Head Injury

[Peatness]

Some useful info on traumatic head injuries - treatment timing makes a difference

Oxidative Stress: Major Threat in Traumatic Brain Injury - PubMed

In the present review we provide extensive overview of the role of reactive oxygen species (ROS)-induced oxidative stress and its fatal effects on brain after TBI.

pubmed.ncbi.nlm.nih.gov

Traumatic brain injury results in mast cell increase and changes in regulation of central histamine receptors - PubMed

Experimental fluid-percussion models produce brain injury by rapidly injecting saline into the closed cranium of rats. In this study our purpose was to determine how the central histaminergic system, which controls excitability and neurotransmitter release through G-protein coupled receptors, is...

pubmed.ncbi.nlm.nih.gov

Magnesium - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

Early selenium treatment for traumatic brain injury: Does it improve survival and functional outcome? - PubMed

Intravenous Selenase^® treatment demonstrates a significant improvement in functional neurologic outcome. This effect is sustained at six months following discharge.

pubmed.ncbi.nlm.nih.gov

Prevalence and correlates of vitamin D deficiency in adults after traumatic brain injury

The Effect of Vitamin D Supplementation in Patients with Acute Traumatic Brain Injury - PubMed

The Role of Neurotropic B Vitamins in Nerve Regeneration

Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways. Firstly, they constantly ...

www.ncbi.nlm.nih.gov

Rapidly Deteriorating Health With Thiamine Deficiency - Hormones Matter

Thiamine deficiency is a well-documented condition and has been known for hundreds of years, yet the medical community doesn't consider it.

www.hormonesmatter.com

Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex

Based on the fact that traumatic brain injury is associated with mitochondrial dysfunction we aimed at localization of mitochondrial defect and attemp…

www.sciencedirect.com

Niacinamide And Progesterone For Traumatic Brain Injury

Traumatic Brain Injury (tbi)

Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency - PubMed

Experimental thiamine deficiency (TD) is a classical model of metabolic encephalopathy and selective cell loss in the brain resulting from a generalized, low-grade oxidative deficit. Late stages of TD are characterized by hemorrhages in the brain indicating a disruption of the blood-brain...

pubmed.ncbi.nlm.nih.gov

Traumatic Brain Injury and Oxygen: Understanding the Role of Free Radicals - Hormones Matter

Traumatic brain injury is a significant cause of death and disability. Free oxygen radicals are implicated as major contributors to the secondary injury.

www.hormonesmatter.com

Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit

Today, trauma is known to be the third leading cause of death in most countries. Studies have demonstrated below-normal plasma levels of antioxidants in trauma patients. The present study aimed to assess the efficacy of Coenzyme Q10 (CoQ10) on oxidative ...

www.ncbi.nlm.nih.gov

 

[Peatness]

Taurine and Brain injury

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury - PubMed

The protective effect of taurine against inflammation, apoptosis and oxidative stress in traumatic brain injury was investigated in the present study. Taurine is a non‑proteogenic and essential amino acid in animals. It plays a critical nutritional role in brain cell growth, differentiation, and...

pubmed.ncbi.nlm.nih.gov

Taurine Protects against Postischemic Brain Injury via the Antioxidant Activity of Taurine Chloramine

Taurine is ubiquitously distributed in mammalian tissues and is highly concentrated in the heart, brain, and leukocytes. Taurine exerts neuroprotective effects in various central nervous system diseases and can suppress infarct formation in stroke. Taurine ...

www.ncbi.nlm.nih.gov

https://tahomaclinic.com/Private/Articles2/Taurine/Wang%202016%20-%20Protective%20effects%20of%20taurine%20in%20traumatic%20brain%20injury.pdf

 

[Peatness]

[Recovering from traumatic brain injury (concussions)] Pregnenolone and progesterone are the most important things for the after-effects of concussions. Pregnenolone, if it’s pure, doesn’t have any side effects, so it’s safe in large doses. 100 mg per day is usually an effective amount (I took 3000 to 4000 mg per day for a year, with no side effects). Progesterone is usually helpful in moderate, physiological amounts, maybe 20 to 30 mg per day (with food), but more would be o.k. if the effects seem better. The frontal lobes of the brain are involved in focussing attention and planning, and these hormones stabilize the major frontal lobe nerves. Vitamin D and calcium are essential for the protective effects of these hormones, so it would be good to have a vitamin D blood test. Many people, when they don’t get much direct sunlight exposure, need about 5000 i.u. of vitamin D3 per day to keep the blood level around the normal 50 ng/ml. Dr. Peat

 

[Peatness]

Concussion Treatment

Happy New Year All... unfortunately my wife slipped with socks on a slippery staircase and fell about 15 steps and was unconscious for about 3 minutes. Since then she has had problems with verbal fluency due to this concussion. I search on Ray Peat Forum but no discussion of concussion...

raypeatforum.com

 

[BRMarshall]

Thanks for this compilation....i am looking for ways to address chronic head injuries to which i would rather find relief in substances other than pot. I do use progesterone, and pregnenalone inconsistently. I believe that marijuana does increase pregnenalone (?) Often i have quit pot to then return to use relative to head injuries...

