Such_Saturation
Member
- Joined
- Nov 26, 2013
- Messages
- 7,370
Energy management - a critical role in cancer induction?
alterations in management divert energy away from the construction and maintenance of stable complex structure into dynamic activity such as continuing replication, motility and migration, and architectural fluidity, ie. anaplasticity. This diversion would flow from the laws of thermodynamics which require energy to be dissipated (entropy). The review prompted a model (Fractal Entropy) whereby cellular entropic dissipation follows structure-independent fractal distributions rather than the linearly ordered, sequential pathways currently modelled for signal transduction.
Because replication, motility and architectural plasticity all actively dissipate more energy through kinetic activity than by structure-building in which energy becomes "locked in", these routes are preferred eventually generating a universal malignant phenotype independent of the types of mutations and pathways initially affected.
"Malignant" behaviour arises from disturbances which bias this fractal network to achieve maximum entropy.
Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis
Frequent epigenetic changes in malignant neoplasias are global hypomethylation and focal hypermethylation of multiple CpG island gene regulatory regions. Hypomethylated repeat sequences are decondensed. [...]
In other words, these multiple and widespread, in part invisible chromatin alterations are added as a kind of noise to the pre-existent fractal structure of the cancer cell nucleus, which gains complexity and thus a higher FD [Fractal dimension]. It is well known that the addition of noise to a fractal image may increase its FD.
Increasing fractal dimensions:
Blasts with lower R2 values [goodness-of-fit, a structure more close to the ‘ideal’ fractal], equivalent to accentuated "coarseness" of the chromatin pattern, which may reflect profound changes of the DNA methylation, indicated a poor prognosis.
in all studies an increasing FD (or decreasing goodness-of-fit) was an indicator of a worse prognosis.
Fractal dimensions decrease with age in normal rat hearts:
Since the quantum physicist E. Schroedinger wrote his book, Time's Arrow, people have often thought of life in terms of negentropy, going against the general tendency of entropy to increase, except for aging and death, which are seen as obeying a law of increasing entropy. But A. Zotin investigated organisms, rather than abstractions about electrons, and shows that aging involves a decrease in entropy, and a slowing of metabolism. The decrease of entropy with aging, according to his view, would be analogous to crystallization, a sort of progressive freezing.
When a nerve is stimulated, it releases energy suddenly, and much of this heat seems to be the result of a change of structure in the cytoplasm, since (in crustaceans' nerves, which can function at low temperature) during the resting recovery of the nerve, its temperature goes slightly below the ambient temperature, despite the release of some heat from the chemical changes of metabolism, stimulated by the nerve's activity.
When a physical change is endothermic, as the nerve's recovery is, that can be interpreted as an increase in overall entropy, as when a rubber band spontaneously contracts, and becomes cooler. - Ray Peat
So, cancer is an adaptation to permit further excitation when it should no longer be possible. Normal evolution focuses on the rest-stress progression to build structure and maximize communication (so smaller entities start working as one bigger entity with higher efficiency). Cancer is evolutionary DEvolution.
Fans of a certain stone-age lifestyle might want to reconsider their rationale.
alterations in management divert energy away from the construction and maintenance of stable complex structure into dynamic activity such as continuing replication, motility and migration, and architectural fluidity, ie. anaplasticity. This diversion would flow from the laws of thermodynamics which require energy to be dissipated (entropy). The review prompted a model (Fractal Entropy) whereby cellular entropic dissipation follows structure-independent fractal distributions rather than the linearly ordered, sequential pathways currently modelled for signal transduction.
Because replication, motility and architectural plasticity all actively dissipate more energy through kinetic activity than by structure-building in which energy becomes "locked in", these routes are preferred eventually generating a universal malignant phenotype independent of the types of mutations and pathways initially affected.
"Malignant" behaviour arises from disturbances which bias this fractal network to achieve maximum entropy.
Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis
Frequent epigenetic changes in malignant neoplasias are global hypomethylation and focal hypermethylation of multiple CpG island gene regulatory regions. Hypomethylated repeat sequences are decondensed. [...]
In other words, these multiple and widespread, in part invisible chromatin alterations are added as a kind of noise to the pre-existent fractal structure of the cancer cell nucleus, which gains complexity and thus a higher FD [Fractal dimension]. It is well known that the addition of noise to a fractal image may increase its FD.
Increasing fractal dimensions:
Blasts with lower R2 values [goodness-of-fit, a structure more close to the ‘ideal’ fractal], equivalent to accentuated "coarseness" of the chromatin pattern, which may reflect profound changes of the DNA methylation, indicated a poor prognosis.
in all studies an increasing FD (or decreasing goodness-of-fit) was an indicator of a worse prognosis.
Fractal dimensions decrease with age in normal rat hearts:
Since the quantum physicist E. Schroedinger wrote his book, Time's Arrow, people have often thought of life in terms of negentropy, going against the general tendency of entropy to increase, except for aging and death, which are seen as obeying a law of increasing entropy. But A. Zotin investigated organisms, rather than abstractions about electrons, and shows that aging involves a decrease in entropy, and a slowing of metabolism. The decrease of entropy with aging, according to his view, would be analogous to crystallization, a sort of progressive freezing.
When a nerve is stimulated, it releases energy suddenly, and much of this heat seems to be the result of a change of structure in the cytoplasm, since (in crustaceans' nerves, which can function at low temperature) during the resting recovery of the nerve, its temperature goes slightly below the ambient temperature, despite the release of some heat from the chemical changes of metabolism, stimulated by the nerve's activity.
When a physical change is endothermic, as the nerve's recovery is, that can be interpreted as an increase in overall entropy, as when a rubber band spontaneously contracts, and becomes cooler. - Ray Peat
So, cancer is an adaptation to permit further excitation when it should no longer be possible. Normal evolution focuses on the rest-stress progression to build structure and maximize communication (so smaller entities start working as one bigger entity with higher efficiency). Cancer is evolutionary DEvolution.
Fans of a certain stone-age lifestyle might want to reconsider their rationale.
