Amazoniac
Member
- Effect of Dietary Copper on Intestinal Microbiota and Antimicrobial Resistance Profiles of Escherichia coli in Weaned Piglets
I would be mindful with chronic high doses (something that wasn't encouraged by the Bulgarian supercentenarian), it should be risky for various reasons.
- Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper
1x, 5x, 15x, 35x the usual intake (food consumption was similar). The extremes are what they call'd Control and High Cu groups throughout the publication.
I would be mindful with chronic high doses (something that wasn't encouraged by the Bulgarian supercentenarian), it should be risky for various reasons.
- Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper
"Ingested Cu(II) is readily reduced to Cu(I) by metalloreductase activity at the apical membrane of the gastrointestinal enterocytes (Ohgami et al. 2006; Ellingsen et al. 2015). Changes in absorption rate depending on the cellular copper status are likely related to the activity/efficiency of this enzyme and transporters like Ctr1. Higher copper exposure results in internalization of Ctr1 within the enterocytes, thereby reducing transport (Lonnerdal 2008; Van den Berghe and Klomp 2009). Ctr1 on the basement membrane side of the enterocyte can also transport copper into the enterocyte from the blood. Normal shedding of enterocytes (4-day average lifespan) into the gastrointestinal tract results in another source of elimination for the regulation of copper. Copper delivered to portal circulation is bound to histidine or serum proteins such as Diokine2-macroglobulin and albumin (Van den Berghe and Klomp 2009)."
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