Makrosky
Member
- Joined
- Oct 5, 2014
- Messages
- 3,982
Hey guys,
I unexpectedly came across a paper on pubmed that included a table comprehensively describing cyproheptadine receptor affinities. I'm not sure if they created the binding profile ex-professo for the paper or they took an already existent one, they say this but I don't understand what that means exactly:
Since they are radioactive binding assays it's in vitro.
(link to the study : http://www.sciencedirect.com/science/ar ... 5705003126)
And here is the table:
I don't understand either why there's a column called "Cyproheptadine" and another one called "HCL". Does that mean cypro can be in another chemical form that is not HCL ?
Interesting to see the effects on adrenergic and beta-two adrenergic receptors....
Is this good info ? Comments welcome!
Also I found this : http://pdsp.med.unc.edu/pdsp.php where you can search for specific affinities for the receptors you want.
I unexpectedly came across a paper on pubmed that included a table comprehensively describing cyproheptadine receptor affinities. I'm not sure if they created the binding profile ex-professo for the paper or they took an already existent one, they say this but I don't understand what that means exactly:
Cyproheptadine HCl and pizotyline maleate and were
examined in a number of different radioligand binding assays
by the NIMH Psychoactive Drug Screening Program; PMMA
was examined at 5-HT2A and 5-HT2C serotonin receptors. The
agents were initially screened several times at a concentration
of 10,000 nM; if an agent produced > 50% inhibition, a Ki
value was determined in quadruplicate. Where an agent
produced < 50% inhibition of binding, a Ki of > 10,000 nM
is reported. Assay details and standard binding protocols can be
found at:http://pdsp.cwru.edu/pdspw/binding.php.
Since they are radioactive binding assays it's in vitro.
(link to the study : http://www.sciencedirect.com/science/ar ... 5705003126)
And here is the table:
I don't understand either why there's a column called "Cyproheptadine" and another one called "HCL". Does that mean cypro can be in another chemical form that is not HCL ?
Interesting to see the effects on adrenergic and beta-two adrenergic receptors....
Is this good info ? Comments welcome!
Also I found this : http://pdsp.med.unc.edu/pdsp.php where you can search for specific affinities for the receptors you want.