raypeatclips
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Mechanism of Hypokalemia in Magnesium Deficiency
"Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency."
This part is interesting, elevated aldosterone is needed with mag deficiency to lower potassium. I wonder if being sodium replete (to lower aldosterone) with magnesium deficiency would prevent the potassium wasting. I would like to see what effect sodium has on holding on to magnesium I have seen Peat say adequate sodium is beneficial for the calcium, potassium, magnesium etc
"It is estimated that more than 50% of clinically significant hypokalemia has concomitant magnesium deficiency. "
"Hypokalemia associated with magnesium deficiency is often refractory to treatment with K+. Co-administration of magnesium is essential for correcting the hypokalemia"
"To support this idea, Baehler et al.5 showed that administration of magnesium decreases urinary K+ excretion and increases serum K+ levels in a patient with Bartter disease with combined hypomagnesemia and hypokalemia. Similarly, magnesium replacement alone (without K+) increases serum K+ levels in individuals who have hypokalemia and hypomagnesemia and receive thiazide treatment.6 Magnesium administration decreased urinary K+ excretion in these individuals."
"Additional factors that would provide an unabating driving force for K+ secretion (i.e., prevent apical membrane hyperpolarization), such as an increase in distal sodium delivery and elevated aldosterone levels, are important for exacerbating K+ wasting in magnesium deficiency (Figure 3)"
I am not quite sure what that sodium reference means, elevated sodium in the presence of elevated aldosterone increases the wasting? Elevated aldosterone alone increases the wasting. I have seen sodium (as well as magnesium) can reduce aldosterone so I think adequate sodium and magnesium is required to lower the aldosterone. Perhaps a lot of the issues in this article can be caused by sodium deficiency as well.
Mechanism of Hypokalemia in Magnesium Deficiency
"Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency."
This part is interesting, elevated aldosterone is needed with mag deficiency to lower potassium. I wonder if being sodium replete (to lower aldosterone) with magnesium deficiency would prevent the potassium wasting. I would like to see what effect sodium has on holding on to magnesium I have seen Peat say adequate sodium is beneficial for the calcium, potassium, magnesium etc
"It is estimated that more than 50% of clinically significant hypokalemia has concomitant magnesium deficiency. "
"Hypokalemia associated with magnesium deficiency is often refractory to treatment with K+. Co-administration of magnesium is essential for correcting the hypokalemia"
"To support this idea, Baehler et al.5 showed that administration of magnesium decreases urinary K+ excretion and increases serum K+ levels in a patient with Bartter disease with combined hypomagnesemia and hypokalemia. Similarly, magnesium replacement alone (without K+) increases serum K+ levels in individuals who have hypokalemia and hypomagnesemia and receive thiazide treatment.6 Magnesium administration decreased urinary K+ excretion in these individuals."
"Additional factors that would provide an unabating driving force for K+ secretion (i.e., prevent apical membrane hyperpolarization), such as an increase in distal sodium delivery and elevated aldosterone levels, are important for exacerbating K+ wasting in magnesium deficiency (Figure 3)"
I am not quite sure what that sodium reference means, elevated sodium in the presence of elevated aldosterone increases the wasting? Elevated aldosterone alone increases the wasting. I have seen sodium (as well as magnesium) can reduce aldosterone so I think adequate sodium and magnesium is required to lower the aldosterone. Perhaps a lot of the issues in this article can be caused by sodium deficiency as well.