Any ideas? Are there any downsides to having surgery to remove the gallbladder (cholecystectomy) for this problem, if there are a lot of hardened stones (“porcelain gallbladder” is the diagnosis) that sometimes cause pain?
Saw this, from RP:
Ray Peat Email Advice Depository
Saw this, from RP:
I asked Ray about treating gallstones, aspirin appears to have still more tricks up its sleeve;
Ray Peat said:
I think keeping the hormones in balance, with good thyroid function, is the basic thing. Aspirin is probably helpful.
Dig Dis Sci. 1995 Aug;40(8):1782-5.
Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage schedules.
Das A, Baijal SS, Saraswat VA.
Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study protocol in 20 healthy volunteers and 30 patients with gallstone disease. Healthy volunteers had a higher ejection fraction compared to patients with gallstone disease (73.9 +/- 0.9% vs 60.4 +/- 1.0%, P < 0.05). Aspirin in a dose of 350 mg/day for two weeks did not alter gallbladder motility in the healthy volunteers. Thirty patients with gallstone disease were randomized into three treatment groups: group I (placebo), group II (aspirin 350 mg/day), and group III (aspirin 1400 mg/day). After two weeks of treatment, gallbladder ejection fraction was improved in group II (74.0 +/- 1.7% vs 62.0 +/- 1.7%, P < 0.01) and group III (69.8 +/- 3.8% vs 61.2 +/- 1.3%, P < 0.01) but not in group I (60.4 +/- 2.6% vs 59.0 +/- 1.9%, P = NS). The higher dose of aspirin did not induce a greater increase in gallbladder emptying. It is concluded that impaired gallbladder motility in patients with gallstone disease is corrected by short-term oral aspirin even in low dosage. This may be clinically useful in secondary prophylaxis after nonsurgical therapy for gallstone disease.
Ray Peat Email Advice Depository