Pansterone - Liquid Pregnenolone/DHEA Mix

[haidut]

So pansterone has a significantly higher transdermal absorptionr ate than say, pregnenelone/dhea powder mixed with coconut oil? What percentage of the actives in pansterone would you say are aborbed and over what period of time? Interested to know these stats thanks

I posted this thread on steroids dissolved in DMSO basically having the same bioavailability as subcutaneous administration (which is close to 100%).
Enhanced Bioavailability And Tissue Effects Of Steroids Dissolved In Dmso | Ray Peat Forum

As you can see from some of the quotes, estrogen dissolved in peanut oil had much lower absorption, so I am inclined to think that other steroids dissolved in oil will similarly fare worse then ones dissolved in DMSO.

 

[tca300]

I posted this thread on steroids dissolved in DMSO basically having the same bioavailability as subcutaneous administration (which is close to 100%).
Enhanced Bioavailability And Tissue Effects Of Steroids Dissolved In Dmso | Ray Peat Forum

As you can see from some of the quotes, estrogen dissolved in peanut oil had much lower absorption, so I am inclined to think that other steroids dissolved in oil will similarly fare worse then ones dissolved in DMSO.

Haidut, what do you think the shelf life is of PanSterone olive oil vitamin E version? Should I put it in the fridge? Thank you!!

 

[haidut]

Haidut, what do you think the shelf life is of PanSterone olive oil vitamin E version? Should I put it in the fridge? Thank you!!

No need to put in the fridge as it has quite a bit of vitamin E in it. If you leave it outside at room temp it will probably take several years for the olive oil to oxidize, maybe longer.

 

[asdfasdf]

Thanks so much for posting this! Indeed, given my recent posts on DMSO providing topical delivery effectiveness equivalent to subcutaneous application I would suspect Pansterone is about 10 times more effective than equivalent doses ORALLY. This explains why people seem to do best on 1-2 drop vs. the 8 drops per dose. I have unintentionally introduced a product that is much more bioavailable than I initially thought, and as such can last people much longer:)

How about taking Pansterone orally? Is the dose size the same? Would 8 drops in the tea with breakfast work?

 

[haidut]

How about taking Pansterone orally? Is the dose size the same? Would 8 drops in the tea with breakfast work?

The dose is the same but I cant officially endorse oral use. However, many people report taking it orally and getting similar results to topical use.

 

[dfspcc20]

FYI- my experience so far. I've been using 2-3 drops of Pansterone, a few times a week, on my skin. Libido and sleep might be improved- hard to say at this point, as those have typically waxed and waned for me in the past. One thing I have observed is my urine is noticeably darker. I wasn't excessively urinating before (maybe 5-6x/day), it was usually a light yellow color. Now it's more dark, maybe a bit towards orange. This is w/o supplementing extra riboflavin or anything. I'm thinking that might be a sign of improved metabolism (at least according to some of Matt Stone's writing).
I should have been paying better attention to temps and pulse before and after, but I neglected gathering that data.

 

[tara]

Now it's more dark, maybe a bit towards orange.

Maybe time drink a bit more?

 

[Darnielle]

Hi there have you shipped to new Zealand?

 

[haidut]

Hi there have you shipped to new Zealand?

Yes, we have shipped to New Zealand before and usually do every month. So far, no issues with delivery.

 

[Darnielle]

Yes, we have shipped to New Zealand before and usually do every month. So far, no issues with delivery.

Yus thank you hope it arrives can't wait to try this

 

[barefooter]

30 year old male here, just wanted to post my results with pansterone. I've been using 8 drops 3x/day for a week now, and it is having some pretty dramatic effects. Overall I just feel a lot better, more energy, higher libido, more social, better in the gym, and I just feel more confident and alpha. It also seems to be bringing my body temp up a bit, and I'm now much more likely to be in the low 98s in the afternoon, whereas before I was always around 97.8. But the thing that is most pleasing to me, is that it seems to be pretty quickly reversing a kind of mild persistent paranoid state I'd been in for the past year or so. A year ago I had some bad drug trips, and a few months ago I had some of my first panic attacks. The panic attacks went away with eating more, but I was left with a lingering feeling of just not being the same since all the bad experiences over the last year, sorta like a persistent fear about the nature of reality and being alive.

I've been reading a bit recently about DHEA/cotrisol ratio and panic attacks, so I wonder if that was at play. I had my DHEA tested before starting pansterone, and I should have the results back soon, so it will be interesting to see how low it was.