 

[Peatness]

The Impact of Riboflavin on Sports-related Concussion​

ClinicalTrials.gov

clinicaltrials.gov

ClinicalTrials.gov

www.clinicaltrials.gov

Cytoflavin ((Inosine + Nicotinamide + Riboflavin + Succinic Acid)

Administration of riboflavin improves behavioral outcome and reduces edema formation and glial fibrillary acidic protein expression after traumatic brain injury - PubMed

Previous studies have shown that administration of riboflavin, vitamin B2, significantly reduced edema formation following experimental stroke. The present study evaluated the ability of B2 to improve behavioral function, reduce edema formation, and limit glial fibrillary acidic protein (GFAP)...

pubmed.ncbi.nlm.nih.gov

Riboflavin Has Neuroprotective Potential: Focus on Parkinson’s Disease and Migraine

With the huge negative impact of neurological disorders on patient’s life and society resources, the discovery of neuroprotective agents is critical and cost-effective. Neuroprotective agents can prevent and/or modify the course of neurological ...

www.ncbi.nlm.nih.gov

 

[Peatness]

Sports Concussion and the Clinical Neurologist, Part I - Practical Neurology

Neurologists, who increasingly will confront patients diagnosed with sports concussion, must be adept at identifying and managing the condition. Part I of a series reviews epidemiology, definition, mechanism, and clinical manifestations.

practicalneurology.com

Sports Concussion and the Clinical Neurologist, Part II - Practical Neurology

Neurologists, who increasingly will confront patients diagnosed with sports concussion, must be adept at identifying and managing the condition. Part II of a series reviews screening modalities

practicalneurology.com

Sports Concussion and the Clinical Neurologist, Part III - Practical Neurology

The third and final installment in a series on sports concussion explores treatment and the role of the neurologist.

practicalneurology.com

 

[Peatness]

Thanks for this compilation....i am looking for ways to address chronic head injuries to which i would rather find relief in substances other than pot. I do use progesterone, and pregnenalone inconsistently. I believe that marijuana does increase pregnenalone (?) Often i have quit pot to then return to use relative to head injuries...

I'm afraid I don't know much about marijuana other than the smell makes me feel ill. I'm experimenting with higher doses of riboflavin (b2)

Riboflavin for Strange Unresolved Health Problems | Chris Masterjohn​

View: https://www.youtube.com/watch?v=q0LCH4RMW-s

 

[Peatness]

Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury

In this study, using two different injury models in two different species, we found that early post-injury treatment with N-Acetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protocol ...

www.ncbi.nlm.nih.gov

Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats - PubMed

Efficacy of N-acetylcysteine (NAC) in traumatic brain injury (TBI)-induced mitochondrial dysfunction was evaluated following controlled cortical impact injury in rats. Respiratory function and calcium transport of rat forebrain mitochondria from injured and uninjured hemispheres were examined...

pubmed.ncbi.nlm.nih.gov

 

[Peatness]

Frontiers | Consolidated Biochemical Profile of Subacute Stage Traumatic Brain Injury in Early Development

Traumatic brain injury (TBI) in general has varied neuropathological consequences depending upon the intensity and biomechanics of the injury. Furthermore, i...

www.frontiersin.org

Posttraumatic Cranial Cystic Fibrous Dysplasia

A 14-year-old was girl admitted to our hospital with a subcutaneous mass of the occipital head. The mass had grown for 6 years, after she had sustained a head injury at the age of 6, and was located directly under a previous wound. Skull X-ray Photograph ...

www.ncbi.nlm.nih.gov

 

[Peatness]

Neurotoxicity Associated with Traumatic Brain Injury, Blast, Chemical, Heavy Metal and Quinoline Drug Exposure - PubMed

Chronic, excessive exposure, and accumulation of neurotoxic agents such as heavy metals (lead, mercury, cadmium), mefloquine (Lariam), and food additives such as monosodium glutamate and aspartame cause neurotoxicity and brain damage. This chemical-induced brain damage closely resembles the...

pubmed.ncbi.nlm.nih.gov

To address this current deficit in military health care, it is recommended that efficacious, nontoxic, neuroprotective, and neuroregenerative agents such as highly bioavailable magnesium, nutritional lithium, zinc, selenium, boron, ascorbate, tocopherols, heavy metal chelators, and glutathione precursors such as N-acetyl-cysteine be immediately used as a "protective shield" and to support critical healing processes in the brain and nervous system.

