In Ask Your Herb Doctor's most recent interview with Ray Peat, Ray mentioned that some digestive bitters have a stabilizing effect on the mitochondria and can be quite helpful to multiple bodily functions. Another reason to use them for digestion and health benefits if you aren't already :)
He starts discussing it around the 48:00min mark
Cascara is nauseously bitter and as we know stimulates digestion greatly (you will be repainting the walls if taking more than a tip of a teaspoon).