KyleKingsly
Member
- Joined
- Feb 15, 2018
- Messages
- 97
Got a huge bag of Inositol before I knew about Peat and this forum. Now I know to avoid promoting serotonin, which does stuff seems to do by sensitizing serotonin receptors. In addition, some think that it could act like an SSRI, which I don't want anything to do with. 19 Inositol (Myoinositol) Benefits: PCOS, Anxiety, Weight Loss - Selfhacked
However, it does seem to calm me down and make me feel subtly but noticeably more relaxed in social settings. This is probably partially due to its role in increasing GABA, but it also is likely linked to Inositol's role in upregulating D2 receptors, including striatal D2: Chronic inositol increases striatal D(2) receptors but does not modify dexamphetamine-induced motor behavior. Relevance to obsessive-compulsive dis... - PubMed - NCBI.
Dopamine is great as we all know but in particular striatal dopamine receptors are highly linked to social status and acumen. People with social anxiety like me tend to have lower striatal dopamine receptor senstivity, while people with higher striatal receptor are basically better liked (https://www.elsevier.com/about/pres...eceptor-density-correlates-with-social-status).
So if we can boost our striatal receptor sensitivity, it's very likely going to help us be more confident and have better social lives. There are very few substances I've come across that upregulate dopamine receptors, particularly in the striatum, so inositol is very much unique in this MoA afaik.
The second link I attached states that inositol has a significant effect on D2 receptors, but an insignificant one on serotonin receptors, at least in the striatum. That makes me think that Inositol would be worth it overall, particularly for someone like me. However, I've also seen a number of people on here saying not to take Inositol. So just wanted to get some guidance overall on whether it's worth it.
However, it does seem to calm me down and make me feel subtly but noticeably more relaxed in social settings. This is probably partially due to its role in increasing GABA, but it also is likely linked to Inositol's role in upregulating D2 receptors, including striatal D2: Chronic inositol increases striatal D(2) receptors but does not modify dexamphetamine-induced motor behavior. Relevance to obsessive-compulsive dis... - PubMed - NCBI.
Dopamine is great as we all know but in particular striatal dopamine receptors are highly linked to social status and acumen. People with social anxiety like me tend to have lower striatal dopamine receptor senstivity, while people with higher striatal receptor are basically better liked (https://www.elsevier.com/about/pres...eceptor-density-correlates-with-social-status).
So if we can boost our striatal receptor sensitivity, it's very likely going to help us be more confident and have better social lives. There are very few substances I've come across that upregulate dopamine receptors, particularly in the striatum, so inositol is very much unique in this MoA afaik.
The second link I attached states that inositol has a significant effect on D2 receptors, but an insignificant one on serotonin receptors, at least in the striatum. That makes me think that Inositol would be worth it overall, particularly for someone like me. However, I've also seen a number of people on here saying not to take Inositol. So just wanted to get some guidance overall on whether it's worth it.