Zpol
Member
- Joined
- Apr 14, 2013
- Messages
- 929
- Age
- 45
Thanks Mito. Good info.
I have current blood plasma tests indicating elevated homocysteine so I'm going to give the creatine a go.
Makes sense to supplement the methylfolate every other day instead of everyday, to avoid overdosage.
Hydrolized collagen for extra glycine seems good too. I think where I went wrong with this before is not taking with meals (I was putting it in coffee; not a balanced meal or snack).
I highly recommend the Methylate Your Way to Mental Health With Dopamine podcast as well.
It's important to get enough glycine with methionine (the podcast explains why too much methionine in one sitting could disrupt proper methylation).
RP does caution against too much methylation because too many methyl donor groups attached to DNA is an indication of cellular aging (not necessarily chronological aging though). One cause of methyl donor groups attaching to DNA is excess estrogen. Basically anything that damages DNA will require methyl donor groups to repair the damage but these get left behind and sort of forgotten.
Bottom line is that one needs adequate methylation but not too much.
B9 and B12 are risky supp's to take for everyone as studies show a correlation to cancer.
This thread explains the risks (apologies if you've already read it)...
DNA Methylation, Aging, And Cancer
Thanks for the link to that study, I will read it more thoroughly soon!
I have current blood plasma tests indicating elevated homocysteine so I'm going to give the creatine a go.
Makes sense to supplement the methylfolate every other day instead of everyday, to avoid overdosage.
Hydrolized collagen for extra glycine seems good too. I think where I went wrong with this before is not taking with meals (I was putting it in coffee; not a balanced meal or snack).
Someone posted a link to a page about Walsh and how he treats schizophrenia regulating methylation. Many Mentally Ill Have Histamine-methylation Ratio Imbalance
Undermethylators shouldn't take b9 or b12 but methionine. After reading this I took some methionine I had laying around and my face looked noticeably less tired and worn after a few days. I had looked this tired and run down for months and it was affecting my self esteem, methionine fixed it.
I do have low creatinine. Need to listen to that podcast.
Seems to me Peats advice is mainly geared towards overmethylators (?)
I highly recommend the Methylate Your Way to Mental Health With Dopamine podcast as well.
It's important to get enough glycine with methionine (the podcast explains why too much methionine in one sitting could disrupt proper methylation).
RP does caution against too much methylation because too many methyl donor groups attached to DNA is an indication of cellular aging (not necessarily chronological aging though). One cause of methyl donor groups attaching to DNA is excess estrogen. Basically anything that damages DNA will require methyl donor groups to repair the damage but these get left behind and sort of forgotten.
Bottom line is that one needs adequate methylation but not too much.
B9 and B12 are risky supp's to take for everyone as studies show a correlation to cancer.
This thread explains the risks (apologies if you've already read it)...
DNA Methylation, Aging, And Cancer
Thanks for the link to that study, I will read it more thoroughly soon!