Does anyone have any experience on insight with using dopamine agonists for depression and anhedonia such as cabergoline (Dostinex) or pramipexole (Mirapex)? Here's a good guide showing the efficacy of Pramipexole for TRD/anhedonia (also see the video by Dr. Fawcett).
How would cabergoline (Dostinex) compare to pramipexole (Mirapex) for TRD and anhedonia? They're both potent dopamine agonists. Caber is touted to be the most efficacious dopamine agonist therapeutically with the least side effects (most people online prefer it over prami but they use it for body composition and sexual enhancement purposes and I think).
Caber is a potent D2 agonist and weak D1 agonist.
Prami is a moderate D2, D3 and D4 agonist but with stronger D3 agonism. I was under the impression that D2 agonism is the most important site receptor for mood and motivation related disorders while D4 is more responsible for executive functioning (ADHD). Not sure how D3 and D1 agonism comes into play.
Also, is it worth trying caber or prami if one tried l-dopa in the past (180 mg l-dopa daily for a month from mucuna pruriens)? I couldn't sleep on it and I got DAWS symptoms upon discontinuation.
How would cabergoline (Dostinex) compare to pramipexole (Mirapex) for TRD and anhedonia? They're both potent dopamine agonists. Caber is touted to be the most efficacious dopamine agonist therapeutically with the least side effects (most people online prefer it over prami but they use it for body composition and sexual enhancement purposes and I think).
Caber is a potent D2 agonist and weak D1 agonist.
Prami is a moderate D2, D3 and D4 agonist but with stronger D3 agonism. I was under the impression that D2 agonism is the most important site receptor for mood and motivation related disorders while D4 is more responsible for executive functioning (ADHD). Not sure how D3 and D1 agonism comes into play.
Also, is it worth trying caber or prami if one tried l-dopa in the past (180 mg l-dopa daily for a month from mucuna pruriens)? I couldn't sleep on it and I got DAWS symptoms upon discontinuation.