He makes some Peaty points so I thought you guys might enjoy discussing it:
Gudru said:
You are one of the most high IQ members on here. Please just tell me about it . I'm a desperate teenager and I'm working hard on looksmaxxing. The future is now and I need to do what I can do to maximise everything.
x30001:
Well it's all really hard to understand at the start, but you'll eventually realise that real looksmaxing comes down to anti-aging, maximising your health, mental and physical and staying harmonious and never having to struggle on here again. Once you have a plan, your life will spiral upwards; appearance, attitude, success. They'll all carry support each other and push you really far.
Everyone here is so lazy and just want some magic "pill". Everything anyone suggests is just a quick-fix gimmick or something that just treats a symptom like a band aid would. Even that collagen guy just has no ******* clue what he's talking about.
The real way to looksmax extremely hard is through consistent hard work, exercise, working on everything. Perfecting your sleep. Understanding everything and executing your plan.
The real looksmaxing compound is called Nicotinamide Mononucleotide. It's a precursor to NAD+ in our body. Supplementation with NAD+ is impossible since the molecule is too large to enter our cells. NMN (Nicotinamide Mononeuclotide) is a small enough molecule to enter the outer membrane of our cells. A transporter called Slc12a8 carries into the inner membrane where it can bind to other NMN molecules and create NAD+ (Nicotinamide Adenine Dinucleotide). By age 20 we have 50% the NAD+ that we had in our body when we were in childhood. By age 50, we have 50% the amount we had when we were 20. That's the main thing. And you'll have to discover yourself why it's so important to looksmaxing and how you can literally exert more energy and do more work whilst not letting oxidative stress / inflammation affect your appearance just by having more NAD+ and learning how to balance your energy so that energy metabolism becomes seamless and doesn't age the mitochondria or cause DNA damage. There's so much more too it. Everything's linked. Looksmaxing, motivation, overcoming depression, getting smarter. Literally everything. It's all in our minds and bodies. No one on this forum even knows about BDNF (Brain Derived Neurotropic Factor), and how increasing levels of BDNF literally makes memory retention and the learning/problem solving process much much easier. Everything can be improved, anxiety/depression can be abolished. It's all possible, and there's so much more to everything. The rabbit hole is incredibly deep. Dr Joseph Mercola shared a few secrets on his YouTube and on some blogs and Google immediately deleted his videos and lowered his SEO for search engine results. All the "supplements" people talk about here are complete bull****. I've never heard anyone once talk about any supplement which can help activate the AMPK or sirtuin pathways. No one knows anything about autophagy. No one knows anything about NAD+ and why it's so important. Want to know how Kinobody has such big muscles and such perfect skin and hair without taking steroids? It's because he can workout harder by supplementing with NMN and balancing his energy by controlling the insulin/IGF1 signalling pathway, the AKT/AMPK pathway, the Forkhead Box protein pathway, etc. The depth to this is actually ******* insane and I just don't want to put the info out there since firstly no one will understand, and secondly, I want everyone else to just spin their wheels or make stupid decisions like take steroids or have surgeries. Only heard one user ever mention GHK-cu but even he didn't want to explain it for obvious reasons, and then he left the forum forever. I have a whole thread on how to keep AKT shut off and achieve skeletal muscle protein synthesis in without having any other anabolic pathways activated, whilst benefiting from AMPK. You can even bypass MTORC1 activation and achieve an extremely selective and more powerful form of S6 synthesis through SIRT1. Besides that, you can achieve protein synthesis through CASTOR1 and Sestrin2 and temporarily activate MTORC1 which will negatively regulate IRS once P70S6K is activated through the backdoor. Nobody understands why insulin is looksminning them and nobody even has a slightest clue what it is or what it does. But what I've told you doesn't even scratch the surface of real looksmaxing. Right now it's possible to reverse the cosmetic and neurodegenerative effects of aging. Big pharma don't like it as they want to keep profiting off their medication, but some people like Mercola, David Sinclair, Siim Land etc are in the know.
