Travis
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- Jul 14, 2016
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Elimination of estrogen by the bilary route is also given in this study [fig 1] and corresponds to about 55 pg/mg(protein(f)) for men. The units they use are ridiculous, and there is considerable ambiguity involved. I am using the information here to convert to a more reasonable number.
The average nitrogen elimination in this study was 31.5 to 26.3 mg(N)/(kg)(body weight)day on an average protein diet: And the obligatory(f) nitrogen loss was 9mg(N)/kg(body weight)day in this study. I think 30mg(N(f))/(kg)(body weight)day is a good average number. To convert total Nitrogen to protein, the Jones Factor is usually conjured-up. The number 6.25 is generally used, but the article Converting nitrogen into protein--beyond 6.25 and Jones' factors, the authors think 5.6 is a more accurate number. I'll use the updated number to convert Nitrogen into protein:
30mg(N(f))/(kg)(body weight)day
Jones factor: 5.6 protein/N
168mg(protein(f))/(kg)(body weight)day
And now we have the right units to multiply with the estrogen concentration of 55 pg/mg(protein(f)):
55 pg/mg(protein(f)) x 168mg(protein(f))/(kg)(body weight)day
55 pg x 168/(kg)(body weight)day [units cancel]
9240pg/(kg body weight)day
9.24ng/(kg body weight)day [I weigh 70 kilos]
647ng/day
Which is on the order of nanograms. I should check other studies to see if this makes sense. There was a really good study done on wild baboons here. They measured an Estrone + Estradiol concentration of ~ 70ng/g(f) [Table 1]. This is expressed as dry matter, so we have to consult this article again [Table 3]. The mean value between the two human groups is 33g(f)/day, but Papio cynocephalus only weighs about one-third of a human, so we can divide by 3 to get 11g(f)/day. This would put the baboon excretion per day at 700ng/day. This is in close agreement to the 647ng/day calculated above.
So, unless I made some terrible math blunder, it looks like the total estrogen excretion per day by the bilary route is only in the nanogram range. This is negligible compared to urinary excretion, which is on the order of micrograms.
The daily production rate of estrogen should match the daily exretion rate: between ~16.8μg/day and ~36μg/day for males. Females can be much higher.
The average nitrogen elimination in this study was 31.5 to 26.3 mg(N)/(kg)(body weight)day on an average protein diet: And the obligatory(f) nitrogen loss was 9mg(N)/kg(body weight)day in this study. I think 30mg(N(f))/(kg)(body weight)day is a good average number. To convert total Nitrogen to protein, the Jones Factor is usually conjured-up. The number 6.25 is generally used, but the article Converting nitrogen into protein--beyond 6.25 and Jones' factors, the authors think 5.6 is a more accurate number. I'll use the updated number to convert Nitrogen into protein:
30mg(N(f))/(kg)(body weight)day
Jones factor: 5.6 protein/N
168mg(protein(f))/(kg)(body weight)day
And now we have the right units to multiply with the estrogen concentration of 55 pg/mg(protein(f)):
55 pg/mg(protein(f)) x 168mg(protein(f))/(kg)(body weight)day
55 pg x 168/(kg)(body weight)day [units cancel]
9240pg/(kg body weight)day
9.24ng/(kg body weight)day [I weigh 70 kilos]
647ng/day
Which is on the order of nanograms. I should check other studies to see if this makes sense. There was a really good study done on wild baboons here. They measured an Estrone + Estradiol concentration of ~ 70ng/g(f) [Table 1]. This is expressed as dry matter, so we have to consult this article again [Table 3]. The mean value between the two human groups is 33g(f)/day, but Papio cynocephalus only weighs about one-third of a human, so we can divide by 3 to get 11g(f)/day. This would put the baboon excretion per day at 700ng/day. This is in close agreement to the 647ng/day calculated above.
So, unless I made some terrible math blunder, it looks like the total estrogen excretion per day by the bilary route is only in the nanogram range. This is negligible compared to urinary excretion, which is on the order of micrograms.
The daily production rate of estrogen should match the daily exretion rate: between ~16.8μg/day and ~36μg/day for males. Females can be much higher.