Thanks for this great supplement @haidut

 

[haidut]

30 year old male here, just wanted to post my results with pansterone. I've been using 8 drops 3x/day for a week now, and it is having some pretty dramatic effects. Overall I just feel a lot better, more energy, higher libido, more social, better in the gym, and I just feel more confident and alpha. It also seems to be bringing my body temp up a bit, and I'm now much more likely to be in the low 98s in the afternoon, whereas before I was always around 97.8. But the thing that is most pleasing to me, is that it seems to be pretty quickly reversing a kind of mild persistent paranoid state I'd been in for the past year or so. A year ago I had some bad drug trips, and a few months ago I had some of my first panic attacks. The panic attacks went away with eating more, but I was left with a lingering feeling of just not being the same since all the bad experiences over the last year, sorta like a persistent fear about the nature of reality and being alive.

I've been reading a bit recently about DHEA/cotrisol ratio and panic attacks, so I wonder if that was at play. I had my DHEA tested before starting pansterone, and I should have the results back soon, so it will be interesting to see how low it was.

Thanks for this great supplement @haidut

This is great news! I think the effects of both pregnenolone and DHEA on the panic centers in the brain can be pretty dramatic. I posted a study recently showing pregnenolone was the most potent endogenous inhibitor of CRH, which is the primary driver of the panic response. If you do any blood tests while taking it please share with the forum.
Thanks again and so glad you are feeling better!

 

[Lucas]

Hello.
I have some doubts about Dhea therapy:

I have low serum Dhea-S. Taking Pansterone will up my levels. After my levels of Dhea-S go to normal, should I take Dhea and Pregnolone forever to keep these levels?

Can be low Dhea-S the reason I don’t tolerate Thyroid medication?

Is high Cortisol and Low Dhea-S the same as adrenal insufficiency?

 

[haidut]

Hello.
I have some doubts about Dhea therapy:

I have low serum Dhea-S. Taking Pansterone will up my levels. After my levels of Dhea-S go to normal, should I take Dhea and Pregnolone forever to keep these levels?

Can be low Dhea-S the reason I don’t tolerate Thyroid medication?

Is high Cortisol and Low Dhea-S the same as adrenal insufficiency?

Hi Lucas. I think you should ask these questions in a separate thread. As far as Pansterone is concerned, I think most people who take it long term take it sporadically. If DHEA levels decline with age while cortisol levels remain the same or unchanged, the DHEA/cortisl ratio will drop. There is a lot of research showing that optimal health is correlated with DHEA/cortisol levels found in a 25-year old males/females. So, for people whose DHEA levels go down with age, some supplementation with either Pansterone or thyroid + cholesterol may be needed to maintain optimal levels.

 

[barefooter]

This is great news! I think the effects of both pregnenolone and DHEA on the panic centers in the brain can be pretty dramatic. I posted a study recently showing pregnenolone was the most potent endogenous inhibitor of CRH, which is the primary driver of the panic response. If you do any blood tests while taking it please share with the forum.
Thanks again and so glad you are feeling better!

Well, I guess my positive outcome makes a lot of sense than. I'll have to checkout that research study. I'm planning to get DHEA, prolactin, and testosterone tested again in a couple months to compare to my pre-supplementation results. I'll definitely post the results when I do it.

 

[equusvult]

Haidut, I purchased some pansterone and used about a 3rd of it before I noticed some participate collecting at the bottom of bottle. I now shake before use, but was wondering if I have inadvertently changed the ratio of contents, and I should just toss it and start fresh with new bottle??

I have mentioned a few times on the forum that I have an upcoming supplement consisting of a combination of pregnenolone and DHEA. I am calling it PanSterone (the "pan" word meaning all) as it stands for a precursor to all other steroids. The benefits of pregnenolone are well known to the Ray Peat community and have been discussed by Peat many times. Some of the more important effects of pregnenolone include enhancing memory, mood, skin health and in general protecting the body from stress and various toxins. So, pregnenolone is a catatoxic steroid of youth - helping with detoxification. DHEA is another catatoxic steroid of youth and its levels also decline with age. Ray has written about some of the benefits of DHEA but has not provided as much detail as he has on his favorite steroid progesterone. So, I have provided some additional information on DHEA below.
So, why use a combination of pregnenolone and DHEA? I have reviewed a number of studies and conducted my own experiments that show pregnenolone to enhance the effects of whatever steroid it is co-administered with. In addition, DHEA inhibits the conversion of pregnenolone through the pathways that lead to cortisol or DHEA itself. So, in effect DHEA (taken on its own or especially when co-administered with pregnenolone) will increase the conversion of pregnenolone into progesterone. This provides a very effective alternative of raising progesterone (and thus keeping estrogen at bay) than supplementing progesterone directly. Here are some quotes from a study that first alerted me to to the benefits of combining pregnenolone with other steroids.