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Gudru
| Making my dreams come true |
Joined
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Messages
8,069
30 minutes ago
Holy ***t, should I buy it right away? This sounds insanely interesting and I"m really curious what else it could do.
+1Reply
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Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
30 minutes ago
Cancer Research Points to Key Unknowns about Popular “Antiaging” Supplements
The health promises of boosting an important metabolic molecule may be clouded by its possible role in promoting cancer-cell growth
www.scientificamerican.com
Thoughts on this?
+1Reply
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x30001
Ghk-cu maxing
Joined
Jan 10, 2019
Messages
2,065
10 minutes ago
Gudru said:
Holy ***t, should I buy it right away? This sounds insanely interesting and I"m really curious what else it could do.
x30001:
No don't buy it. You need to understand it's distinct purpose and how it reverses mitochondrial aging. You won't have skin issues if your skin cells are completely healthy, with perfect mitochondrial functioning in each cell. Skin cells, and EVERY cell. You should look into intermittent fasting and how fasting can activate AMPK, and all kinds of autophagy. You should also look into what autophagy is. Autophagy is a state your body can enter where it recycles old proteins and gets rid of useless cells, allowing new cells to grow and letting your body and brain work to the best of their abilities. There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have. It's just about taking a whole load of polyphenols and anti-oxidants through supplements. What we want is to achieve a heightened state of hormesis by constantly exposing ourselves to different kinds of mild oxidative stress, in which our body will upregulate its endogenous anti-oxidant defense systems. There's so many longevity/anti-aging pathways that most people living today have never activated. People just eat frequently and keep the insulin signalling cascade active, never allowing AMPK to become active. Anabolism/Catabolism basically refers to growth and self eating. The ultimate consequence of anabolism is death through growth of tumors, cancer cells, or any disease.. diabetes, getting obese (fat is inflammatory). The ultimate consequence of catabolism is death by starvation. Balancing anabolism and catabolism is so integral; but nobody ever puts themselves in a state or caloric/nutrient deprivation, because they're addicted to food and are unaware of the extreme health benefits of caloric restriction. When you restrict calories, your NAD+ also increases. Hunter Gatherers millions of years ago used to go for periods of fasting and feasting. They'd exercise in an energy deprived state, hunt their food, experience the benefits of adrenaline whilst using the AMPK fuel channel due to the absence of insulin signalling. Then they'd eat their food, usually meat or fish (no carbs, no refined bull**** sugars), they'd get all their minerals/vitamins, and they'd go to sleep, keeping a good circadian rhythm as we should as we are diurnal creatures. They'd expose themselves to cold and heat. Lighting bonfires at night to keep them warm (fire only inhibits melatonin by 2%). You can check how detrimental blue light exposure is at night. Even red light exposure inhibits melatonin production by 40%. We have cold-shock and heat-shock proteins in our body, which are very beneficial to health and longevity. All this is hardwired into our biology, from millions of years ago. But the world we live in wants us to eat 3 meals per day, keeping insulin signalling active all the time, and keeping us in an overly anabolic state. No wonder people are getting diabetes and cancer.
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Gudru
x30001
Ghk-cu maxing
Joined
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Messages
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7 minutes ago
Gudru said:
Cancer Research Points to Key Unknowns about Popular “Antiaging” Supplements
The health promises of boosting an important metabolic molecule may be clouded by its possible role in promoting cancer-cell growth
www.scientificamerican.com
Thoughts on this?
x30001:
Well it's not even possible to supplement with NAD, so even if you were to consume raw NAD powder, the molecule would be too large to enter your cell. You'd need to take NMN. NR can work too but is far less effective and converts to NAM (Nicotinamide Adenine Mononucleotide), so I'm really unsure how much NR actually converts to real intracellular NAD+ in the end.
