dysbiosis= high serotonin/ estrogen= elevated prolactin
also shows the low vitamin D status in male pattern baldness:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176535/
immune function= increased vit d usage= vit D depletion= effected immune regulation= dysbiosis= the cycle continues.
I have been working to figure out the cause of baldness. I think it is a systemic issue. @haidut and @Travis posts have helped me immensely as well as Danny Roddy's work. Here is an email I sent to Danny this morning. It is a fluid hypothesis. Let me know what you think.
Hey Danny,
I contacted you on youtube. I continued to work out the pieces of the baldness theory I was describing and I wanted to lay them out for you here. Your work has helped me a ton and you have a global understanding of the phenomena so I thought it best to share with you.
1) TLR4 activation leads to fibrosis in the body. It is activated by endotoxin, indicating dysbiosis with gram negative bacteria: Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease. - PubMed - NCBI
Endothelial cell Toll-like receptor 4 regulates fibrosis associated angiogenesis in liver
Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study
2) Gut dysbiosis leads to up regulation of hpta axis thus cortisol, DHEA, aldosterone:
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems
3) Dhea is preferentially converted to DHT in the body: DHEA Is Preferentially Converted Into DHT In Humans
4) In baldness the scalp is fibrosed (i.e. the galea)
4) the baldness field follows the galea aponeurotic almost perfectly.
5) the bald scalp has decreased blood flow:
Transcutaneous PO2 of the scalp in male pattern baldness: a new piece to the puzzle. - PubMed - NCBI
Subcutaneous blood flow in early male pattern baldness. - PubMed - NCBI
https://www.ncbi.nlm.nih.gov/pubmed/2365903
6) The pattern of hair loss follows the mechanical "tight spots" of the galea aponeurotic. Meaning fibrosis and tightening of the galea enhances baldness by increasing hypoxia.
7) in hypoxia DHT is up regulated in the scalp:
http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=105159
With all of this I propose that baldness is caused by gut dysregulation leading to adrenal up regulation and fibrosis/ inflammation throughout the body. The fibrosis effects the galea leading to decreased blood supply and drainage causing hypoxia. This up regulates 5-AR in the scalp leading to increased DHT. the adrenal up regulation provides the DHEA that is preferentially converted to DHT leading to the high concentrations in skin throughout the body (i.e. the chest hair and body hair seen often with baldness). The cortisol and aldosterone also have negative impacts on hair: https://raypeatforum.com/community/...caused-by-immune-imbalance.19983/#post-281775. T-regs dependent upon the gut flora, also participate in hair regrowth.
------------------------------------------------------------------------------------------------------------------------------
additions for ray peat forum:
treatments:
1) ketotifen maybe?? (a tlr4 antagonist)
2) raw kefir + raw milk + phages to adjust micro biome
3) vit c to help with adjusting collagen
4) scalp massage
5) red light
6) inversion to increase blood flow
the connection to prostate cancer and heart disease is discussed in this post as well as studies below:
https://raypeatforum.com/community/...ncer-and-may-even-treat-it.20341/#post-282021
also note these studies
TLR4 and heart disease connection:
https://www.ncbi.nlm.nih.gov/pubmed/17100625
chronic prostatatis/ prostate cancer and gut dysbiosis:
https://www.ncbi.nlm.nih.gov/pubmed/28217695
https://www.nature.com/articles/srep27051
all of this also goes hand in hand with peats work and shows the connection between high prolactin and MPB: https://raypeatforum.com/community/...etric-for-serotonin-and-estrogen-levels.3594/
gut dysbiosis= high serotonin/ estrogen= elevated prolactin
also shows the low vitamin D status in male pattern baldness:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176535/
immune function= increased vit d usage= vit D depletion= effected immune regulation= dysbiosis= the cycle continues.