If nicotine has a similar effect to phenylbutyrate acting as a hdac inhibitor its liable to have higher addictive potential, looking through the threads on nicotine by the op you can see this is what I'm pointing to.
Withdrawals come with this. Keep in mind the half life of nicotine is 1 to 2 hours.
Claiming it has no addictive potential and currently recommending nicotine in relation to other adaptive substance is what seems pointless imo.
Addiction is a concern I had when reading the pros and cons as I was experimenting with nicotine. But there's a lot of assumptions in some studies, and a lot of debate. Some concerns remained after my experience and some new ones arose, but addiction was definitely not one of them. If I had to blame anything relating to tobacco regarding addiction, I would blame some of the non-nicotine effects you find when smoking cigarettes (I carefully compared pure nicotine and smoking tobacco). Those can be extremely powerful mood and creativity stimulators. They are really awesome and stimulated my brain in the most Peaty way possible. And I can see how that could be addictive, because you want to continue to use it to be creative and sociable and so you return smoking as soon as things go down again. (Although I personally believe it is difficult to get addicted from smoking a couple cigs a day, which is the case of many smokers. Smoking studies are almost always about heavy chimney smokers, I don't think I need to remind anyone how biased some studies are...)
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