Pregneolone--from Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptor. - PubMed - NCBI
"...PREG can go directly to progesterone and thence to aldosterone (route A, Fig. 2) or to 17~0H
PREG, which is a precursor for cortisol formation (route B, Fig. 2) and for sex-related steroids (route
C, Fig. 2). Route A can contribute to route B and route B to route C, as shown. DHEA, the first product in route C, can inhibit the flow through routes B and C by inhibiting conversion of PREG to 17a-OH PREG. PREG is of major interest because it lies at the branchpoint at which decisions are made as to how the subsequent metabolic flow is fractionated between the mineralocorticoid, androgen + estrogen, and glucocorticoid pathways."

"...Long before any of the details of its metabolism had been worked out, PREG was being tested for effects in animals and in humans. Early on after its synthesis, PREG was tested in animals for estrogenic, progestational, and adrenal cortical activity with negative results. Selye’s subsequent work with rats, performed only under unusual experimental conditions with high doses of PREG, made it possible to attribute a number of classical hormonal actions to PREG, none of them particularly impressive [24-26]. However, Selye’s remarkably intuitive interpretation of his data and his suggested scheme for a possible route of biogenesis of the different types of hormonal steroids presaged current biochemical knowledge by several years: “It is very probable that the inability of ‘earlier workers to detect these manifold activities of PREG was due to the fact that in most respects the compound is quantitatively not very potent. It distinguishes itself from other steroids, however, because it possesses so many different activities. Thus the compound possesses-at least in traces-every independent main pharmacological action which has hitherto been shown to be exhibited by any steroid hormone. In the light of these observations it was tempting to speculate on the possible role of the compound as an undifferentiated hormone-precursor from which the organism may-according to its needs-produce compounds in which one effect is particularly developed at the expense of other activities of the multipotent parent substance.”

"...It may be imagined that PREG, the parent steroid, also can play synergic roles with other steroids at genomic and non-genomic sites, facilitating their actions in helper-like fashion through allosteric effects exerted by binding at different loci to the same entities."

"...Restoration of normal steroid patterns by administration of PREG alone or together with much smaller than currently employed amounts of other steroids is likely to be less physiologically disturbing than is administration of arbitrarily selected amounts of more potent substances that derive from it, e.g. cortisone, sex steroids, or aldosterone, because myriad feedback inhibitory loci exist in steroid formation beginning with the synthesis of PREG from cholesterol, which in different tissues may be under the control of different pituitary hormones, and because there exists widespread competition of steroids for binding to receptor and allosteric sites."

"...In some instances in which sex hormones are required, it might be better to give PREG and DHEA rather than to administer the sex hormones, themselves. DHEA is a normally occurring precursor of androgens, which in turn are precursors for estrogens. Upon penetration of DHEA and PREG to androgen or estrogen- synthesizing sites in the various tissues, conditions existing at these sites would determine quantities and rates of androgen and estrogen synthesis. Presumably, the presence of PREG would allow smaller amounts of DHEA to be given to achieve a particular effect than without it, because PREG could serve as precursor of indigenous synthesis of DHEA as well as possibly play a helper role, as suggested above."

"...In those instances in which desired therapeutic goals cannot be attained without actual administration of the sex steroids, themselves, co-administration of PREG with relatively small amounts of sex steroids might give the same physiological effects as would administration of larger amounts of the latter alone. This would minimize risk of feedback inhibition of formation and/or release of pituitary factors that play a role in steroid hormone synthesis and thus attenuate the consequent homeostatic disturbance that would occur upon cessation of administration of steroid or a reduction in dosage."

Another question - why use DMSO? Well, in addition to its unparalleled features as a carrier through the skin, DMSO seems to potentiate the activity of steroids, thus increasing the effects of pregnenolone, DHEA and more importantly their metabolites such as DHT and androstenediol.
Dimethyl sulfoxide - Wikipedia, the free encyclopedia
"...DMSO is thought to increase the effects of blood thinners, steroids, heart medicines, sedatives, and other drugs."

