So far I haven't really seen any profound regrowth stories on this forum (eg returning to dense nw1).
I think Danny and Ray are correct, though I wonder if someone who has a better understanding of biochemistry than i do could possibly integrate this guys theory into our bioenergetic view:
(i imagine its the subtle piece of the puzzle that allows some of us to revert multiple norwoods. maybe not idrk lol)
here's a really interesting comment on a Danny Roddy video:
1:
Mark Panbecker:
"It only took me 17 years and and about 50K pubmed abstracts to find out the SAME mechanism that causes gout ALSO is the same mechanism that causes male pattern baldness. Castration prevents both gout and mpb. The mechanism or VERY close is: NLRP3 inflammasome activation which involves casp1 activation(which is higher in mpb scalp). Problem with too much casp1 is that it cleaves(chews up) the glucocorticoid receptor. Inflammation and autoimmunity are well known with NLRP3 activation. Without glucorticoid receptor function(I believe) you get AR upreg stepping in as a surrogate for a dysfunctional GC receptor. Glucocorticoid resistance is THEE major problem in hair loss. Autophagy prevents the NLRP3 cascade. That's why you see also babies sometimes born like a mpb shape even in girls because sometimes the mother has high GC levels in late term."
- I saw in a Peat facebook group a woman claiming her husband growing his hairline back after fasting
- casp1 in aga scalps study Caspase-1 level is higher in the scalp in androgenetic alopecia - PubMed
- this may explain some of the finasteride/ mtf transition successful regrowth
- its been mentioned on this forum that a finasteride user kept great hair but aged poorly in other ways
- could this mean there is a very specific type of inflammation cascade occuring in the scalps of balding men?
- some hypothyroid people maintain really great hair. Some people recover their stress/thyroid health to ideal / hyper yet struggle to gain significant regrowth
- in other words, could this make sense of how some unhealthy people can keep great hair?
2:
"Mark Panbecker4 years ago
Read this link about lyme disease(activates NLRP3) and male pattern baldness initiation. https://www.nczonline.net/blog/2014/04/02/i-have-lyme-disease/ Also immortal hair has some college guys suddenly develop mpb in their mold filled apartment. NLRP3 activated by microbes, cholesterol crystals, low PH, numerous things."
- a possible connection with Danny - genetically some have stress physiology that is susceptible to this "NLRP3 cascade"
- btw im not suggesting castration as a solution lmao, maybe there is some peaty method that should be doubled down on in particular to allow sufficient / youth like autophagy of "NLRP3 inflammasome" (?)
3:
"Mark Panbecker3 years ago
I never said GOUT was the cause of mpb. NLRP3 is the key pathway to look at for gout and mpb.Castration cures both. Autophagy (lack of it) it the real problem because dht downregulates it thru microRNA 221. Autophagy stops the nlrp3 from firing. Look at all drugs that cause hair growth just "happen" to increase autophagy."
possibly related forum thread?: Hair Regrowth After Glucocorticoids - Any Ideas Why?
dafaq?
Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture
Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture
link to the Danny Roddy video where you can find the discussion towards the bottom of the comment section:
(sorry if my writing is scattered)
surely we can solve MPB completely and for good. (Btw i like to imagine that if the Ray Peat / pro metabolic community can legitimately surpass the mainstream big 3 'treatments' - itd lead to a huge awakening in the masses view of mainstream pharmaceuticals/thyroid/scientism)
id love to hear what you folks think of this.
I think Danny and Ray are correct, though I wonder if someone who has a better understanding of biochemistry than i do could possibly integrate this guys theory into our bioenergetic view:
(i imagine its the subtle piece of the puzzle that allows some of us to revert multiple norwoods. maybe not idrk lol)
here's a really interesting comment on a Danny Roddy video:
1:
Mark Panbecker:
"It only took me 17 years and and about 50K pubmed abstracts to find out the SAME mechanism that causes gout ALSO is the same mechanism that causes male pattern baldness. Castration prevents both gout and mpb. The mechanism or VERY close is: NLRP3 inflammasome activation which involves casp1 activation(which is higher in mpb scalp). Problem with too much casp1 is that it cleaves(chews up) the glucocorticoid receptor. Inflammation and autoimmunity are well known with NLRP3 activation. Without glucorticoid receptor function(I believe) you get AR upreg stepping in as a surrogate for a dysfunctional GC receptor. Glucocorticoid resistance is THEE major problem in hair loss. Autophagy prevents the NLRP3 cascade. That's why you see also babies sometimes born like a mpb shape even in girls because sometimes the mother has high GC levels in late term."
- I saw in a Peat facebook group a woman claiming her husband growing his hairline back after fasting
- casp1 in aga scalps study Caspase-1 level is higher in the scalp in androgenetic alopecia - PubMed
- this may explain some of the finasteride/ mtf transition successful regrowth
- its been mentioned on this forum that a finasteride user kept great hair but aged poorly in other ways
- could this mean there is a very specific type of inflammation cascade occuring in the scalps of balding men?
- some hypothyroid people maintain really great hair. Some people recover their stress/thyroid health to ideal / hyper yet struggle to gain significant regrowth
- in other words, could this make sense of how some unhealthy people can keep great hair?
2:
"Mark Panbecker4 years ago
Read this link about lyme disease(activates NLRP3) and male pattern baldness initiation. https://www.nczonline.net/blog/2014/04/02/i-have-lyme-disease/ Also immortal hair has some college guys suddenly develop mpb in their mold filled apartment. NLRP3 activated by microbes, cholesterol crystals, low PH, numerous things."
- a possible connection with Danny - genetically some have stress physiology that is susceptible to this "NLRP3 cascade"
- btw im not suggesting castration as a solution lmao, maybe there is some peaty method that should be doubled down on in particular to allow sufficient / youth like autophagy of "NLRP3 inflammasome" (?)
3:
"Mark Panbecker3 years ago
I never said GOUT was the cause of mpb. NLRP3 is the key pathway to look at for gout and mpb.Castration cures both. Autophagy (lack of it) it the real problem because dht downregulates it thru microRNA 221. Autophagy stops the nlrp3 from firing. Look at all drugs that cause hair growth just "happen" to increase autophagy."
possibly related forum thread?: Hair Regrowth After Glucocorticoids - Any Ideas Why?
dafaq?
Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture
Autophagy is essential for maintaining the growth of a human (mini-)organ: Evidence from scalp hair follicle organ culture
link to the Danny Roddy video where you can find the discussion towards the bottom of the comment section:
(sorry if my writing is scattered)
surely we can solve MPB completely and for good. (Btw i like to imagine that if the Ray Peat / pro metabolic community can legitimately surpass the mainstream big 3 'treatments' - itd lead to a huge awakening in the masses view of mainstream pharmaceuticals/thyroid/scientism)
id love to hear what you folks think of this.