Okay, so I shared this study on a small Discord server and it got quite some engagement. One day later, I got told by somebody in the same Discord server that a real life friend of theirs shared to them the same study. Just what are the odds?
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Junk science?No............no they don't.
That's why they call it "junk".
Over 2000 views in 18 hours.This thread will have the highest views soon, lol.
Junk science?
Gotcha! It was just a play with words regarding the article.
Which is a cofactor for vitamin V.Some vitamin dee-k to get to that sweet sweet vitamin P.
HGH/IGF-1 is relevant as the growth factor. DHT works primarily due to the rise in PGE1/3:E2 ratio and the resulting vasodilation. It is a combination of growth factors and androgens for reasons already stated. It has been said that the DHT fueling penis growth comes from skin (ie, 5-AR 1).
Vitamin D (active form) is believed to work in this regard, as VDR exists commonly with androgen receptors (AR). The active form is both associated with osteocalcin (androgenic action IIRC) and with agonism of relevant receptors in the penis. Further, it supposedly results in longer binding of androgens to AR.
Some vitamin dee-k to get to that sweet sweet vitamin P.
Which is a cofactor for vitamin V.
Over 2000 views in 18 hours.
I didn't say anything about just hGH. hGH/IGF-1 + androgens. Androgens stimulates/shape and hGH triggers overall growth.Sure, I agree on the effects of vitamin D being through the androgen receptor and potentiating of androgens. The Calcirol OP has some info on that.
Calcirol - Liquid Vitamin D3
I am not convinced about the role of prostaglandins and hGH though. Animals raised on EFA diets (= zero prostaglandins) do not get micropenis, actually to the contrary they have very high androgenic tone. hGH/IGF-1 are related to higher estrogen levels, and DHT is known to actually lower both, but IGF-1 more potently than hGH. Only aromatizable androgens tend to raise hGH/IGF-1.
Europe PMC
The studies on people with micropenis show that the effects of hGH are through increasing endogenous androgens.
Penile growth in response to hormone treatment in children with micropenis
Using only hGH is probably warranted only in cases where there is hypopituitarism and as such other concurrent issues such as dwarfism. Micropenis in the presence of normal height/development is solidly linked to hypogonadism, 5-AR deficiency, or some sort of androgen insensitivity and the most appropriate treatment is DHT or higher dose T (invariably used topically in studies, probably because it converts to DHT more).
Finally, adults with micropenis have been successfully treated with DHT monotherapy and their hGH levels are low (if they are healthy). Prostaglandins may play a role in vasodilation and erection but I have not seen any evidence that the prostaglandins play a role in increasing the length/width of adult penis.
Transdermal Dihydrotestosterone Therapy and its Effects on Patients with Microphallus - ScienceDirect
Just my 2c.
If you look at males with aromatase deficiency, micropenis is strong
Yeah but do they scar or cause harm ?We should not underestimate the effect of vacuum pumps, I read that these pumps are the only efficient intervention for enlargement apart of surgery.
We should not underestimate the effect of vacuum pumps, I read that these pumps are the only efficient intervention for enlargement apart of surgery.