- Joined
- Apr 5, 2016
- Messages
- 1,668
As some of you who follow my posts might know my mother has Parkinsons disease and the only treatment that has been successful in improving her symptoms has been cyproheptadine.
Recently she decided to start taking high doses of thiamine as there has been some good evidence that it had benefits for PD patients. However there have been a few times now where her symptoms have been made significantly worse. Great increase in anxiety and shaking.
I think this is because the thiamine is essentially reving up her metabolism too fast and body cannot deal with it. Her liver, glycogen and energy metabolism simply cannot cope with the thiamine. So when she takes the high dose thiamine, the body in an attempt to get enough glucose to use the thiamine raises stress hormones even higher (cortisol, serotonin, adrenaline) which makes everything even worse.
I've always told her to take things slow and make sure she has eaten enough before taking the supplements (although I think she is ignoring me/forgets).
Anyone have any thoughts besides my own hypothesis as to what could be causing the worsening of symptoms?
I want to get her some labs using @haidut service but I'm not sure what to get.
Recently she decided to start taking high doses of thiamine as there has been some good evidence that it had benefits for PD patients. However there have been a few times now where her symptoms have been made significantly worse. Great increase in anxiety and shaking.
I think this is because the thiamine is essentially reving up her metabolism too fast and body cannot deal with it. Her liver, glycogen and energy metabolism simply cannot cope with the thiamine. So when she takes the high dose thiamine, the body in an attempt to get enough glucose to use the thiamine raises stress hormones even higher (cortisol, serotonin, adrenaline) which makes everything even worse.
I've always told her to take things slow and make sure she has eaten enough before taking the supplements (although I think she is ignoring me/forgets).
Anyone have any thoughts besides my own hypothesis as to what could be causing the worsening of symptoms?
I want to get her some labs using @haidut service but I'm not sure what to get.