Yet another question - why favor topical administration? There are several reasons but the most important ones are that topical administration of steroids like DHEA increase both their half-life and effectiveness. In addition, topical administration of DHEA has been shown to favor the androgenic pathways of conversion, thus reducing even further concerns about potential estrogenicity of DHEA. With topical application of a single dose of Pansterone, a person is probably getting the same effects as 100mg+ oral DHEA and WITHOUT the estrogenic side effects. Here are some additional sources discussing these issues.
http://examine.com/supplements/dehydroe ... summary3-0
"...Interestingly, no differences were seen in circulating DHEA, testosterone or estrogen levels between the cream or gel yet the cream resulted in significantly higher androstenedione concentration at 24 hours and topical administration in general favored androgen metabolism more than oral administration."
"...Topical administration also shows larger blood values of hormones over a period of days; although suggestive of a potentiating effect, this may be due to the effects of DHEA applied topically lasting more than 24 hours.[31] Over a period of 12 months, serum levels of daily application are similar to those seem when measured at 28 days."
"...Topical administration appears to have comparable overall bioavailability (percent hitting the bloodstream) when compared to oral ingestion. Topical seems to influence androgens like testosterone more than oral ingestion, and although there are no differences in the short term DHEA cream appears to be better than DHEA gel."

High bioavailability of dehydroepiandrosterone administered percutaneously in the rat. - PubMed - NCBI
"...By the oral route, on the other hand. DHEA has only 10-15% of the activity of the compound given percutaneously. Taking the bioavailability obtained by the subcutaneous route as 100%, it is estimated that the potencies of DHEA by the percutaneous and oral routes are approximately 33 and 3% respectively."

The last quote above effectively states that topical Pansterone is about 6-10 times more potent as oral.

WARNING: It is crucial not to exceed 15mg total DHEA daily dose use even with topical administration. This amounts to using no more than 3 daily doses of Pansterone. The reason for this restriction is that even with topical administration, human studies found that estrogen went up when the total daily dose of DHEA exceeded 18mg (6g of a 0.3% DHEA cream). Here is a study showing that effect:
http://www.hormonebalance.org/images/do ... 20JSBM.pdf
"...Serum estradiol (E2) followed a comparable pattern with the first significant increase being seen at the 0.3% DHEA cream concentration."


Here is the official description I placed in the online stores together with the scientific references.
I would appreciate any thoughts and comments. Thanks in advance.
***************************************************************************************************************************************************************************************************************************************************************************************************************************************************************************************************
Pansterone contains a mixture of the "steroids of youth" - pregnenolone and DHEA - as discussed by Ray Peat in many of his articles. While each of the steroids has benefits on its own, the combination of these steroids in the doses used in the supplement have been found to amplify each other's beneficial effects on virtually all systems and organs in the human body. Some of the better known effects of these steroids include stress reduction, memory support, metabolism support, weight support, blood sugar support, immune system support, bone support, skin health and anti-aging, vision support, hair and nails support, libido and sexual function (in both sexes) and feelings of overall healthiness and resilience.

Servings per container: about 90
Each serving (8 drops) contains the following ingredients:
Pregnenolone - 5mg
DHEA (dehydroepiandrosterone) - 5mg

Other ingredients: DMSO, 20% ethanol
The product is intended and sanctioned for external use only.

The recommended method of administration is using the built-in dropper to place 8 drops on a body part (preferably without hair) and then rub it in gently. The dose can be taken up to 3 times daily for a total of 15mg pregnenolone and 15mg DHEA daily. Do not apply more than a single dose at a time since DHEA can easily turn into estrogen if the dose is too high, even though the added pregnenolone should greatly mitigate that effect.

TOPICAL ABSORPTION OF STEROIDS (FOCUS ON PREGNENOLONE):
http://www.nature.com/jid/journal/v52/n ... 19699a.pdf
Investigations on changes in ¹³C/¹²C ratios of endogenous urinary steroids after pregnenolone administration. - PubMed - NCBI
http://journal.scconline.org/pdf/cc1972 ... p00521.pdf
"...Skin permeability of the other steroids in the series (progesterone, pregnenolone, hydroxypregnenolone, hydroxyprogesterone, cortexone, testosterone, cortexolone, corticosterone, cortisone, hydro-cortisone and aldosterone) were of an intermediate degree between that of oestrone and hydrocortisone."

