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Low Toxin Diet Grant Genereux's Theory Of Vitamin A Toxicity
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mattmm24
Member
Yea dairy isn't good now a days. For me personally to get calcium in my diet, which is much needed now a days, I take Calcium Oratate. It's the best absorbed calcium you can get basically.
how much are you usually taking?
Is alcohol as toxic as retinol. It seems they go down similar pathways.
If so then why can a person consume multiple grams of alcohol and recover from it yet the body has trouble processing a couple hundred micro-grams of retinol?
what is the explanation.
- is it because the retinol is fat soluble?
- is it because the alcohol gets utilised as energy?
I assume these are the answers. The question is that if the body were so desperate to get rid of VA then why doesn't it just do so when there are clearly enough ADH and ALDH enzymes to metabolise it in an instant (which is what Smith focusses so heavily on)...
If so then why can a person consume multiple grams of alcohol and recover from it yet the body has trouble processing a couple hundred micro-grams of retinol?
what is the explanation.
- is it because the retinol is fat soluble?
- is it because the alcohol gets utilised as energy?
I assume these are the answers. The question is that if the body were so desperate to get rid of VA then why doesn't it just do so when there are clearly enough ADH and ALDH enzymes to metabolise it in an instant (which is what Smith focusses so heavily on)...
mattmm24
Member
Not much right now. Literally 90 mg and 45 mg of magnesium oratate. It’s extremely strong. Typically other calcium supplements make me feel like crap. But this type is absorbed into the cell. I have had so much energy lately it’s incredible. It’s almost overwhelming in a good way. Peat is definitely correct about calcium. Plus without getting good quality calcium you absorb a ton of heavy metals. Cadmium, lead, arsenic, etc.
youngsinatra
Member
Retinoic acid needed for ceruloplasmin to help deal with copper?
Given its seemingly toxic effects and Grant showing no ill effects, what are they not seeing/misinterpreting?
Induction of ceruloplasmin synthesis by retinoic acid in rats: influence of dietary copper and vitamin A status - PubMed
Ceruloplasmin, a copper-containing acute phase plasma protein, has been shown to be regulated by 13-cis retinoic acid in rats. Ceruloplasmin activity was significantly increased within 24 h and remained elevated for at least 72 h after a single injection of 13-cis retinoic acid. With daily...pubmed.ncbi.nlm.nih.gov
Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes
Abstract. Wilson’s disease (WD) is a copper metabolic disorder caused by a defective ATP7B function. Conventional therapies cause severe side effects and s
academic.oup.com
The body needs plenty of FAD/NAD for retinal (and aldehyde) dehydrogenases to turn retinol into active retinoic acid.
Retinal dehydrogenase can be inhibited by ethanol and antihistamines if I remember correctly. Low NAD levels likely too.
I take a bunch of antihistamines every day. This could be preventing me detoxing vitamin A ?Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes
Abstract. Wilson’s disease (WD) is a copper metabolic disorder caused by a defective ATP7B function. Conventional therapies cause severe side effects and s
The body needs plenty of FAD/NAD for retinal (and aldehyde) dehydrogenases to turn retinol into active retinoic acid.
Retinal dehydrogenase can be inhibited by ethanol and antihistamines if I remember correctly. Low NAD levels likely too.
youngsinatra
Member
Interesting regarding niacin and vitamin A.
The NAD deficient mice got shrunken testicles and got infertile. They accumulated testicular retinol because the rate-limiting step for retinoic acid synthesis, retinal dehydrogenase (NAD dependent) has been shut down.
youngsinatra
Member
Ethanol uses up NAD+ for metabolizing it.
NAD+ depletion causes liver damage.
pubmed.ncbi.nlm.nih.gov
Retinol also uses up NAD+ for metabolizing it.
NAD depletion causes liver damage too?
Maybe someone with vitamin A toxicity (because of long-term high intake) and an alcoholic have a similar physiology?
NAD+ depletion causes liver damage.
Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels required for sirtuin's deacetylase activity - PubMed
NAD(+) levels are markedly reduced when blood alcohol levels are high during binge drinking. This causes liver injury to occur because the enzymes that require NAD(+) as a cofactor such as the sirtuin de-acetylases cannot de-acetylate acetylated proteins such as acetylated histones. This...
pubmed.ncbi.nlm.nih.gov
Retinol also uses up NAD+ for metabolizing it.
NAD depletion causes liver damage too?
Maybe someone with vitamin A toxicity (because of long-term high intake) and an alcoholic have a similar physiology?
Apple
Member
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- Apr 15, 2015
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Apple
Member
- Joined
- Apr 15, 2015
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- 1,267
Do they darken the eyes too? Supposedly darker eye colors are much more at risk for cataracts
Ethanol uses up NAD+ for metabolizing it.
NAD+ depletion causes liver damage.
Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels required for sirtuin's deacetylase activity - PubMed
NAD(+) levels are markedly reduced when blood alcohol levels are high during binge drinking. This causes liver injury to occur because the enzymes that require NAD(+) as a cofactor such as the sirtuin de-acetylases cannot de-acetylate acetylated proteins such as acetylated histones. This...
Retinol also uses up NAD+ for metabolizing it.
NAD depletion causes liver damage too?
Maybe someone with vitamin A toxicity (because of long-term high intake) and an alcoholic have a similar physiology?
How can we boost NAD+ other than supplementing niacinamide? I don’t know about other forms like niacin, nicotinamide riboside, but using 500mg niacinamide daily from a very high end brand (thorne) you eventually run into issues it causes hair loss, water retention and pimples. I dont think its related to methyl depletion alone. Its just a super high dose that im thinking eventually causes issues.
youngsinatra
Member
Not worth a new thread but I've still been clearing stuff out of my nose since posting about an ongoing cold type illness. Just posting for interest really.
I read/heard somewhere, I think from Garrett Smith but not sure that VA is what gives snot its colour.
Today I was at a customers house and I bent down to get something and three or four liquid drops came out of my nose that were the most vivid orange hue I've ever seen come out of a body. Whatever you're imagining right now, it was more than that. It looked like dye.
It could be a sinus infection however I have no pain at all. Just a 'productive' nose. Which, every other time is just normal, clear-ish, maybe a hint of the usual colours.
Mercifully, the awful brain fog with strange vertigo type feeling seems to have faded.
I read/heard somewhere, I think from Garrett Smith but not sure that VA is what gives snot its colour.
Today I was at a customers house and I bent down to get something and three or four liquid drops came out of my nose that were the most vivid orange hue I've ever seen come out of a body. Whatever you're imagining right now, it was more than that. It looked like dye.
It could be a sinus infection however I have no pain at all. Just a 'productive' nose. Which, every other time is just normal, clear-ish, maybe a hint of the usual colours.
Mercifully, the awful brain fog with strange vertigo type feeling seems to have faded.
Milk can have up to 1mg of retinol per liter:
Found this in "Advanced Dairy Chemistry, Volume 3: Lactose, Water, Salts and Minor Constituents", fourth edition:
"The retinol, carotene, and total vitamin A content (as retinol equivalents) for bovine and human milk from the British National Food Composition Dataset is shown in Table 10.1. The mean content of vitamin A and β-carotene in cow’s milk is 40 μg/100 g (range 10–100) and 20 μg (range 3–50), respectively.
Dairy Chemistry And Physics : Jenness,robert : Free Download, Borrow, and Streaming : Internet Archive
Book Source: Digital Library of India Item 2015.139874dc.contributor.author: Jenness,robertdc.date.accessioned: 2015-07-04T03:01:23Zdc.date.available:...
archive.org
Found this in "Advanced Dairy Chemistry, Volume 3: Lactose, Water, Salts and Minor Constituents", fourth edition:
"The retinol, carotene, and total vitamin A content (as retinol equivalents) for bovine and human milk from the British National Food Composition Dataset is shown in Table 10.1. The mean content of vitamin A and β-carotene in cow’s milk is 40 μg/100 g (range 10–100) and 20 μg (range 3–50), respectively.
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