Reply
Report
Reactions:
Gudru
Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
6 minutes ago
x30001 said:
No don't buy it. You need to understand it's distinct purpose and how it reverses mitochondrial aging. You won't have skin issues if your skin cells are completely healthy, with perfect mitochondrial functioning in each cell. Skin cells, and EVERY cell. You should look into intermittent fasting and how fasting can activate AMPK, and all kinds of autophagy. You should also look into what autophagy is. Autophagy is a state your body can enter where it recycles old proteins and gets rid of useless cells, allowing new cells to grow and letting your body and brain work to the best of their abilities. There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have. It's just about taking a whole load of polyphenols and anti-oxidants through supplements. What we want is to achieve a heightened state of hormesis by constantly exposing ourselves to different kinds of mild oxidative stress, in which our body will upregulate its endogenous anti-oxidant defense systems. There's so many longevity/anti-aging pathways that most people living today have never activated. People just eat frequently and keep the insulin signalling cascade active, never allowing AMPK to become active. Anabolism/Catabolism basically refers to growth and self eating. The ultimate consequence of anabolism is death through growth of tumors, cancer cells, or any disease.. diabetes, getting obese (fat is inflammatory). The ultimate consequence of catabolism is death by starvation. Balancing anabolism and catabolism is so integral; but nobody ever puts themselves in a state or caloric/nutrient deprivation, because they're addicted to food and are unaware of the extreme health benefits of caloric restriction. When you restrict calories, your NAD+ also increases. Hunter Gatherers millions of years ago used to go for periods of fasting and feasting. They'd exercise in an energy deprived state, hunt their food, experience the benefits of adrenaline whilst using the AMPK fuel channel due to the absence of insulin signalling. Then they'd eat their food, usually meat or fish (no carbs, no refined bull**** sugars), they'd get all their minerals/vitamins, and they'd go to sleep, keeping a good circadian rhythm as we should as we are diurnal creatures. They'd expose themselves to cold and heat. Lighting bonfires at night to keep them warm (fire only inhibits melatonin by 2%). You can check how detrimental blue light exposure is at night. Even red light exposure inhibits melatonin production by 40%. We have cold-shock and heat-shock proteins in our body, which are very beneficial to health and longevity. All this is hardwired into our biology, from millions of years ago. But the world we live in wants us to eat 3 meals per day, keeping insulin signalling active all the time, and keeping us in an overly anabolic state. No wonder people are getting diabetes and cancer.
Click to expand...
So what should I do then? The problem is I'm naturally lean, I used to be very skinny as a younger kid and I still wanna gain weight. Is intermittent fasting the only way to allow AMPK to become active?
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Gudru
| Making my dreams come true |
Joined
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Messages
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6 minutes ago
x30001 said:
Well it's not even possible to supplement with NAD, so even if you were to consume raw NAD powder, the molecule would be too large to enter your cell. You'd need to take NMN. NR can work too but is far less effective and converts to NAM (Nicotinamide Adenine Mononucleotide), so I'm really unsure how much NR actually converts to real intracellular NAD+ in the end.
What should we do instead?
+1Reply
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x30001
Ghk-cu maxing
Joined
Jan 10, 2019
Messages
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5 minutes ago
x30001 said:
There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have.
Meant to say *endogenous
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Gudru
x30001
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1 minute ago
Gudru said:
So what should I do then? The problem is I'm naturally lean, I used to be very skinny as a younger kid and I still wanna gain weight. Is intermittent fasting the only way to allow AMPK to become active?
x30001:
Just research and learn how everything works. AKT/AMPK are like a 2-way switch. They can't both be active at the same time; and AKT is activated through insulin. So yeah, AMPK is activated when in a fasted state. Supplements like Berberine are extremely powerful and speed up the process of entering AMPK and also target the Sirtuin pathway. People consider Berberine to be a better alternative to Metformin, even though Berberine is just a herbal supplement and not a pharmaceutical.
You should also look into telomeres and how they can be shortened and how you can prevent the shortening of them. There's a lot to digest and the rabbit-hole really is never ending.
Watch Siim Lands videos on YouTube, that's a good place to start and it's not that complicated or advanced.
