Broken man
Member
- Joined
- Sep 11, 2016
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- 1,693
Hello all, I would like to show you new study about methylene blue and cholestasis and to tell you that I knew about methylene blue for about 5 years, I tried it with doses about 1 mg, felt nothing and decided to quit. Its four months that I joined facebook group where I found member that is using about 50 mg daily, I was very curious about how he is feeling and if he is scared about potential side effects, he wrote me that he wrote some articles about methylene blue and that side effects happen only when really high dose is used, also told me that there is no known chemical that can be so beneficial for human as is methylene blue. Cholestasis is very silent but danger disease, it means that you cant detox estrogen properly. I was having problem with low bile acids for years, steroids or TUDCA did not help me like methylene blue did. The dose is also not high, if I am calculating it correctly, it should be 8 mg - 16 mg for 100 kg weighing person. I am using 20 mg to 40 mg every day.
(PDF) Methylene Blue Improves Mitochondrial Function in The Liver of Cholestatic Rats
About the study, Its interesting that its improving cholestasis because I also read study where they found MB increased SIRT1 and cured "fatty" liver but SIRT1 is increased in cholestasis and agents that antagonise this protein improve cholestasis also.....
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis - PubMed
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease - PubMed
but also SIRT1 can help :
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis
@Hans @Zpol
(PDF) Methylene Blue Improves Mitochondrial Function in The Liver of Cholestatic Rats
About the study, Its interesting that its improving cholestasis because I also read study where they found MB increased SIRT1 and cured "fatty" liver but SIRT1 is increased in cholestasis and agents that antagonise this protein improve cholestasis also.....
SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis - PubMed
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease - PubMed
but also SIRT1 can help :
Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid fed mouse model of cholestasis
@Hans @Zpol
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