Protien restriction extends lifespan studies

[Samurai Drive]

Hello,
Rays last communications were based on protien restriction, methianine particularly. We all know why.

I watched an interview yesterday with a pro protien doc that refutes these studies. Claiming the restriction has context to what it was restricted from.
Does anyone have the original study data to review. I cant seem to find.

 

[GTW]

The main finding of our work is that BCAA can directly trigger a mechanism that involves oxidative stress and NF-κB activation in circulating PBMCs, and therefore these aminoacids could contribute to the inflammatory process observed in different pathological conditions.>While studies have shown that calorie restriction extends lifespan, a closer look suggests it’s not the fasting itself that is beneficial, but rather the restriction of inflammatory amino acids. Less food also means you’re exposed to less endotoxin that promotes chronic systemic inflammationDespite the established association between elevated circulating BCAA and their deleterious effects, little is known about the capacity of BCAA to directly contribute to the pro-inflammatory and pro-oxidant status. 11 benefits of bentonite clay: How to use it and side effects

 

[GTW]

That's a quick and dirty clipboard dump related to the subject. And the link is completely irrelevant.
Other factoids:
Methionine and BCAA tend to be inflammatory.
Glycine, taurine, NAC, glutamine associated with anti-inflammatory effects.
In moderately fat adapted persons ketogenisis is not catabolic and ketone bodies are anti-inflammatory.

 

[DennisX]

Hello,
Rays last communications were based on protien restriction, methianine particularly. We all know why.

I watched an interview yesterday with a pro protien doc that refutes these studies. Claiming the restriction has context to what it was restricted from.
Does anyone have the original study data to review. I cant seem to find.

If you try protein restriction when you’re >65 you’ll develop sarcopenia and probably die from a fall

 

[GTW]

If you try protein restriction when you’re >65 you’ll develop sarcopenia and probably die from a fall

Nuts to that. Foolish speculation.
At any adult age net anabolism is close to zero. The protein you eat is catabolized, burned. On lower protein intake your body becomes more efficient with salvaging and remodeling proteins. MTOR, and all that.
Restriction is not by definition reduced consumption. It can also mean intermittent fasting and specifically reducing some dietary elements.
Systemic inflammation, elevated stress hormones, whatcha call them, accumulated secretory serotype senescent cells are the problem.

 

[DennisX]

Nuts to that. Foolish speculation.
At any adult age net anabolism is close to zero. The protein you eat is catabolized, burned. On lower protein intake your body becomes more efficient with salvaging and remodeling proteins. MTOR, and all that.
Restriction is not by definition reduced consumption. It can also mean intermittent fasting and specifically reducing some dietary elements.
Systemic inflammation, elevated stress hormones, whatcha call them, accumulated secretory serotype senescent cells are the problem.

That is utter BS not backed up by science. instead of giving bad info based on nothing why don’t you view some of Dr Peter Attia.videos on protein needs as you age.

 

[Mr Joe]

That's a quick and dirty clipboard dump related to the subject. And the link is completely irrelevant.
Other factoids:
Methionine and BCAA tend to be inflammatory.
Glycine, taurine, NAC, glutamine associated with anti-inflammatory effects.
In moderately fat adapted persons ketogenisis is not catabolic and ketone bodies are anti-inflammatory.

Pro:

Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation - PubMed

Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are essential amino acids implicated in glucose metabolism and maintenance of correct brain function. Elevated BCAA levels can promote an inflammatory response in peripheral blood mononuclear cells. However, there are no studies...

pubmed.ncbi.nlm.nih.gov

Anti :

Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages

The purpose of this study was to evaluate the anti-inflammatory and anti-genotoxic activity of branched-chain amino acids (BCAAs) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. BCAAs inhibited LPS-induced NO production, with 100 mM ...

www.ncbi.nlm.nih.gov

Protection of branched-chain amino acids against ischemic myocardial injury in rats - PubMed

The protective effects of Branched-Chain Amino Acids (BCAA) on ischemic myocardium in rats were studied. Thirty Wistar rats (15 female and 15 male) were randomly divided into 3 groups of 10 animals each. Group A: control; group B: isoproternol (ISO); group C: ISO + BCAA. The rats in groups A and...

pubmed.ncbi.nlm.nih.gov

 

[CastorTroy]

That is utter BS not backed up by science. instead of giving bad info based on nothing why don’t you view some of Dr Peter Attia.videos on protein needs as you age.

Are you serious? Peter Attia aka "covid vaccines save lifes, FULL STOP". That guy is a joke. All that research about cardiovascular health, yet hi did promote the poison and to this day he didn't say a word about the vaccices heart/cardiovascular damage scandal. Protein restriction may pose some valid discussion, but not because what that jerk says.

I'm personally fine with around 100gr/day, having at least 2-3x carbs. Carbs help to spare protein needs.

 

[Mr Joe]

Obviewsly someone that is 10kg won't need the same amount of protein as someone that is 40 or 90kg especially if the person is 80+ yo with less high metabolism to maintain and less testosterone to produce. The @haidut 1g prot per kg body weight seems accumulate. Even two people with same weight will have differents needs based on their life, metabolism and capacity to metabolize protein instead of creating ammonia. People claim that Peat diet is "restrictive" but if you listen to them basically BCAA is toxic, Meat is toxic, water is toxic, vitamin A is a poison, vitamin E is a poison, vitamin D is venom, vitamin K is not good, milk is bad for you, oranges are bad, liver is not good and toxic, copper is toxic. Anyway soon breathing will be toxic and lets pass all discussion around "sugar is addictive like cocaine". At the end we should eat soja and rice.

 

[GreekDemiGod]

Protein restriction was the end of Peat. His biggest mistake.

 

[LastingJoy]

Protein restriction was the end of Peat. His biggest mistake.

lolololol such a good même

 

[Highserotonin90]

@GTW What do you think about consuming protein only in the evening so that during the night the body has time to rebuild? while during the day carbohydrates and fats mainly.... did you say that mTOR is lowered with low proteins and AMPK prevails?

 

[ChiroGuru]

Listen to this:


View: https://humanperformanceoutliers.libsyn.com/size/5/?search=Layman+

 

[Samurai Drive]

@ChiroGuru

Thanks listening....

Layman is the guy I heard interviewed which prompted me to post this thread..

 

[ChiroGuru]

Bart Kay (hate him or love him) is probably right when he says 99% of the nutrition research is BS.

 

[TheCodez]

Bart Kay (hate him or love him) is probably right when he says 99% of the nutrition research is BS.

According to Sturgeon's Law, 99% of EVERYTHING is garbage.