Reply
Report Edit
Gudru said:
You are one of the most high IQ members on here. Please just tell me about it . I'm a desperate teenager and I'm working hard on looksmaxxing. The future is now and I need to do what I can do to maximise everything.
x30001:
Well it's all really hard to understand at the start, but you'll eventually realise that real looksmaxing comes down to anti-aging, maximising your health, mental and physical and staying harmonious and never having to struggle on here again. Once you have a plan, your life will spiral upwards; appearance, attitude, success. They'll all carry support each other and push you really far.
Everyone here is so lazy and just want some magic "pill". Everything anyone suggests is just a quick-fix gimmick or something that just treats a symptom like a band aid would. Even that collagen guy just has no ******* clue what he's talking about.
The real way to looksmax extremely hard is through consistent hard work, exercise, working on everything. Perfecting your sleep. Understanding everything and executing your plan.
The real looksmaxing compound is called Nicotinamide Mononucleotide. It's a precursor to NAD+ in our body. Supplementation with NAD+ is impossible since the molecule is too large to enter our cells. NMN (Nicotinamide Mononeuclotide) is a small enough molecule to enter the outer membrane of our cells. A transporter called Slc12a8 carries into the inner membrane where it can bind to other NMN molecules and create NAD+ (Nicotinamide Adenine Dinucleotide). By age 20 we have 50% the NAD+ that we had in our body when we were in childhood. By age 50, we have 50% the amount we had when we were 20. That's the main thing. And you'll have to discover yourself why it's so important to looksmaxing and how you can literally exert more energy and do more work whilst not letting oxidative stress / inflammation affect your appearance just by having more NAD+ and learning how to balance your energy so that energy metabolism becomes seamless and doesn't age the mitochondria or cause DNA damage. There's so much more too it. Everything's linked. Looksmaxing, motivation, overcoming depression, getting smarter. Literally everything. It's all in our minds and bodies. No one on this forum even knows about BDNF (Brain Derived Neurotropic Factor), and how increasing levels of BDNF literally makes memory retention and the learning/problem solving process much much easier. Everything can be improved, anxiety/depression can be abolished. It's all possible, and there's so much more to everything. The rabbit hole is incredibly deep. Dr Joseph Mercola shared a few secrets on his YouTube and on some blogs and Google immediately deleted his videos and lowered his SEO for search engine results. All the "supplements" people talk about here are complete bull****. I've never heard anyone once talk about any supplement which can help activate the AMPK or sirtuin pathways. No one knows anything about autophagy. No one knows anything about NAD+ and why it's so important. Want to know how Kinobody has such big muscles and such perfect skin and hair without taking steroids? It's because he can workout harder by supplementing with NMN and balancing his energy by controlling the insulin/IGF1 signalling pathway, the AKT/AMPK pathway, the Forkhead Box protein pathway, etc. The depth to this is actually ******* insane and I just don't want to put the info out there since firstly no one will understand, and secondly, I want everyone else to just spin their wheels or make stupid decisions like take steroids or have surgeries. Only heard one user ever mention GHK-cu but even he didn't want to explain it for obvious reasons, and then he left the forum forever. I have a whole thread on how to keep AKT shut off and achieve skeletal muscle protein synthesis in without having any other anabolic pathways activated, whilst benefiting from AMPK. You can even bypass MTORC1 activation and achieve an extremely selective and more powerful form of S6 synthesis through SIRT1. Besides that, you can achieve protein synthesis through CASTOR1 and Sestrin2 and temporarily activate MTORC1 which will negatively regulate IRS once P70S6K is activated through the backdoor. Nobody understands why insulin is looksminning them and nobody even has a slightest clue what it is or what it does. But what I've told you doesn't even scratch the surface of real looksmaxing. Right now it's possible to reverse the cosmetic and neurodegenerative effects of aging. Big pharma don't like it as they want to keep profiting off their medication, but some people like Mercola, David Sinclair, Siim Land etc are in the know.
Reply
Report
Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
30 minutes ago
Holy ***t, should I buy it right away? This sounds insanely interesting and I"m really curious what else it could do.
