WARNING! Old People Take Baths In Public Jacuzzis

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“Researchers at the University of Toronto's Faculty of Medicine have shown why anesthetics can cause long-term memory loss, a discovery that can have serious implications for post-operative patients.

Until now, scientists haven't understood why about a third of patients who undergo anesthesia and surgery experience some kind of cognitive impairment -- such as memory loss -- at hospital discharge. One-tenth of patients still suffer cognitive impairments three months later.
Anesthetics activate memory-loss receptors in the brain, ensuring that patients don't remember traumatic events during surgery. Professor Beverley Orser and her team found that the activity of memory loss receptors remains high long after the drugs have left the patient's system, sometimes for days on end.
Animal studies showed this chain reaction has long-term effects on the performance of memory-related tasks.
"Patients -- and even many doctors -- think anesthetics don't have long-term consequences. Our research shows that our fundamental assumption about how these drugs work is wrong," says Orser, a Professor in the Departments of Anesthesia and Physiology, and anesthesiologist at Sunnybrook Health Sciences Centre.
In the study -- led by PhD candidate Agnes Zurek -- the team gave healthy male mice a low dose of anesthetic for just 20 minutes and found that receptor activity was increased for a week afterwards. These results suggest the same effect can impact a patient's learning and memory during a time when they are receiving critical information about their care.
"There's a lot going on after surgery, which can alter our ability to think clearly. Loss of sleep, new environments and medications can all impact a patient's mental function. Anesthetics likely compound these issues," says Orser.”

Why anesthetics cause prolonged memory loss

Researchers have shown why anesthetics can cause long-term memory loss, a discovery that can have serious implications for post-operative patients.

www.sciencedaily.com

 

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“You might expect to get temporarily knocked out by general anesthesia during surgery, but new research has found that it may have lasting impacts on memory and cognition.


Researchers have already found evidence that anesthesia can increase risk of cognitive decline in the elderly, but a new study published today in the medical journal AnaesthesiaTrusted Source found evidence it may also affect people in middle age.

Anesthesia remains a mystery for doctors in many ways, despite its widespread use for over a century. Doctors still don’t understandanesthesia’s mechanism and how it works to help render patients unconscious.

In this study, researchers examined 964 participants with a mean age of 54 from the Wisconsin Registry for Alzheimer’s Prevention (WRAP).

The participants underwent two cognitive assessment tests over four years to see if one group was more likely to experience a cognitive decline or impaired memory.

Of the 670 participants with normal memory at the start of the study, those who had surgery during the study period were nearly twice as likely to show signs of “abnormal memory” than those who did not have surgery.

In total, 21 of the 114 people who underwent surgery developed abnormal memory by the end of the study.

This percentage was significantly higher than the 56 of 556 participants who developed abnormal memory and did not have surgery.

Overall, the team found that participants who had surgery were more likely to have more abnormal memory and issues with executive function, although the memory changes were fairly small.

“These data suggest that patients having surgery and anesthesia are more likely to experience impaired performance on neuropsychological tests of memory and executive function,” the study authors wrote.

They also found that having surgery was associated with a decline of immediate memory and verbal learning that was double the rate of decline among participants who did not have surgery.“

Anesthesia Impact on Memory

Researchers conclude that middle-aged people have a higher risk of memory loss and cognition decline after undergoing surgical anesthesia.

www.healthline.com

 

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“By inducing inflammation in pregnant mice, the researchers were able to produce a group of newborns with altered brain development that were protected against this early life memory loss.”

“While more work is required to understand how translatable these results are to humans, this study still marks an important advance in our understanding of the biology of forgetting.

"Different developmental brain states seem to result in altered rates of forgetting, which sheds light into the basic biology of forgetting and memory expression," Ryan said. "Our hope is that these findings will be useful not only for understanding basic questions of memory encoding and expression in everyday life, but also may be valuable for understanding what is happening in pathological forgetting such as Alzheimer's disease."’

Lost childhood memories can be restored using light, scientists discover

"The first results were very surprising," study author Tomas Ryan told Newsweek.

www.newsweek.com

 

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“Stress, exercise, and toxins cause a rapid increase in estrogen. Males often have as much estrogen as females, especially when they are tired or sick. Estrogen increases the brain’s susceptibility to epileptic seizures, and recent research shows that it (and cortisol) promote the effects of the “excitotoxins,” which are increasingly implicated in degenerative brain diseases.” -Ray Peat

Ray Peat, PhD: Quotes Relating to Exercise – Functional Performance Systems (FPS)

 

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“In the last century, Sechenov found that exercising one hand strengthens not only that hand, but also the other. Brain activity stimulates growth and alteration of tissues, such as muscles.” -Ray Peat

 

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“Lactic acid produced by intense exercise causes calcium loss from bone (Ashizawa, et al., 1997), and sodium bicarbonate increases calcium retention by bone.” -Ray Peat

 

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“The study found that the risk of death from all causes approximately doubled among women who tended to avoid the sun compared to women who got the greatest amount of UV exposure — including from both the sun and from tanning beds. The relationship was dose-dependent, the study found, meaning that the more sun a woman reported getting, the lower her risk of death. The protective effect of sun exposure remained significant, even after the study authors adjusted their figures for income, BMI, smoking history, and other factors that could account for their findings. “If that study’s findings are correct,” Zirwas says, “that means protecting yourself from ultraviolet light could have the same effect on your mortality as deciding to smoke a pack of cigarettes a day.” “That study,” he adds, “made me say, ‘Oh my God, there has to be a lot more to this story.’”

