ddjd
Member
- Joined
- Jul 13, 2014
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I was having some problems with kidney soreness recently so I started taking Trimethylglycine (TMG) daily and noticed as well as reducing my kindey pain considerably, my dandruff also completely cleared up.
Since TMG is an osmolyte, it can keep hair cells hydrated and protect against environmental damage. As an osmolyte/osmoprotectant, TMG keeps cells hydrated and increases stress resilience. It can stabilize proteins and membranes when environmental conditions are bad, such as drought, low temperatures. This might explain why its protective to the scalp.
One other theory of mine is that undermethylation could be the reason for the chronic dandruff, as methyl groups are required to excrete estrogen.
As some of you will know TMG is a methyl donor and stimulates the BHMT pathway. BHMT (Zinc-dependent Betaine Homocysteine Methyl Transferase) directly methylates homocysteine back in to methionine, serving as a “back door” pathway to “pull” homocysteine away from the CBS “sulfate drain”. Thus if you bear CBS or BHMT abnormalities, it makes sense to support BHMT function. TMG can be utilized if you are not overly sensitive to methyl group supplementation. The BHMT pathway is particularly active in the liver and the kidney, which are the main organs that store large amounts of betaine. In the liver, BHMT catalyzes up to 50% of homocysteine metabolism.
I've also been taking a lot of Zinc gluconate, thiamine, Folinic acid (not to be confused with Folic Acid), Methyl b12, recently, so I wonder if TMG's interaction with one of these supplements might also be responsible for the disappearance of my dandruff.
Studies on TMG:
"TMG also increased antioxidant levels, which protects against oxidative damage [R]."
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. - PubMed - NCBI
Since TMG is an osmolyte, it can keep hair cells hydrated and protect against environmental damage. As an osmolyte/osmoprotectant, TMG keeps cells hydrated and increases stress resilience. It can stabilize proteins and membranes when environmental conditions are bad, such as drought, low temperatures. This might explain why its protective to the scalp.
One other theory of mine is that undermethylation could be the reason for the chronic dandruff, as methyl groups are required to excrete estrogen.
As some of you will know TMG is a methyl donor and stimulates the BHMT pathway. BHMT (Zinc-dependent Betaine Homocysteine Methyl Transferase) directly methylates homocysteine back in to methionine, serving as a “back door” pathway to “pull” homocysteine away from the CBS “sulfate drain”. Thus if you bear CBS or BHMT abnormalities, it makes sense to support BHMT function. TMG can be utilized if you are not overly sensitive to methyl group supplementation. The BHMT pathway is particularly active in the liver and the kidney, which are the main organs that store large amounts of betaine. In the liver, BHMT catalyzes up to 50% of homocysteine metabolism.
I've also been taking a lot of Zinc gluconate, thiamine, Folinic acid (not to be confused with Folic Acid), Methyl b12, recently, so I wonder if TMG's interaction with one of these supplements might also be responsible for the disappearance of my dandruff.
Studies on TMG:
"TMG also increased antioxidant levels, which protects against oxidative damage [R]."
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. - PubMed - NCBI
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