BENEFITS OF DHEA:
____________________________________________________________________________________________
-- DHEAS may not freely convert to DHEA in men—therefore important to take DHEA sublingually or transdermally (Hammer, 2005) Woman seem to convert DHEAS to DHEA better than men (Legrain, 2000)

-- Decline in DHEA levels with age associated with atrophy of the zona reticularis in the adrenal gland. (Dharia 2004)

-- DHEA protects against postmenopausal osteoporosis (Adachi 2006) (Haden 2000) (Osmanagaoglu 2004)

-- DHEA supplementation improves bone turnover and skin quality in older women (Baulieu 2000), reduces insulin levels and improves cholesterol levels (Lasco 2001)

-- DHEA supplementation improves mood and memory (Alhaj 2005)

-- DHEA has anti-cortisol and anti-diabetic effects (Apostolova 2005) (Diamond 1996)
-- DHEA supplementation improves ovarian function and pregnancy rates in older women (Barad 2007)

-- Low DHEAS levels associated with higher mortality and heart disease (Barrett-Conner 1986) (Glei 2006)

-- Low DHEAS associated with worse atherosclerosis. (Herrington 1995)

-- DHEA supplementation in men improves endothelial dysfunction, insulin sensitivity, and reduces pro-clotting mechanisms (plasminogen activator inhibitor type 1 concentration) (Kawano 2003) DHEA has anti-atherosclerotic effects (Martina 2006)

-- DHEA reduces LDL (bad) cholesterol, insulin, and glucose levels in men with coronary artery disease. (Rabijewski 2005)

-- “DHEA is an integral part of LDL and HDL and exerts an anti-oxidative effect on LDL. Since oxidative modifications of LDL enhance their atherogenicity, DHEA could have anti-atherogenic consequences.” (Khalil 2000)

-- DHEA reduces platelet aggregation (Jesse 1995)

-- Low DHEA levels correlated with incident ischemic heart disease (Feldman 2001) (Mitchell 1994)

-- DHEA supplementation reduces visceral fat—which is one aspect of the metabolic syndrome (Villareal 2004)

-- DHEA works to inhibit the atherosclerotic process or thrombus formation. Studies have shown that DHEA can oppose LDL oxidation, plaque formation, cell proliferation, platelet aggregation, and plasminogen activation (see refs.).

-- Low DHEAS associated with functional limitations and mortality in older persons (Berr 1996)

-- DHEA prevents the biomolecular complications of diabetes (Brignardello 2007)

-- In mid-life dysthymia (depression), DHEA works as well as anti-depressants (Bloch, 1999)

-- DHEA enhances insulin sensitivity and lowers triglycerides levels (Casson 1995) (Dhatariya 2005)

-- DHEA supplementation improves natural killer cells numbers and lowers IL-6 (Casson 1993) (Daynes 1993) (Haden 2000)

-- DHEA supplementation reduces IL-10 in lupus patients (Chang 2004)

-- DHEA is an effective treatment for inflammatory bowel disease (Andus 2003), and systemic lupus erythematosis (FDA-approved for this disease, see Petri 2004)

-- “DHEA is more than a more than a simple "diet supplement" or "antiaging product"; rather it should be considered an effective hormonal replacement treatment.” (Genazzani 2001)

-- Anorexics have low DHEA, supplementation improved bone density and mood scores (Gordon 2002)

-- DHEAS levels are lower in autism (Strous, 2005)

-- Most patients with CFS had a serum dehydroepiandrosterone sulfate (DHEA-S) deficiency. (Kuratsune 1998)

-- DHEA supplementation improves sexual function in women (Hackbert 2002) (Johannsson 2002)

-- Frail elderly subjects have lower DHEAS and IGF-1 levels than non-frail (Leng 2004)

-- DHEA supplementation markedly increased perceived physical and psychological well-being in older men and women. (Morales 1994)

-- DHEA prevents induced mammary carcinoma in rats, and increases bone mass.

-- No known receptor, no known feedback mechanism—DHEA supplementation does not reduce natural production.

