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Delightful characterization. I am also very sensitive to serotonin, probably naturally low levels of MAO-A. But whatever the cause, I exhibit a kind of madness when it happens. Very unpleasant, both for me and for anyone else unlucky enough to be around me at the time :)
I noticed that I am again able to tolerate eating bananas and probably pineapple too because I have addressed my thiamine deficiency problem. Thiamine is used to clear serotonin from the brain. So if you tend to moments of madness, perhaps you might be interested in learning about the thiamine connection? I am well versed in moments of madness myself as I have heavy metal poisoning which uses up thiamine (a chemical bond happens) resulting in unfortunate "miscommunications" so I'm glad I looked into it and now supplement thiamine.
pubmed.ncbi.nlm.nih.gov
www.hormonesmatter.com
Do you think the allithiamine is clearing the serotonin as well as the nasty tasting thiamine hcl? Have you noticed any difference in the serotonin symptoms? I'm taking a horse dose of thiamine hcl (2 grams/day). I'm pretty happy and feel that I've overcome the high serotonin issue. Of course I pretty much stay at home and work in the garden a whole lot.
Very good question but I have no answer. When I was young we had mercury thermometers and I would play with the mercury when they broke, and we probably had lead to play with, and I once had a job handling huge quantities of powdered aluminum. I was white with it from head to toe and all through my nasal passages every day. So metal poisoning might also have something to do with the serotonin syndrome I'm prone to. Until talking to you I'd been unaware that there was such a connection.
It's very insping reading this, thanks.Maybe you're onto something.... My gut got really messed up after three rounds of various antibiotics summer of 2020 (bladder infection). The Bactrim antibiotic blocked my thiamine function; I was already low in it because of the heavy metal poisoning so I really got slammed by the bactrim. I was very sick for months. There are a lot of antibiotics that work by blocking thiamine function to kill the bacteria that need it to survive.
There's this:
and this:
SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? - Hormones Matter
Is it possible that small intestinal bacterial overgrowth (SIBO) is simply a symptom of an underlying vitamin B1 or thiamine deficiency?
Thiamine and the Microbiome - Hormones Matter
Health depends on the 70-100 trillion single-celled organisms that live in our intestines.
I got well, including my gut function, when I high dosed thiamine hcl. For me that meant 1 gram of thiamine hcl 2Xday. I also take magnesium glycinate and I consume a pretty healthy diet that is not high in starch. It's more high in dairy and gelatin and mushrooms. I let the gut bacteria work it out for themselves. I think the high dose thiamine hcl improved the intestine environment and the healthy gut bacteria recolonized where they belong.
I did try the TTFD type of thiamine but I reacted badly to it because my glutathione was low due to the lead poisoning. So I stuck with thiamine hcl.
Please note that a big part of normalizing my gut function had to do with normalizing my stomach acid. Thiamine supplementation fixed my low stomach acid. When I got up to the 2 grams/day of thiamine hcl, suddenly I craved beef steak so I ate them maybe twice/week for several weeks. They were wonderful and I was able to digest the meat for the first time in decades.
I have memories of doing that too!! My grandfather encouraged it. He would demonstrate how to turn a penny into a dime by rubbing it all over with the mercury. My strongest memory of it was of my grandmother wringing her hands and saying that it was dangerous and maybe he shouldn't do that. He snarled her back down into submission. Years later, my grandfather lost what was left of his mind.
Not good. I've got aluminum too. I think it was from eating entire jars of dill pickles daily after school when I was a kid. Drank all the juice too. Aluminum is a very tough one to resolve. The EDTA by IV I think helped a little bit, at least in that the aluminum did show up on the EDTA challenge tests. I've had over 120 EDTA IV treatments (one a week, 3 hour IV) over a period of many years. I took to drinking a daily liter bottle of Fuji water for the aluminum for 3-4 months about a year ago. I do think it helped. You can search for "silica water for aluminum" to learn more about it. Here's one result:
pubmed.ncbi.nlm.nih.gov
I've read a lot about thiamine over the past 2 years. What I learned revealed to me that most all of my health problems are due to thiamine deficiency/functional blockage. I think I was set up for this problem via my load of heavy metals I acquired in childhood. I suspect that the house we lived in back in the 1950's-1960's had issues with lead contamination in the water pipes due to lead solder of the copper pipes. Both of my siblings became mentally ill when they were children; both were diagnosed with paranoid schizophrenia in their early 20's. My parents stayed in that house for the rest of their lives. My mother died of brain cancer and my father died of Alzheimer's.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
www.hormonesmatter.com
Flagyl is the gift that keeps on giving. I think it would be helpful for you to research that. Yes, I think thiamine would help.
www.hormonesmatter.com
Yes, I think it would.
www.hormonesmatter.com
www.hormonesmatter.com
Please read the articles at the links provided in this post responding to both you and to @Nokoni .
Yes, I think you're right. Different doctors using various thiamine supplements have their own specific favorites. Opinions vary as to which one works best. Dr. Costantini favored thiamine hcl by injection for his Parkinson's Disease patients. His website provides conversion info re. how much oral thiamine hcl equals a 100mg injection of thiamine hcl. Dr. Lonsdale, Dr. Marrs, and Elliot Overton are all fans of TTFD thiamine, because it has no absorption issues when taken orally. Forgive my ignorance but I do not know if allithiamine is exactly the same as TTFD.
There's info online about how some bacteria consume thiamine and some bacteria make thiamine. I personally experienced excellent improvement in my gut function when I started taking high dose thiamine hcl. I'm sorry but I don't know the details as to exactly how that worked. I just know that the problems that I had, including swelling of the intestine (I pooped little squiggles for months) resolved when I took high dose thiamine hcl. This happened after two days of taking 1 gram of thiamine hcl 2Xday. I had spent the prior 4 months working up to that dose.
I think that it's possible that a person can get a genetic mutation, a "work around", that helps the body cope and not die from a thiamine deficiency. I think that it would make you more susceptible to serotonin syndrome. I suffered from serotonin syndrome for years. A doctor had prescribed high dose 5-htp which I took for about 10 years. I know what that feels like. I stopped the 5-htp around 2015, started peating, doubled my prescription thyroid desiccated thyroid med. During that time I could not eat high serotonin foods, including: bananas, pineapple, tomatoes, other nightshade plants. After high dosing thiamine hcl, I no longer am sensitive to the high serotonin foods and I don't have any symptoms of serotonin syndrome.
I'm pretty sure you're right. There's a genetic issue that can be passed along to the next generation that makes them require more thiamine than average. I don't know if I inherited that or not; the fact that both of my siblings suffered terribly from diseases known to be caused by thiamine deficiency makes me think it's possible. However we were all exposed to high doses of heavy metals as children so the family's health problems could have originally been environmentally caused. Heavy metals stick around for the duration; lead is known to rip the thiamine molecule apart and bond to the sulfur part of it, which in effect causes a thiamine deficiency even when consuming healthy amounts of it.
Those are the best pineapples I’ve tried. 0 acidic taste. I’ve been eating a bunch lately too lol.