+1Reply
Report
Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
30 minutes ago
Cancer Research Points to Key Unknowns about Popular “Antiaging” Supplements
The health promises of boosting an important metabolic molecule may be clouded by its possible role in promoting cancer-cell growth
www.scientificamerican.com
Thoughts on this?
+1Reply
Report
x30001
Ghk-cu maxing
Joined
Jan 10, 2019
Messages
2,065
10 minutes ago
Gudru said:
Holy ***t, should I buy it right away? This sounds insanely interesting and I"m really curious what else it could do.
x30001:
No don't buy it. You need to understand it's distinct purpose and how it reverses mitochondrial aging. You won't have skin issues if your skin cells are completely healthy, with perfect mitochondrial functioning in each cell. Skin cells, and EVERY cell. You should look into intermittent fasting and how fasting can activate AMPK, and all kinds of autophagy. You should also look into what autophagy is. Autophagy is a state your body can enter where it recycles old proteins and gets rid of useless cells, allowing new cells to grow and letting your body and brain work to the best of their abilities. There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have. It's just about taking a whole load of polyphenols and anti-oxidants through supplements. What we want is to achieve a heightened state of hormesis by constantly exposing ourselves to different kinds of mild oxidative stress, in which our body will upregulate its endogenous anti-oxidant defense systems. There's so many longevity/anti-aging pathways that most people living today have never activated. People just eat frequently and keep the insulin signalling cascade active, never allowing AMPK to become active. Anabolism/Catabolism basically refers to growth and self eating. The ultimate consequence of anabolism is death through growth of tumors, cancer cells, or any disease.. diabetes, getting obese (fat is inflammatory). The ultimate consequence of catabolism is death by starvation. Balancing anabolism and catabolism is so integral; but nobody ever puts themselves in a state or caloric/nutrient deprivation, because they're addicted to food and are unaware of the extreme health benefits of caloric restriction. When you restrict calories, your NAD+ also increases. Hunter Gatherers millions of years ago used to go for periods of fasting and feasting. They'd exercise in an energy deprived state, hunt their food, experience the benefits of adrenaline whilst using the AMPK fuel channel due to the absence of insulin signalling. Then they'd eat their food, usually meat or fish (no carbs, no refined bull**** sugars), they'd get all their minerals/vitamins, and they'd go to sleep, keeping a good circadian rhythm as we should as we are diurnal creatures. They'd expose themselves to cold and heat. Lighting bonfires at night to keep them warm (fire only inhibits melatonin by 2%). You can check how detrimental blue light exposure is at night. Even red light exposure inhibits melatonin production by 40%. We have cold-shock and heat-shock proteins in our body, which are very beneficial to health and longevity. All this is hardwired into our biology, from millions of years ago. But the world we live in wants us to eat 3 meals per day, keeping insulin signalling active all the time, and keeping us in an overly anabolic state. No wonder people are getting diabetes and cancer.
Reply
Report
Reactions:
Gudru
x30001
Ghk-cu maxing
Joined
Jan 10, 2019
Messages
2,065
7 minutes ago
Gudru said:
Cancer Research Points to Key Unknowns about Popular “Antiaging” Supplements
The health promises of boosting an important metabolic molecule may be clouded by its possible role in promoting cancer-cell growth
www.scientificamerican.com
Thoughts on this?
x30001:
Well it's not even possible to supplement with NAD, so even if you were to consume raw NAD powder, the molecule would be too large to enter your cell. You'd need to take NMN. NR can work too but is far less effective and converts to NAM (Nicotinamide Adenine Mononucleotide), so I'm really unsure how much NR actually converts to real intracellular NAD+ in the end.
