Hi there!
I apologize in advance for my English (I am Swiss, speaking German...)
Could anyone explain me in simple words why SSRI helps people with anxiety or depression, even if it increases serotonine (or does it not?)?
I have read Ray Peats article about the serotonine and the SSRI. He says himself than SSRI can help but maybe not because it is increasing serotonine but because of inscreasing dopamine or other neurotransmitters. Sounds logical.
But what happens with the increased serotonine in the synaptic gap when taking an SSRI? Ok, when this increases something else like dopamine it would have a good effect on anxiety or depression. But still there is more serotonine in the synaptic gap that would, on the other hand, make the situation worse.
I also wonder why MDMA is able to make people happy. It is also related to increasing the serotonine in the synaptic gap (as SSRI do). But after taking it people feel often depressed. My thoughts on it: Maybe the good effect on MDMA is also dopamine related and not serotonine related. But because serotonine is high after the "trip" ones feels depressed. What's not logical there is that dopamine itself does not make ones feeling happy and loving. Dopamine makes fit, concentrated and (as cocaine does) in higher doses almost maniac. Taking MDMA then would not explain why people feel so happy just because of dopamine.
Well, I do not take drugs. But the effects of drugs like LSD or MDMA are interesting in terms of studying the neurotransmitters.
In my case the SSRI is working. I tried to get rid of it. In very small steps I reduced the dose. Reducing it to 2-3 miligrams worked just fine. But when reducing it to zero my heavy mood swings came back like the time before taking any SSRI. So I had to take again SSRI (as long as I did not find another helper). Only 3 miligrams helped me within 3 days to feel 50% better. But why if serotonine does not help?
I do not get it to be honest... can anyone explain?
I apologize in advance for my English (I am Swiss, speaking German...)
Could anyone explain me in simple words why SSRI helps people with anxiety or depression, even if it increases serotonine (or does it not?)?
I have read Ray Peats article about the serotonine and the SSRI. He says himself than SSRI can help but maybe not because it is increasing serotonine but because of inscreasing dopamine or other neurotransmitters. Sounds logical.
But what happens with the increased serotonine in the synaptic gap when taking an SSRI? Ok, when this increases something else like dopamine it would have a good effect on anxiety or depression. But still there is more serotonine in the synaptic gap that would, on the other hand, make the situation worse.
I also wonder why MDMA is able to make people happy. It is also related to increasing the serotonine in the synaptic gap (as SSRI do). But after taking it people feel often depressed. My thoughts on it: Maybe the good effect on MDMA is also dopamine related and not serotonine related. But because serotonine is high after the "trip" ones feels depressed. What's not logical there is that dopamine itself does not make ones feeling happy and loving. Dopamine makes fit, concentrated and (as cocaine does) in higher doses almost maniac. Taking MDMA then would not explain why people feel so happy just because of dopamine.
Well, I do not take drugs. But the effects of drugs like LSD or MDMA are interesting in terms of studying the neurotransmitters.
In my case the SSRI is working. I tried to get rid of it. In very small steps I reduced the dose. Reducing it to 2-3 miligrams worked just fine. But when reducing it to zero my heavy mood swings came back like the time before taking any SSRI. So I had to take again SSRI (as long as I did not find another helper). Only 3 miligrams helped me within 3 days to feel 50% better. But why if serotonine does not help?
I do not get it to be honest... can anyone explain?