Such_Saturation
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- Nov 26, 2013
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Even if you try an agonist combo it will still have to compete with the cyproheptadine.
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Makrosky said:post 99022It will release dopamine but you receptors for it will be blocked by cypro so I am not sure this will work. Probably they won't be so much blocked so trying the combo seems legit.Such_Saturation said:post 97356 It will release dopamine into your brain. You can check many reports on various forums. But definitely something you don't want to overdo.
haidut said:post 99027Makrosky said:post 99022It will release dopamine but you receptors for it will be blocked by cypro so I am not sure this will work. Probably they won't be so much blocked so trying the combo seems legit.Such_Saturation said:post 97356 It will release dopamine into your brain. You can check many reports on various forums. But definitely something you don't want to overdo.
As far as I can tell, at reasonable concentrations (8mg or less in a single dose) cyproheptadine is only antagonistic to the D3 receptor. Taking it with 1mg - 2mg bromocriptine should favor D3 agonism as the affinity of bromocriptine for D3 is stronger than cyproheptadine's.
Makrosky said:post 99102haidut said:post 99027Makrosky said:post 99022It will release dopamine but you receptors for it will be blocked by cypro so I am not sure this will work. Probably they won't be so much blocked so trying the combo seems legit.Such_Saturation said:post 97356 It will release dopamine into your brain. You can check many reports on various forums. But definitely something you don't want to overdo.
As far as I can tell, at reasonable concentrations (8mg or less in a single dose) cyproheptadine is only antagonistic to the D3 receptor. Taking it with 1mg - 2mg bromocriptine should favor D3 agonism as the affinity of bromocriptine for D3 is stronger than cyproheptadine's.
Good to know haidut! Thanks! Would there be another way of achieving that without using an extra pharma drug like bromocriptine?
haidut said:Definitely cyproheptadine. As far as I know mirtazapine was specifically developed to NOT have the anticholinergic effects of cypro.
haidut said:Choline is excitotoxic in high doses, and Peat has written about it. A few years ago cholinergic drugs were expected to cure Alzheimer's but ended up as complete failure. It is the anticholinergic drugs (like cypro) that improve memory and neurogenesis.
Parsifal said:post 99710haidut said:Choline is excitotoxic in high doses, and Peat has written about it. A few years ago cholinergic drugs were expected to cure Alzheimer's but ended up as complete failure. It is the anticholinergic drugs (like cypro) that improve memory and neurogenesis.
How come that marijuana impairs short term memory if anti-cholinergic drugs are good for memory?
Fletcher said:post 99423 My experience = I tried Cypro for 1 week, taking 0.25 - 0.5mg each night (1mg on day one had left me thick-headed the day after). Although I slept through until the alarm on each occasion I did not feel more refreshed than usual for it. My body temp. went down slightly when taking it, then came up again when I stopped, so I'm discontinuing for now.
Peata said:post 100946 Could the cypro have just uncovered where your too-high cortisol had been trying to compensate for hypothyroidism?
khan said:Medicine which I have tried so far are lisuride, cyproheptadine, mirtazapine. Cyproheptadine suits me very well, haven't got any sedation on 4 mg. Cypro clearly reduces my ocd symptoms and depression. Next I would like to try is amitryptaline. Which is better option between cypro and amitryptaline in terms of safety?
docall18 said:post 100948Peata said:post 100946 Could the cypro have just uncovered where your too-high cortisol had been trying to compensate for hypothyroidism?
Yes it could be something along that line. However i take 3 grains of NDT and my TSH is very low and my free t3 is near top of the range. I previously had increased my thyroid up to 5 grains but felt hyper.
I might continue with the cypro for a few more days. I do feel a lot calmer and more balanced on it, just cold and low energy. It could well have just uncovered high adrenaline keeping my metabolism high.
Strangely it has also reduced my apatite.
khan said:post 101044 Medicine which I have tried so far are lisuride, cyproheptadine, mirtazapine. Cyproheptadine suits me very well, haven't got any sedation on 4 mg. Cypro clearly reduces my ocd symptoms and depression. Next I would like to try is amitryptaline. Which is better option between cypro and amitryptaline in terms of safety?
I get noticable effects from 1/2mg (1/8 of 4mg tablet).Peata said:post 101052 Might try a little less cypro. Some recommend 1/2 - 1 mg. per day.
Peata said:post 101052 Might try a little less cypro. Some recommend 1/2 - 1 mg. per day.
Dean said:post 102169 Just as a follow up to my experience before. I tried 1 mg before bed the other night and the next day fell into a deep despair within a few hours of waking that lasted for several hours. Perhaps I was flooded with serotonin after the dosage wore off?
I tried it again because on hindsight I felt that my taking of cypro had helped me with motivation(via lessening learned helplessness, I presume) for even a few weeks after I stopped (due to how much it depressed me.) Thought maybe I could get that benefit without the depressiveness with the small dose at night. So much for that.
It's great to hear that cypro helps some people, but I guess it's important to keep in mind there is some risk involved and the negative side effects, for some, can be dangerous. Hurtling into the mood abyss, but with increased motivation...for example.
Perhaps I will come around to trying cypro again in combo with lisuride at some point, but for now it's on to trying other things.