According to this study Vit A increases, not decreases Aromatase activity

[Elie]

Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor α - PubMed

Estrogen synthesis in adipose tissue is associated with the development of breast cancer. Tumors are preferentially found in breast quadrants with strongest expression of the cytochrome P450 aromatase (encoded by the gene CYP19A1). Several promoters regulated by various hormonal factors drive...

pubmed.ncbi.nlm.nih.gov

The looked at the effect of vit A on aromatase in breast tissue fibroblasts.

I'd like to know if anyone has reasonable objections based on study design, methodology etc.

 

[GorillaHead]

Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor α - PubMed

Estrogen synthesis in adipose tissue is associated with the development of breast cancer. Tumors are preferentially found in breast quadrants with strongest expression of the cytochrome P450 aromatase (encoded by the gene CYP19A1). Several promoters regulated by various hormonal factors drive...

pubmed.ncbi.nlm.nih.gov

The looked at the effect of vit A on aromatase in breast tissue fibroblasts.

I'd like to know if anyone has reasonable objections based on study design, methodology etc.

I actually believe that. My nipples felt more tender after supplementing A.

 

[Peater]

Aromatase activity induction in human adipose fibroblasts by retinoic acids via retinoic acid receptor α - PubMed

Estrogen synthesis in adipose tissue is associated with the development of breast cancer. Tumors are preferentially found in breast quadrants with strongest expression of the cytochrome P450 aromatase (encoded by the gene CYP19A1). Several promoters regulated by various hormonal factors drive...

pubmed.ncbi.nlm.nih.gov

The looked at the effect of vit A on aromatase in breast tissue fibroblasts.

I'd like to know if anyone has reasonable objections based on study design, methodology etc.

Great find Elie. As I understand it, the "Low VA" approach thinks it gets shuttled to body fat (Like PUFAs) when the liver is at capacity, so it is feasible it would be present in adipose tissue.

 

[Clyde]

Things like this make my head spin. Retinoic Acid is a chemo drug. You would think it would grow cancer if it increased aromatase

Vitamin A (retinol) Inhibits Aromatase

I mentioned this in my other posts but wanted to post at least one direct study for those interested in the vitamin A anti estrogenic effect: Retinol inhibits aromatase activity and expression in vitro. - PubMed - NCBI "...Aromatase converts androgens into estrogens and is thought to supply a...

raypeatforum.com

Retinol inhibits aromatase activity and expression in vitro - PubMed

Aromatase converts androgens into estrogens and is thought to supply a local source of estrogen that facilitates the growth of hormone-responsive tumor cells. Inhibition of aromatase is therefore an important chemopreventive strategy. We investigated the effect of retinol and selected retinoids...

pubmed.ncbi.nlm.nih.gov

 

[GorillaHead]

y’all understand that these things don’t just work in one way. Biphasic effects. Duration. Dosage. Types of cell. Vitro. Vivo all these factors have profound effects on what retinol may do. And yes we can make conjecture from this data. But honestly the only way we can truly find out what’s up is if we could run these cell based studies in real time on humans somehow. But we can’t really. We usually use indicators like serum hormones and what not. Even That often doesn’t mean much

 

[lamassu]

I appreciate you rationally posting studies with simple commentary.

I suppose this finding could be considered as expected for a highly unsaturated molecule. I'd be interested in seeing a dose/concentration response relationship for this effect