Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors - ScienceDirect
Highlights
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5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into DHT.
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We found that 5αR2 knockout (KO) mice have reduced dominance-related behaviors.
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These deficits are accompanied by lower novelty-seeking and risk-taking.
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5αR2 KO mice exhibit reduced D2-like receptor binding in the nucleus accumbens.
Highlights
•
5α-reductase 2 (5αR2) catalyzes the conversion of testosterone into DHT.
•
We found that 5αR2 knockout (KO) mice have reduced dominance-related behaviors.
•
These deficits are accompanied by lower novelty-seeking and risk-taking.
•
5αR2 KO mice exhibit reduced D2-like receptor binding in the nucleus accumbens.
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