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Aspirin has been shown to cause intestinal bleeding in some people and that's why they generally avoid aspirin. That can easily be remedied by switching to sodium salicylate or simply salicylic acid.
But this study is not about that. It actually shows that salicylate can be beneficial for the gut, at least in rats. The dose was 50mg/kg/day, with the HED being 7.14mg/kg. That will be around 500mg for a 70kg person.
"ZDF and Zucker lean (ZL) rats were administered a high-fat diet with or without SAL intervention, and their relative rates of diabetes were compared. Our results showed that all rats in the placebo group developed diabetes, whereas only 10% of the SAL-treated rats presented with impaired glucose tolerance (IGT). None of the latter progressed to diabetes. Relative to the untreated rats, SAL lowered plasma glucagon and insulin while improving insulin sensitivity and β-cell function. SAL may protect against hyperglycemia by increasing the microbial diversity, ameliorating gut dysbiosis, restoring intestinal epithelial cell connections, inhibiting endotoxin influx into the blood, and attenuating inflammation. Together, these findings suggest that SAL may be a candidate prophylactic therapy against diabetes. The protective role of SAL may be attributed to its ability to reduce intestinal inflammation and improve gut dysbiosis."
But this study is not about that. It actually shows that salicylate can be beneficial for the gut, at least in rats. The dose was 50mg/kg/day, with the HED being 7.14mg/kg. That will be around 500mg for a 70kg person.
Preventive Role of Salsalate in Diabetes Is Associated With Reducing Intestinal Inflammation Through Improvement of Gut Dysbiosis in ZDF Rats - PubMed
A safe and effective approach is needed to prevent and reduce the incidence of diabetes worldwide. The hypoglycemic efficacy of salicylic acid (salsalate, SAL), which has anti-inflammatory properties, has been empirically demonstrated in studies conducted at the Joslin Diabetes Center and...
pubmed.ncbi.nlm.nih.gov