The compound erinacine in lion's mane is a kappa receptor agonist. This isn't that terrible of a thing but it will produce an uncomfortable dysphoria in higher doses. I've tried lion's mane on many occasions but can't quite get past the dysphoria (its very intense for me). That being said I'm sure some extracts are stronger than others regarding this effect.
Ah, I see thanks. You have any knowledge on chaga? Peat thinks it is fine, but that is my second fav from cordyceps. I think it is safe.