NLRP3 Inflammasome Cause Of Male Pattern Baldness

[BetterCallSaul]

It’s to do with unbound androgens, due to low SHBG.
Low SHBG is caused by insulin resistance/metabolic issues.
In women, this is PCOS.
As we age, SHBG drops too.

 

[GorillaHead]

It’s to do with unbound androgens, due to low SHBG.
Low SHBG is caused by insulin resistance/metabolic issues.
In women, this is PCOS.
As we age, SHBG drops too.

circulating androgens have little effect on the overall grand scheme of AGA. What I mean by that is. If u take a 50 year old castrate human being who has no balding but has balding genes and u inject them with androgen levels of an 18 year old. They will bald so fast as if they have been balding since puberty.


you Are neglecting all the evidence I just dropped. It’s profoundly by far the strongest argument to date. Ar transcription increases as we age and will increase due to numerous reasons and edar2 being the largest reason.

this is why there are studies that show AGA is caused by insulin resistance and there are studies that say there is no relation. Because ultimately this AR upregulation is caused by multiple things, obesity, and metabolic syndrome are by far one of the biggest causes of AR upregulation in certain tissues. It seems to increase with age overall and this increase is then compounded by serum androgens. So yes if ur androgen Levels increase from weight lifting even though ur insulin sensitivity is great but if your in your 30s its more likely to hurt your hair. PPAR GAMMA, RXR. OBESITY, METABOLIC SYNDROME And ALDOSTERONE will all increase balding expression. optimize these and balding should slow down but it def wont reverse imo.

 

[LeeLemonoil]

The problem with causalities is that we tend to understand them linear. But I’m physiology they are spread out, simultaneous, interconnected, self-reinforcing, circular, digital.

Take the SHGB issue, it’s always unclear what’s hen and egg. Nothing in our evolved organism is really redundant. So bound steroids fullfill a function but in some conditions unbinding occurs to compensate for something and another chain of events is set in motion

 

[GorillaHead]

The problem with causalities is that we tend to understand them linear. But I’m physiology they are spread out, simultaneous, interconnected, self-reinforcing, circular, digital.

Take the SHGB issue, it’s always unclear what’s hen and egg. Nothing in our evolved organism is really redundant. So bound steroids fullfill a function but in some conditions unbinding occurs to compensate for something and another chain of events is set in motion

Sure. I mean yes having more circulating androgens is gonna be bad its more fuel to the fire but the cause of the fire here is nuclear AR transcription on A tissue based level resulting in stronger androgen expression

 

[Ras]

For those that believe it isn't somewhat due to hormones:


View: https://twitter.com/kcmiller1225/status/1579132480975941633

 

[Inaut]

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

Thymol, a bioactive monoterpene isolated from Thymus vulgaris, has displayed inspiring neuroprotective properties. The present study was designed to e…

www.sciencedirect.com

 

[334c]

For those that believe it isn't somewhat due to hormones:


View: https://twitter.com/kcmiller1225/status/1579132480975941633

could it be that the hrt is causing a progesterone deficiency in them?

I wonder what hormones they are taking. would anybody here know?

if its only androgens then it could be converting to estrogen, while theyd also have lower progesterone levels

thats my speculation

 

[ivy]

The Young / old comparison helps a lot.

MPB is senescence. Means, an anti-cancer mechanism when more functional anti-cancer mechanism fail.

Hairloss in young women has other causes

could it be that the hrt is causing a progesterone deficiency in them?

I wonder what hormones they are taking. would anybody here know?

if its only androgens then it could be converting to estrogen, while theyd also have lower progesterone levels

thats my speculation

All female to male transitioners take testosterone. There's no replacement per say, there's an overriding. Not sure whether she took puberty blockers before that, she has given long format interviews to Benjamin Boyce and others, in case you're interested. AGA is a very common feature in this population after testosterone supplementation.

 

[Mauritio]

Klotho might be helpful here.
Its anti-inflammatory in at least 4 or 5 ways.

Klotho controls the brain-immune system interface in the choroid plexus - PubMed

Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally...

pubmed.ncbi.nlm.nih.gov

 

[BrianF]

Klotho might be helpful here.
Its anti-inflammatory in at least 4 or 5 ways.

Klotho controls the brain-immune system interface in the choroid plexus - PubMed

Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally...

pubmed.ncbi.nlm.nih.gov

And how would you in increase the production of Klotho?

 

[David PS]

And how would you in increase the production of Klotho?

i had the same question.

Klotho: Become Smarter And Live Longer With 50+ Ways To Increase Klotho — MyBioHack | Unlock Your Maximus Potential

Klotho may be one of our humans' natural adaptogens by its ability to help regulate cellular stress . In this post, we will discuss its role in longevity, muscle strength, cancer, cognition, and neurotransmitter balance.

mybiohack.com

 

[Mauritio]

And how would you in increase the production of Klotho?

Androgens and policosanol increase klotho.

 

[BrianF]

Androgens and policosanol increase klotho.

A good supply of policisanol other than supplements?

 

[Mauritio]

A good supply of policisanol other than supplements?

I think Bees wax or certain rums can be high in it. Check out the thread on it ,it was all discussed there at length. It's called "the policosanol thread".

 

[Inaut]

A good supply of policisanol other than supplements?

Panela and jaggery

 

[BrianF]

I think Bees wax or certain rums can be high in it. Check out the thread on it ,it was all discussed there at length. It's called "the policosanol thread".

Thanks Mauritio!

 

[Mauritio]

Klotho might be helpful here.
Its anti-inflammatory in at least 4 or 5 ways.

Klotho controls the brain-immune system interface in the choroid plexus - PubMed

Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood. For unknown reasons, the choroid plexus produces high levels of the protein klotho. Here, we show that these levels naturally...

pubmed.ncbi.nlm.nih.gov

Klotho influences the human hair cycle and klotho deletion in mice causes hair loss.

Expression Pattern and Role of Klotho in Human Hair Follicles

Klotho protein plays a pivotal role in aging regulation. However, it is unclear whether klotho is expressed in human hair follicles and is correlated with hair growth.The purpose of this study was to determine the expression pattern and role of klotho ...

www.ncbi.nlm.nih.gov

"Klotho-deficient mice display a complex phenotype reminiscent of human aging, including skin atrophy and hair loss."

"klotho silencing promoted premature catagen induction and inhibited human hair growth."

https://ir.ymlib.yonsei.ac.kr/handle/22282913/136698

 

[GorillaHead]

@Mauritio

Dont wsste ur time. Wont do anything. There is a master regulator of whats going on in mpb. Unless the root os addressed. Very few things can hijack the process

 

[Mauritio]

@Mauritio

Dont wsste ur time. Wont do anything. There is a master regulator of whats going on in mpb. Unless the root os addressed. Very few things can hijack the process

It's a red flag for me if someone speaks the way you do. Immediate skip.

 

[GorillaHead]

It's a red flag for me if someone speaks the way you do. Immediate skip.

Lol. Go ahead waste ur time.