Mossy
Member
- Joined
- Jun 2, 2017
- Messages
- 2,043
This is specifically my point of interest in it, now, verses for working out.I would argue that its a good way to help attenuate sepsis. I just have a paranoia regarding sepsis so I supplement this daily.
Citrulline: just a biomarker or a conditionally essential amino acid and a pharmaconutrient in critically ill patients?
"In the previous issue of Critical Care, Ware and colleagues [1] showed that citrulline (CIT) plasma levels are extremely low in critically ill patients with sepsis and significantly lower in patients complicated with acute respiratory distress syndrome (ARDS). Thus, this study brings the new and important information that CIT depletion may be related to morbid events. In addition, these data form a strong rationale for CIT supplementation in intensive care unit (ICU) patients with sepsis."
"For a long time, CIT was considered just a 'garbage' amino acid because it is not included in proteins and is known only as an intermediary in the urea cycle. However, some early classic studies suggested that CIT had a unique metabolism and that its deficiency might be harmful (reviewed recently in [2]). The fact that CIT is almost absent from food (with the notable exception of watermelon) and is synthesized solely by the gut at the whole body level led Crenn and colleagues [3] to hypothesize, and then prove, that CIT plasma level is a reliable marker of intestinal functional mass. "
"I do not know of any data that establish, at the cellular level, that ARG is a better precursor of nitric oxide (NO) than CIT or vice versa. In addition, in vitro data suggest that the ability of ARG or CIT to generate NO in macrophages (which play a key role in sepsis and ARDS) is co-regulated by glutamine [13], whose availability is decreased in sepsis. In the case of sepsis, we cannot safely speculate, because, on the one hand, it is true that **** + ASL and NOS channel CIT, but on the other hand, the ARG transporter CAT2 (cationic amino acid transporter 2) is also connected to inducible NOS, and both are overexpressed in sepsis [14]. The absence of any difference in ARG levels between patients with ARDS and those without it apparently supports the authors' view that the key is CIT, not ARG. However, the absence of any correlation between amino acids and NO end-products (that is, nitrate + nitrate) supports the idea that the answer is in the lung, not in the plasma, and that - in the absence of measurements with stable isotopes, arterio-venous difference, and measurements in the bronchoalveolar fluid - all these considerations are just a matter of speculation.
I’ve been having what I would define as breathing/respiratory issues, as well as a sensitive/weak heart. So, your post, and @Vinero’s, caught my interest. The thought that really hit me is maybe a pro-Peat diet might be so anti-N.O., that for those in poor health, or with susceptibilities (as in your case g), there could be some exceptions to the rules. It’s at least worth consideration and investigation.