natedawggh
Member
- Joined
- Aug 24, 2013
- Messages
- 649
I've been reading about Hepcidin, a pro hormone discovered recently in 2000. It is the hormone that regulates Iron absorption and elimination in the body.
There is a lot of evidence via Ray Peat that most degenerative conditions involve excess iron, either directly or indirectly. Hepcidin is produced in great quantities in the presence of inflammation, but while Hepcidin prevents absorption of Iron it conversely prevents the excretion of it also.
So people like myself, with elevated Iron levels and difficulties losing unwanted weight (presenting with other health challenges, not just vanity since excess fat is basically a state of inflammation) may be suffering from a temporary immobilization of Iron, stuck in a paradoxical loop of corrosively high levels of Iron.
I've been taking a lot of B1 (thiamine), as it binds to Iron, and I think it might be helping though I haven't been able to confirm it with a lab test yet, and of course eat a diet rich in inflammation-reducing substances such as saturated fat, fruit, dairy, etc... but as even slight levels of endotoxin greatly exacerbate the inflammation response, it may be necessary for sufferers of Iron excess to have a more targeted and nuanced approach to reducing levels than just giving blood and taking vitamins. I have seen a post that mentioned tetracycline and other antibiotics binding iron (though cows can get it just for being alive, I cannot without an infectious disease get my doctor to give it to me).
Any more insight on this topic would be appreciated.
There is a lot of evidence via Ray Peat that most degenerative conditions involve excess iron, either directly or indirectly. Hepcidin is produced in great quantities in the presence of inflammation, but while Hepcidin prevents absorption of Iron it conversely prevents the excretion of it also.
So people like myself, with elevated Iron levels and difficulties losing unwanted weight (presenting with other health challenges, not just vanity since excess fat is basically a state of inflammation) may be suffering from a temporary immobilization of Iron, stuck in a paradoxical loop of corrosively high levels of Iron.
I've been taking a lot of B1 (thiamine), as it binds to Iron, and I think it might be helping though I haven't been able to confirm it with a lab test yet, and of course eat a diet rich in inflammation-reducing substances such as saturated fat, fruit, dairy, etc... but as even slight levels of endotoxin greatly exacerbate the inflammation response, it may be necessary for sufferers of Iron excess to have a more targeted and nuanced approach to reducing levels than just giving blood and taking vitamins. I have seen a post that mentioned tetracycline and other antibiotics binding iron (though cows can get it just for being alive, I cannot without an infectious disease get my doctor to give it to me).
Any more insight on this topic would be appreciated.