Reply
Report
Reactions:
Gudru
Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
6 minutes ago
x30001 said:
No don't buy it. You need to understand it's distinct purpose and how it reverses mitochondrial aging. You won't have skin issues if your skin cells are completely healthy, with perfect mitochondrial functioning in each cell. Skin cells, and EVERY cell. You should look into intermittent fasting and how fasting can activate AMPK, and all kinds of autophagy. You should also look into what autophagy is. Autophagy is a state your body can enter where it recycles old proteins and gets rid of useless cells, allowing new cells to grow and letting your body and brain work to the best of their abilities. There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have. It's just about taking a whole load of polyphenols and anti-oxidants through supplements. What we want is to achieve a heightened state of hormesis by constantly exposing ourselves to different kinds of mild oxidative stress, in which our body will upregulate its endogenous anti-oxidant defense systems. There's so many longevity/anti-aging pathways that most people living today have never activated. People just eat frequently and keep the insulin signalling cascade active, never allowing AMPK to become active. Anabolism/Catabolism basically refers to growth and self eating. The ultimate consequence of anabolism is death through growth of tumors, cancer cells, or any disease.. diabetes, getting obese (fat is inflammatory). The ultimate consequence of catabolism is death by starvation. Balancing anabolism and catabolism is so integral; but nobody ever puts themselves in a state or caloric/nutrient deprivation, because they're addicted to food and are unaware of the extreme health benefits of caloric restriction. When you restrict calories, your NAD+ also increases. Hunter Gatherers millions of years ago used to go for periods of fasting and feasting. They'd exercise in an energy deprived state, hunt their food, experience the benefits of adrenaline whilst using the AMPK fuel channel due to the absence of insulin signalling. Then they'd eat their food, usually meat or fish (no carbs, no refined bull**** sugars), they'd get all their minerals/vitamins, and they'd go to sleep, keeping a good circadian rhythm as we should as we are diurnal creatures. They'd expose themselves to cold and heat. Lighting bonfires at night to keep them warm (fire only inhibits melatonin by 2%). You can check how detrimental blue light exposure is at night. Even red light exposure inhibits melatonin production by 40%. We have cold-shock and heat-shock proteins in our body, which are very beneficial to health and longevity. All this is hardwired into our biology, from millions of years ago. But the world we live in wants us to eat 3 meals per day, keeping insulin signalling active all the time, and keeping us in an overly anabolic state. No wonder people are getting diabetes and cancer.
Click to expand...
So what should I do then? The problem is I'm naturally lean, I used to be very skinny as a younger kid and I still wanna gain weight. Is intermittent fasting the only way to allow AMPK to become active?
+1Reply
Report
Gudru
| Making my dreams come true |
Joined
Dec 16, 2018
Messages
8,069
6 minutes ago
x30001 said:
Well it's not even possible to supplement with NAD, so even if you were to consume raw NAD powder, the molecule would be too large to enter your cell. You'd need to take NMN. NR can work too but is far less effective and converts to NAM (Nicotinamide Adenine Mononucleotide), so I'm really unsure how much NR actually converts to real intracellular NAD+ in the end.
What should we do instead?
+1Reply
Report
x30001
Ghk-cu maxing
Joined
Jan 10, 2019
Messages
2,065
5 minutes ago
x30001 said:
There's an autophagic pathway called PDK2 which activates some of the most powerful exogenous anti-oxidants we have.
Meant to say *endogenous
Reply
Report
Reactions:
Gudru
x30001
Ghk-cu maxing
Joined
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Messages
2,065
1 minute ago
Gudru said:
So what should I do then? The problem is I'm naturally lean, I used to be very skinny as a younger kid and I still wanna gain weight. Is intermittent fasting the only way to allow AMPK to become active?
x30001:
Just research and learn how everything works. AKT/AMPK are like a 2-way switch. They can't both be active at the same time; and AKT is activated through insulin. So yeah, AMPK is activated when in a fasted state. Supplements like Berberine are extremely powerful and speed up the process of entering AMPK and also target the Sirtuin pathway. People consider Berberine to be a better alternative to Metformin, even though Berberine is just a herbal supplement and not a pharmaceutical.
You should also look into telomeres and how they can be shortened and how you can prevent the shortening of them. There's a lot to digest and the rabbit-hole really is never ending.
Watch Siim Lands videos on YouTube, that's a good place to start and it's not that complicated or advanced.
Reply
Report Edit