unexamined_whimsy said:It should work in theory but I have tried absurd doses to no avail. Progesterone can down regulate your 5a reductase that takes a few weeks to recover. Experience with aromatase inhibitors in general usually shows that they elevate progesterone.
The surest way to reverse the palpable effects of estrogen in men is to use DHT, but I think it requires some sophistication on account of the user for androgens are suppressive and there is the problem of transfer risk to women and children.
I don't know of any supplements besides creatine that elevate DHT, and DHT itself is illegal in the US. Creatine elevates DHT very much, but many people say it reduces their sex drive. Do you have any idea of the mechanism behind it? DHT itself increases sex drive.
By the way, I read that zinc, copper, and vitamin B6 are all aromatase and prolactin inhibitors, but also inhibit 5-aR. I don't see what's wrong with minimizing 5-aR along with aromatase if progesterone is supplemented, since progesterone is a highly protective hormone, and supports a healthy metabolism by inhibiting lipolysis for example. I bet those vitamins/minerals also increase progesterone. Zinc and copper, and probably progesterone, also increase testosterone by reducing testosterone derivatives, which has positive effects.
Some posts about DHT:
viewtopic.php?f=3&t=2916&p=38306&hilit=creatine#p37649
When I took only T4, I was greatly dysfunctional. But then when I got only 10 mcg of T3 per day, everything improved. I similarly take 90 mcg of T3 per day, and I don't feel hyperthyroid. It's probably getting deactivated like you said. RP said a "slightly hyperthyroid" state can be pleasurable, but I don't understand how a person like me can reach that state.
So I guess it's at best it would be a waste of money on cynomel if it gets converted to reverse-T3, and at worse your theory would be correct about reverse-T3 impairing T3 from functioning as it should.