metamorph
Member
I've been treating hypothyroidism successfully with T3/T4 Cynomel/Cynoplus for over a year. My most recent dose was 40mcg T3 & 80mcg of T4 daily.
However, 6 days ago I started taking Oxandrolone (Anavar) at 10mg and I became severely hyperthyroid, to the point of almost fainting. So, I backed the Oxandrolone dose down to 2.5-5mg and I'm still experiencing hyper and then hypo symptoms.
Instead of ditching the Oxandrolone experiment prematurely I'd like to give it another week to see what I can do to make it work.
Does anyone have any advice on adjusting thyroid accordingly when using Oxandrolone/non-aromatizing androgens?
"when you have a non aromatizing androgen you're going to reduce TBG, increase thyroid function (hyperthyroid) and lower TSH." - Video reference
"Oxandrolone on the other hand does not aromatize. The oxandrolone group showed a significant decrease in T4 and T3 resin uptake, with no change in TSH. Referring to Table 1 above, we see that the combination of low T4 and low T3 resin uptake is characteristic of hypothyroidism. This is the conclusion the authors arrived at as well, that the oxandrolone group experienced mild hypothyroidism. Again, as in the study by Deyssig & Weissel, even though T4 and T3 resin uptake were low relative to placebo the values fell within the normal range, making the diagnosis of “hypothyroidism” a relative one rather than a clinical one. Clinically all subjects would be classified as euthyroid. And as in the other studies the authors here concluded “these changes were most likely due to the effects of sex steroids on thyroid binding globulin (TBG).” The authors also observed that the Free T4 Index was higher in the oxandrolone group than either the placebo or testosterone groups." - Reference
When androgenic anabolic steroids are used in patients with thyroid disorders, clinicians should be aware that these agents may affect thyroid function tests. Specifically, thyroid-binding globulin levels may be decreased, resulting in lower total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however. - Source
For context; i'm experimenting with Oxandrolone for several reasons;
- Autoimmunity
"It has been known for almost 100 years that anabolic steroids such as testosterone (as well as nandrolone, oxandrolone, trenbolone, methenolone, etc) are highly effective in stopping almost immediately an "autoimmune" flare and often curing the entire condition for good." - @haidut post
- Recovery from glucocorticoid excess which Oxandrolone is used for
- Expedited Would healing and skin restructuring from life long skin-disease
- Rebuilding musculature/fitness after 2yrs disability
However, 6 days ago I started taking Oxandrolone (Anavar) at 10mg and I became severely hyperthyroid, to the point of almost fainting. So, I backed the Oxandrolone dose down to 2.5-5mg and I'm still experiencing hyper and then hypo symptoms.
Instead of ditching the Oxandrolone experiment prematurely I'd like to give it another week to see what I can do to make it work.
Does anyone have any advice on adjusting thyroid accordingly when using Oxandrolone/non-aromatizing androgens?
"when you have a non aromatizing androgen you're going to reduce TBG, increase thyroid function (hyperthyroid) and lower TSH." - Video reference
"Oxandrolone on the other hand does not aromatize. The oxandrolone group showed a significant decrease in T4 and T3 resin uptake, with no change in TSH. Referring to Table 1 above, we see that the combination of low T4 and low T3 resin uptake is characteristic of hypothyroidism. This is the conclusion the authors arrived at as well, that the oxandrolone group experienced mild hypothyroidism. Again, as in the study by Deyssig & Weissel, even though T4 and T3 resin uptake were low relative to placebo the values fell within the normal range, making the diagnosis of “hypothyroidism” a relative one rather than a clinical one. Clinically all subjects would be classified as euthyroid. And as in the other studies the authors here concluded “these changes were most likely due to the effects of sex steroids on thyroid binding globulin (TBG).” The authors also observed that the Free T4 Index was higher in the oxandrolone group than either the placebo or testosterone groups." - Reference
When androgenic anabolic steroids are used in patients with thyroid disorders, clinicians should be aware that these agents may affect thyroid function tests. Specifically, thyroid-binding globulin levels may be decreased, resulting in lower total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however. - Source
For context; i'm experimenting with Oxandrolone for several reasons;
- Autoimmunity
"It has been known for almost 100 years that anabolic steroids such as testosterone (as well as nandrolone, oxandrolone, trenbolone, methenolone, etc) are highly effective in stopping almost immediately an "autoimmune" flare and often curing the entire condition for good." - @haidut post
- Recovery from glucocorticoid excess which Oxandrolone is used for
- Expedited Would healing and skin restructuring from life long skin-disease
- Rebuilding musculature/fitness after 2yrs disability
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