Luann
Member
- Joined
- Mar 10, 2016
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These are the two I'm talking about.
Development of hepatic steatosis and essential fatty acid deficiency in rats with hypercaloric, fat-free parenteral nutrition — UC Davis
"..hepatic essential fatty acid deficiency (EFAD) developed by day 4; liver linoleic acid levels had dropped from 20 to 1% of total fatty acids, and liver triene:tetraene ratio was 0.68. Similar changes in hepatic phospholipid fatty acids were observed."
EFA Deficiency Achievable In 2 Weeks On Fat Free Diet
"EFA deficiency was detected by decreases in linoleic acid and by the appearance of 5, 8, 11-eicosatrienoic acid in lipid fractions of plasma. Linoleic acid decreased significantly during 2 wk of the fat-free diet given intravenously from 48.8 to 9.8% (percent of total fatty acids) in cholesterol esters, from 21.2 to 3.2% in phospholipids, from 9.6 to 2.0% in free fatty acids, and from 14.1 to 2.6% in triglycerides. Eicosatrienoic acid, normally undetectable, appeared..."
I thought the rats might have really cleared most of the PUFA in their body in four days, since they grew up on chow rather than the standard western diet. But the humans couldn't have, even in two weeks. What caused PUFA levels to drop so low in both groups? Were the fatty acids hiding elsewhere?
Development of hepatic steatosis and essential fatty acid deficiency in rats with hypercaloric, fat-free parenteral nutrition — UC Davis
"..hepatic essential fatty acid deficiency (EFAD) developed by day 4; liver linoleic acid levels had dropped from 20 to 1% of total fatty acids, and liver triene:tetraene ratio was 0.68. Similar changes in hepatic phospholipid fatty acids were observed."
EFA Deficiency Achievable In 2 Weeks On Fat Free Diet
"EFA deficiency was detected by decreases in linoleic acid and by the appearance of 5, 8, 11-eicosatrienoic acid in lipid fractions of plasma. Linoleic acid decreased significantly during 2 wk of the fat-free diet given intravenously from 48.8 to 9.8% (percent of total fatty acids) in cholesterol esters, from 21.2 to 3.2% in phospholipids, from 9.6 to 2.0% in free fatty acids, and from 14.1 to 2.6% in triglycerides. Eicosatrienoic acid, normally undetectable, appeared..."
I thought the rats might have really cleared most of the PUFA in their body in four days, since they grew up on chow rather than the standard western diet. But the humans couldn't have, even in two weeks. What caused PUFA levels to drop so low in both groups? Were the fatty acids hiding elsewhere?