palmitoleic acid , a type of fatty acid in butter and animal fat(ruminant),
Effect of Cis-palmitoleic acid (an omega-7 fatty acid) supplementation on inflammation and expression of HNF4γ, HNF4α and IL-6 in patients with ulc... - PubMed - NCBI
Abstract
BACKGROUND:
Cis-palmitoleic acid (Omega-7 fatty acid) is a monounsaturated fatty acid (MUFA) associated with anti-inflammatory process through specific protein interactions such as HNF4 gamma and HNF4 alpha , these two genes are related to the immune response in ulcerative colitis (UC) they may act as a mediator of anti- inflammatory action. The aim of this study was to evaluate the effect of Cis- palmitoleic acid supplementation on inflammatory activity and the expression of genes HNF4 gamma , HNF4 alpha and IL-6 in the colonic mucosa of patients with active UC.
METHODS:
A double-blind, randomized, placebo-controlled pilot study was conducted in 20 patients with UC. A dose of 720 mg/day of Cis-palmitoleic acid was orally administered during 8 weeks and Mayo Clinic score was used for the assessment of clinical activity in UC before and after treatment with Cis-palmitoleic acid and placebo.
RESULTS:
A total of 20 patients with UC were randomized to receive Cis-palmitoleic acid or placebo. Significant changes in the biochemical markers of inflammation were found in UC patients before and after treatment with Cis-palmitoleic acid vs placebo such as total protein (P=0.02), hs-CRP (P=0.04) and ESR (P<0.05). The gene expression of HNF4γ and HNF4 alpha were found to be increased in the Cis-palmitoleic acid group compared to placebo group (P=0.05 and P=0.07 respectively) as well as significant reduction upon IL-6 expression in the Cis-palmitoleic acid group (P=0.005).
CONCLUSIONS:
Cis-palmitoleic acid as co- adjuvant therapy for 8 weeks seems to decrease the inflammatory activity through the increased expression of HNF4 alpha and HNF4 gamma in patients with UC.
Effect of Cis-palmitoleic acid (an omega-7 fatty acid) supplementation on inflammation and expression of HNF4γ, HNF4α and IL-6 in patients with ulc... - PubMed - NCBI
Abstract
BACKGROUND:
Cis-palmitoleic acid (Omega-7 fatty acid) is a monounsaturated fatty acid (MUFA) associated with anti-inflammatory process through specific protein interactions such as HNF4 gamma and HNF4 alpha , these two genes are related to the immune response in ulcerative colitis (UC) they may act as a mediator of anti- inflammatory action. The aim of this study was to evaluate the effect of Cis- palmitoleic acid supplementation on inflammatory activity and the expression of genes HNF4 gamma , HNF4 alpha and IL-6 in the colonic mucosa of patients with active UC.
METHODS:
A double-blind, randomized, placebo-controlled pilot study was conducted in 20 patients with UC. A dose of 720 mg/day of Cis-palmitoleic acid was orally administered during 8 weeks and Mayo Clinic score was used for the assessment of clinical activity in UC before and after treatment with Cis-palmitoleic acid and placebo.
RESULTS:
A total of 20 patients with UC were randomized to receive Cis-palmitoleic acid or placebo. Significant changes in the biochemical markers of inflammation were found in UC patients before and after treatment with Cis-palmitoleic acid vs placebo such as total protein (P=0.02), hs-CRP (P=0.04) and ESR (P<0.05). The gene expression of HNF4γ and HNF4 alpha were found to be increased in the Cis-palmitoleic acid group compared to placebo group (P=0.05 and P=0.07 respectively) as well as significant reduction upon IL-6 expression in the Cis-palmitoleic acid group (P=0.005).
CONCLUSIONS:
Cis-palmitoleic acid as co- adjuvant therapy for 8 weeks seems to decrease the inflammatory activity through the increased expression of HNF4 alpha and HNF4 gamma in patients with UC.