natedawggh
Member
- Joined
- Aug 24, 2013
- Messages
- 649
From a Ray Peat view of the organism (humans), it is generally viewed that all degenerative conditions are interrelated in one way or another. As is in my experience, mental and physical problems go hand in hand and rarely ever present singularly. The major themes of my struggles have been: depression/low energy, weight gain, thyroid and liver troubles, and severe insomnia.
I happened on a discussion here where Haidut mentioned Uridine. It piqued my curiosity and I have been doing some research into it. Uridine is common but only in low concentrations, and only exists in fresh food (meats especially). It, along with other nucleotides are vital to the life process, and the only Peat friendly source from which Uridine is found in high amounts is in human breast milk. This is interesting because the breast milk contains everything to sustain rapid and demanding human growth, and many of the other ingredients: calcium, protein, etc. we can attain from other sources once grown. Nucleotides we cannot get as easily.
In my reading I've come across some interesting studies on Uridine: it is commonly being used to treat psychiatric illnesses with great success. A recent study into bipolar treatment with Uridine found it successfully relieved conditions by sufferers: http://www.ksl.com/?sid=13451540
The medical establishment often regards mental and physical conditions as separate, but this is ridiculous because the mental part of ourselves is nothing but biology, and the same processes that govern the mind govern the rest of the body.
Uridine was also found in this rat study to completely suppress fatty liver conditions and restore hepatic (liver) mitochondrial activity. This study greatly interested me because I have very high triglycerides and a sluggish, fatty liver, and health truly does start and end with the liver. It also increased NAD+, which is regarded as a good thing. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605981/
Uridine also increased mitochondrial activity in HIV patients whose activity was suppressed by anti-viral drugs. The crux of Ray Peat's work is to increase the effectiveness and efficiency of mitochondria. http://www.natap.org/2006/HIV/072006_03.htm
Another of my conditions is very high cortisol: I developed a significant amount of abdominal fat and stretch marks (in areas that are not fat) which is an obvious, outward sign of very high cortisol. This study confirms that cortisol depletes Uridine, and the absence of cortisol increases Uridine: http://www.nrcresearchpress.com/doi/abs ... V94-EK25kc
This study also shows the different compositions at different times of day of the nucleotides in breast milk: https://www.borstvoeding.com/files/sanc ... otides.pdf
It is interesting to see that uridine concentration is at the highest in the evening and at night, the most stressful time of day for humans, and I have seen reports that Uridine helps or makes some people sleepy (this would be great for my insomnia!) but I also wonder if, like cortisol and melatonin, it might have negative effects with long term exposure. I'm guessing since it's in breast milk in high concentrations, it probably is more beneficial than not.
I've ordered some uridine (it's not commonly available but some brands do have it—I always avoid any supplements with silica in them). And will update this post with my experience. If anyone else has used Uridine please let us know if it has helped in any way!
I happened on a discussion here where Haidut mentioned Uridine. It piqued my curiosity and I have been doing some research into it. Uridine is common but only in low concentrations, and only exists in fresh food (meats especially). It, along with other nucleotides are vital to the life process, and the only Peat friendly source from which Uridine is found in high amounts is in human breast milk. This is interesting because the breast milk contains everything to sustain rapid and demanding human growth, and many of the other ingredients: calcium, protein, etc. we can attain from other sources once grown. Nucleotides we cannot get as easily.
In my reading I've come across some interesting studies on Uridine: it is commonly being used to treat psychiatric illnesses with great success. A recent study into bipolar treatment with Uridine found it successfully relieved conditions by sufferers: http://www.ksl.com/?sid=13451540
The medical establishment often regards mental and physical conditions as separate, but this is ridiculous because the mental part of ourselves is nothing but biology, and the same processes that govern the mind govern the rest of the body.
Uridine was also found in this rat study to completely suppress fatty liver conditions and restore hepatic (liver) mitochondrial activity. This study greatly interested me because I have very high triglycerides and a sluggish, fatty liver, and health truly does start and end with the liver. It also increased NAD+, which is regarded as a good thing. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605981/
Uridine also increased mitochondrial activity in HIV patients whose activity was suppressed by anti-viral drugs. The crux of Ray Peat's work is to increase the effectiveness and efficiency of mitochondria. http://www.natap.org/2006/HIV/072006_03.htm
Another of my conditions is very high cortisol: I developed a significant amount of abdominal fat and stretch marks (in areas that are not fat) which is an obvious, outward sign of very high cortisol. This study confirms that cortisol depletes Uridine, and the absence of cortisol increases Uridine: http://www.nrcresearchpress.com/doi/abs ... V94-EK25kc
This study also shows the different compositions at different times of day of the nucleotides in breast milk: https://www.borstvoeding.com/files/sanc ... otides.pdf
It is interesting to see that uridine concentration is at the highest in the evening and at night, the most stressful time of day for humans, and I have seen reports that Uridine helps or makes some people sleepy (this would be great for my insomnia!) but I also wonder if, like cortisol and melatonin, it might have negative effects with long term exposure. I'm guessing since it's in breast milk in high concentrations, it probably is more beneficial than not.
I've ordered some uridine (it's not commonly available but some brands do have it—I always avoid any supplements with silica in them). And will update this post with my experience. If anyone else has used Uridine please let us know if it has helped in any way!