Highserotonin90
Member
- Joined
- Mar 24, 2018
- Messages
- 805
@youngsinatra Correct clarification, thanks!
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Copper is also the main factor to reducing intracellular histamine, as HNMT is a copper enzyme too.Copper only degrades histamine in the digestive tract, from food sources. (via DAO)
Methylation (SAMe) degrades intracellular histamine. (via HNMT)
Do you think that elevated ach could further impair metabolism in people like us?Thyroid, coffee and low-dose biotin are the only things that seems to help. And avoiding pro-cholinergic substances/foods (B vitamins usually bite me in the **** after a few days)
Acetylcholine in excess can raise nitric oxide (NO), which can react with oxygen and create peroxynitrite (ONOO) which then *irreversibly* inhibits oxidative phosphorylation and many enzymes in energy metabolism. I think lowering NO might help.Do you think that elevated ach could further impair metabolism in people like us?