Vaginal and nasal application of progesterone most effective ?

[Nik665]

https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=c593c1f754a2bccdf606bded7e51f49ba0626d0f

Nasal absorption of progesterone in women - PubMed

Absorption profiles were obtained from women following the administration of ointment containing 20, 30 and 40 mg of progesterone to the nasal mucosa. There were no significant differences in area-under-curves between groups receiving the drug in one nostril but when 40 mg doses were divided...

pubmed.ncbi.nlm.nih.gov

Why do people bother applying progesterone lotion on skin if maximal absorption is 10%. Studies show application through nose is number one followed by labia and vaginal application

 

[Dave Clark]

Makes sense, doesn't the nasal passages have quite a few blood vessels {where we get our nose bleeds from, lol}. So, wondering if massaging some of the progesterone products like Progest-E, CortiNon, etc. into the inside of the nose would be beneficial, and safe as well, or would it be too irritating?

 

[Nik665]

Makes sense, doesn't the nasal passages have quite a few blood vessels {where we get our nose bleeds from, lol}. So, wondering if massaging some of the progesterone products like Progest-E, CortiNon, etc. into the inside of the nose would be beneficial, and safe as well, or would it be too irritating?

I think several studies show it’s the best absorbed I would be careful to check excipients. For example lotions containing citric acid probably irritating. Tried oil the other day was good just feel a bit stuffy after for a few minutes

 

[Dave Clark]

I think several studies show it’s the best absorbed I would be careful to check excipients. For example lotions containing citric acid probably irritating. Tried oil the other day was good just feel a bit stuffy after for a few minutes

Good point. I think it is worth trying. Not many people knew about the naval application until a few years ago, and the nasal application may turn out to be even better. Having said that, the mucosal membranes can easily be irritated, so experimentation is warranted. I am going to give it a try using just a small amount, and see how it goes. Thanks for posting the info.