I know pregnenolone/progesterone work via multiple mechanisms such as inhibiting serotonin, opposing estrogen, lowering FFA, etc. However, this method caught my eye and I thought I'd share it since many people here have trouble converting T4 into T3.
As you all know both pregnenolone and porgesterone both reliably raise levels of allopregnanolone. The Wkipedia page for allopregnanolone has this to say about it (among other things).
https://en.wikipedia.org/wiki/Allopregnanolone
"...Similarly to many other GABAA receptor positive allosteric modulators, allopregnanolone has been found to act as an inhibitor of L-type voltage-gated calcium channels (L-VGCCs),[13] including α1 subtypes Cav1.2 and Cav1.3.[14] However, the threshold concentration of allopregnanolone to inhibit L-VGCCs was determined to be 3 μM (3,000 nM), which is far greater than the concentration of 5 nM that has been estimated to be naturally produced in the human brain.[14] Thus, inhibition of L-VGCCs is unlikely of any actual significance in the effects of endogenous allopregnanolone.[14] Also, allopregnanolone, along with several other neurosteroids, has been found to activate the G protein-coupled bile acid receptor (GPBAR1, or TGR5).[15] However, it is only able to do so at micromolar concentrations, which, similarly to the case of the L-VGCCs, are far greater than the low nanomolar concentrations of allopregnanolone estimated to be present in the brain.[15]"
And activating the bile acid receptor has the following effect:
https://en.wikipedia.org/wiki/Allopregnanolone
"...One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.[3][4]"
So, for the people that have liver issues, or otherwise trouble with Synthroid or regular Cynoplus, instead of adding T3 (or if you don't react well to it) you can take some pregnenolone and this should increase the conversion of T4 into T3 and raise your metabolic rate. Most endocrinologist agree that high doses of pregnenolone/progesterone cause hyperthyroidism, so I guess this is one of the primary mechanisms.
As you all know both pregnenolone and porgesterone both reliably raise levels of allopregnanolone. The Wkipedia page for allopregnanolone has this to say about it (among other things).
https://en.wikipedia.org/wiki/Allopregnanolone
"...Similarly to many other GABAA receptor positive allosteric modulators, allopregnanolone has been found to act as an inhibitor of L-type voltage-gated calcium channels (L-VGCCs),[13] including α1 subtypes Cav1.2 and Cav1.3.[14] However, the threshold concentration of allopregnanolone to inhibit L-VGCCs was determined to be 3 μM (3,000 nM), which is far greater than the concentration of 5 nM that has been estimated to be naturally produced in the human brain.[14] Thus, inhibition of L-VGCCs is unlikely of any actual significance in the effects of endogenous allopregnanolone.[14] Also, allopregnanolone, along with several other neurosteroids, has been found to activate the G protein-coupled bile acid receptor (GPBAR1, or TGR5).[15] However, it is only able to do so at micromolar concentrations, which, similarly to the case of the L-VGCCs, are far greater than the low nanomolar concentrations of allopregnanolone estimated to be present in the brain.[15]"
And activating the bile acid receptor has the following effect:
https://en.wikipedia.org/wiki/Allopregnanolone
"...One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.[3][4]"
So, for the people that have liver issues, or otherwise trouble with Synthroid or regular Cynoplus, instead of adding T3 (or if you don't react well to it) you can take some pregnenolone and this should increase the conversion of T4 into T3 and raise your metabolic rate. Most endocrinologist agree that high doses of pregnenolone/progesterone cause hyperthyroidism, so I guess this is one of the primary mechanisms.