 

[Peatness]

Dr. Mark Gordon: Hormones to Heal Traumatic Brain Injuries - Life Extension

Dr. Mark Gordon explains how his work with wounded soldiers led to identifying hormone deficiencies (cortisol, DHEA, testosterone) as a cause for traumatic brain injuries . How the hormone therapy can heal brain injuries.

www.lifeextension.com

Dr. Mark Gordon: Hormone Therapy For Traumatic Brain Injury - Life Extension

Dr. Mark Gordon anti inflammatory protocol has successfully treated people with traumatic brain injury by restoring hormone levels of hormones such as testosterone, cortisol, TSH, DHEA, estrogens.

www.lifeextension.com

Mark L. Gordon, MD leading the battle against symptomatic TB

The Millennium Health Centers, Inc. since 2004 has been perfecting the assessment and treatment of both Military and Civilian populations with symptomatic traumatic and non-traumatic brain injuries.

www.tbimedlegal.com

 

[Peatness]

Energy and Protein Needs During Early Feeding Following Traumatic Brain Injury - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

Summary of Recommendations - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

 

[Peatness]

The New Revolution in Hacking Traumatic Brain Injury and PTSD - #431

Could you be walking around with a traumatic brain injury, or TBI, and not even know it? Could it be causing depression, or changes in your personality that you can’t explain? Dr. Mark Gordon, interventional endocrinology specialist and Medical Director at the Millennium Warrior Angels...

daveasprey.com

The New Revolution in Hacking Traumatic Brain Injury and PTSD - Dr. Mark Gordon & Andrew Marr​

View: https://www.youtube.com/watch?v=0NVae6_90HY&t=155s


Be mindful this is from 2017 way before we knew what darpa were up to. Plus Dr Gordon thinks fish oils are good so be mindful that this is not peaty. I used a lot of fish oil supplements in the past and will never touch them again. The good news is that he suggests that the brain needs sugar and should not be deprived of it when in an injury state.

This is the mold documentary

Moldy (Full Documentary) feat. Dave Asprey​

View: https://www.youtube.com/watch?v=VI0_azQv6N8

 

[Peatness]

Choline May Help Improve Cognitive Function Following Brain Injury – Neurologic Rehabilitation Institute

Choline - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

CDP-Choline and Working Memory After TBI: A Neuroimaging Study - Full Text View - ClinicalTrials.gov

CDP-Choline and Working Memory After TBI: A Neuroimaging Study - Full Text View.

clinicaltrials.gov

 

[Peatness]

Mitochondria Dysfunction and Inflammation in Traumatic Brain Injury: Androgens to the Battlefront

https://ulir.ul.ie/bitstream/handle/10344/10886/McGovern_2021_Mitochondria.pdf?sequence=2

Deficiency in Androgen Receptor Aggravates Traumatic Brain Injury-Induced Pathophysiology and Motor Deficits in Mice - PubMed

Androgens have been shown to have a beneficial effect on brain injury and lower reactive astrocyte expression after TBI. Androgen receptors (ARs) are known to mediate the neuroprotective effects of androgens. However, whether ARs play a crucial role in TBI remains unknown. In this study, we...

pubmed.ncbi.nlm.nih.gov

 

[Peatness]

Energy expenditure and protein requirements after traumatic injury

Energy expenditure and protein requirements after traumatic injury - PubMed

Traumatic injury induces hypermetabolism. The degree of hypermetabolism can be variable, depending on the type of injury, the degree of inflammation, body composition, age, and treatment regimens. To estimate metabolic rate in some types of injury, predictive equations have been published. Some...

pubmed.ncbi.nlm.nih.gov

Abstract

Traumatic injury induces hypermetabolism. The degree of hypermetabolism can be variable, depending on the type of injury, the degree of inflammation, body composition, age, and treatment regimens. To estimate metabolic rate in some types of injury, predictive equations have been published. Some of these equations have been tested in validation studies. For other types of injury, equations do not exist. Some expert panels have recommended measuring in lieu of estimating metabolic rate, though studies have not been performed to determine whether clinical outcome is affected by the method used to determine energy requirements. Traumatically injured patients are usually catabolic, but protein needs after traumatic injury continue to be debated. Some suggest that 1.5 g protein per kg body weight is adequate and that any additional protein is simply oxidized, adding to the nitrogen load to be excreted. Alternately, protein intake >2.0 g/kg body weight increases the absolute rate of body protein synthesis, and achievement of nitrogen balance has been associated with survival. Thus, provision of high-protein feeding to achieve nitrogen balance might be worthwhile, even if that balance is achieved at the cost of additional nitrogen production.

 

[David PS]

Wow, you have created quite a resource. Here is another one for your collection.

Creatine - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

 

[Peatness]

Wow, you have created quite a resource. Here is another one for your collection.

Creatine - Nutrition and Traumatic Brain Injury - NCBI Bookshelf

Thank you.

 

[Peatness]

Thanks for finding this @David PS

Serum metabolome associated with severity of acute traumatic brain injury

Serum metabolome associated with severity of acute traumatic brain injury - Nature Communications

Traumatic brain injury is associated with changes to the metabolome. Here the authors show that acute traumatic brain injury has distinctive serum metabolic patterns which may suggest protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

www.nature.com