-- DHEAS levels are reduced in chronic inflammatory diseases and DHEA should be given to any patient requiring glucocorticoid treatment for these diseases.(Straub 2000)

-- Improves fertility in older women (Barad 2007)

-- DHEAS levels also affect hematocrit—higher DHEAS give greater rise in hematocrit with altitude (Lee 2006)

-- DHEAS levels are low in schizophrenia and supplementation improves the negative symptoms. (Wolkowitz 1997, Strous 2005)

-- DHEAS levels are low in depressed patients (Heinz 1999). DHEA improves depression in AIDs patients (Rabkin 2006), and in adults with major depression (Schmidt 2005)

-- “DHEA is a highly effective tumor chemopreventive agent in laboratory mice and rats.” (Hastings 1988)

-- DHEA restores beta-endorphin levels which can help with pain and modulate the secretion of other hormones. (Stomati 1999)

-- Low DHEAS associated with risk of heart disease in post-menopausal women (Sablik

-- DHEA administration lowers cortisol levels (Kroboth 2003)

-- DHEA should be given to all patients on glucocorticoids to counteract their negative effects (Robinzon 1999)

-- In women with hypoactive sexual disorder, low DHEAS, not testosterone, was associated with symptoms. (Basson, 2010)

-- Daily intravaginal DHEA administration at DHEA doses of 3.25-13 mg was able to rapidly and efficiently achieve correction of all the signs and symptoms of vaginal atrophy and improve sexual function and caused no or minimal changes in serum sex steroid levels (Labrie, 2009)[/list]



BENEFITS OF PREGNENOLONE:
____________________________________________________________________________________________
http://journal.scconline.org/pdf/cc1967 ... p00562.pdf
Activation of Pregnane X Receptor by Pregnenolone 16 α-carbonitrile Prevents High-Fat Diet-Induced Obesity in AKR/J Mice
[Effect of pregnenolone-16 alpha-carbonitrile on the activity of the rat thyroid gland and anterior pituitary]. - PubMed - NCBI
The Relationship of Allopregnanolone Immunoreactivity and HPA-Axis Measures to Experimental Pain Sensitivity: Evidence for Ethnic Differences
[Age-related changes in blood concentration of hypothalamic-pituitary-adrenal axis hormones, their central and peripheral regulators in healthy men]. - PubMed - NCBI
http://www.if-pan.krakow.pl/pjp/pdf/2006/3_335.pdf
Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient... - PubMed - NCBI
http://www.ncbi.nlm.nih.gov/pubmed/21094889
http://www.ncbi.nlm.nih.gov/pubmed/15585350
http://www.ncbi.nlm.nih.gov/pubmed/14611866
http://www.ncbi.nlm.nih.gov/pubmed/11744095
http://www.ncbi.nlm.nih.gov/pubmed/11534985
http://www.ncbi.nlm.nih.gov/pubmed/9748538
http://www.ncbi.nlm.nih.gov/pubmed/9405705
http://www.ncbi.nlm.nih.gov/pubmed/1531874

 

[haidut]

Haidut, I purchased some pansterone and used about a 3rd of it before I noticed some participate collecting at the bottom of bottle. I now shake before use, but was wondering if I have inadvertently changed the ratio of contents, and I should just toss it and start fresh with new bottle??

Did you keep it in the fridge or some other place cold? This is the first time I am hearing about Pansterone precipitating. Is it a cloudy white substance at the bottom of the bottle? If yes, then you can simply heat the bottle for a few seconds in the microwave and it will re-solve again. But make sure it is only 5-10 sec, you don't want to melt the bottle. Alternatively, you can open the bottle, pour the liquid in a heat resistant glass container, microwave for 10sec, wait to cool and pour back into the bottle. Or, you can just pour some hot water from the faucet in a water glass, then drop the closed bottle of Pansterone for a few minutes inside the hot water glass, then shake and it should dissolve again.

 

[equusvult]

Yes its a pretty small amount of a white cloudy substance at the bottom. I was just making sure after using 1/3 of the bottle, I'm still getting the proper ratio so as not to o.d. on dhea.. Should I order a new bottle just to be sure?

 

[Darnielle]

Hi there,

Can Pansterone help to increase lean muscle mass?

 

[haidut]

Yes its a pretty small amount of a white cloudy substance at the bottom. I was just making sure after using 1/3 of the bottle, I'm still getting the proper ratio so as not to o.d. on dhea.. Should I order a new bottle just to be sure?

You are not going to OD on DHEA. The amounts are pretty small. I would just warm up the bottle in a glass of hot water and shake for 30sec. Even if you don't warm it up and just shake before use so that the entire liquid becomes clowdy, it would still work. DMSO can get almost anything through the skin.