"...Heart disease is the most common cause of death in the United States, according to the U.S. Centers for Disease Control and Prevention (CDC). And that study from Sweden found that a drop in heart-disease deaths among the sun-exposed women was the most significant contributor to their lower mortality rates. It’s not the only study that has drawn ties between sun exposure and improved heart health. For decades, researchers have observed what they call the “winter cardiovascular disease phenomenon.”Both in the United States and in Europe, heart disease-related deaths peak in winter and bottom-out in summer, and the swing is not subtle. There’s also evidence that some markers of heart disease rise fairly consistently among people as their location slides farther north or south of the equator."’

Avoiding Sunlight May Be As Bad For Health As Smoking A Pack A Day

As most readers of this blog know, the current recommendations of the American Dermatology Association (ADA) call for pretty much no sun exposure of any skin areas unless those areas have been "protected" by sunscreen. The same recommendation applies to tanning beds and makes not distinction of...

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“Progesterone exerts a sleep induction or hypnotic effect and is a potent respiratory stimulant that has been associated to a decrease in the number of central and obstructive sleep apnea episodes in men. The literature also contains a substantial amount of data on the effect of apnea in women with obesity-hypoventilation during menopause. This review attempts to outline the specific role of progesterone in normal sleep and breathing as well as its possible therapeutic effects in the treatment of sleep-disordered breathing.“

Effects of progesterone on sleep: a possible pharmacological treatment for sleep-breathing disorders? - PubMed

Progesterone is present in a wide spectrum of biological activity within a variety of tissues. This hormone is also known to affect reproduction, sleep quality, respiration, mood, appetite, learning, memory and sexual activity. Progesterone exerts a sleep induction or hypnotic effect and is a...

pubmed.ncbi.nlm.nih.gov

 

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Q: I have no control over oils when eating out. What can I do to offset the harmful effects of polyunsaturated oils?

“A small amount of these oils won't kill you. It is the proportion of them in your diet that matters. A little extra vitamin E (such as 100 units per day) will take care of an occasional American restaurant meal. Based on animal studies, it would take a teaspoonful per day of corn or soy oil added to a fat-free diet to significantly increase our risk of cancer. Unfortunately, it is impossible to devise a fat-free diet outside of a laboratory. Vegetables, grains, nuts, fish and meats all naturally contain large amounts of these oils, and the extra oil used in cooking becomes a more serious problem.” -Ray Peat

 

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This was posted by @charlie innhis thread below…

“The caffeine in coffee protects against Alzheimer’s disease. A study in the Journal of Alzheimer’s Disease measured blood caffeine levels of patients over a 2-4 year period and found that caffeine/coffee intake is associated with a reduced risk of dementia or delayed-onset Alzheimer’s, particularly for those who already have mild cognitive impairment (MCI). Patients with MCI may be able to avoid, or delay, developing dementia by drinking several cups of coffee a day!”

The Many Benefits Of Drinking Coffee

The Many Benefits of Drinking Coffee http://blog.arkofwellness.com/the-many- ... ng-coffee/ Human consumption of coffee is said to go as far back as the 13th century. The most common tale involves an Ethiopian goat herder named Kaldi, who discovered that his goats would become lively long into...

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@snowboard111 write this below…

“Peat already talked about it in one his interview or articles (can't remember) about the elongated skulls that we're found in the tropics. Had something to do with the combinations of sugar from tropical fruits, the sun and the ocean and something else (all in all good factors). It was quite fascinating/intriguing.

• The problem of Alzheimer's disease as a clue to immortality - Part 2
  They are advancing a myth about human nature, so I will advance a counter-myth. At the time people were growing their large brains they lived in the tropics. I suggest that in this time before the development of grain-based agriculture, they ate a diet that was relatively free of unsaturated fats and low in iron--based on tropical fruits. I suggest that the Boskop skull from Mt. Kilimanjaro was representative of people under those conditions, and that just by our present knowledge of the association of brain size with longevity, they--as various "Golden Age" myths claim--must have had a very long life-span. As people moved north and developed new ways of living, their consumption of unsaturated fats increased, their brain size decreased, and they aged rapidly. Neanderthal relics show that flaxseed was a staple of their diet.”

Fruit Might Be Responsible For Our Bigger Brains

http://www.sciencemag.org/news/2017/03/eating-fruit-fuels-bigger-brains-primates I have suspected this for a while. Also, our inability to produce vitamin C is strong evidence that humans evolved eating massive amounts of fruit. To lose the ability to produce vitamin C, we had to be consuming...

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“Researchers have labored mightily to find more magic bullets, but they remain rare. For example, imatinib, brand name Gleevec, is “an especially effective treatment” for one type of leukemia, Stegenga says. But Gleevec has “severe adverse effects, including nausea, headaches, severe cardiac failure and delayed growth in children.” Most other forms of cancer, as well as heart disease, Parkinson’s, Alzheimer’s, arthritis, schizophrenia and bipolar disorder, lack cures or reliable treatments. Many “widely consumed” medications are “barely effective and have many harmful side effects,” Stegenga writes. Examples include drugs for high cholesterol, hypertension, type-two diabetes and depression. Stegenga warns readers not to stop taking prescribed medications without medical supervision, because abrupt cessation can be risky. But our health will improve and our costs shrink, Stegenga contends, if we resort to treatments much less often. As Hippocrates once said, “to do nothing is also a good remedy.”

"...There is no place I would rather be after a serious accident than in an intensive care unit. For a headache, aspirin; for many infections, antibiotics; for some diabetics, insulin—there are a handful of truly amazing medical intervention, many discovered between seventy and ninety years ago. However, by most measures of medical consumption—number of patients, number of dollars, number of prescriptions—the most commonly employed interventions, especially those introduced in recent decades, provide compelling warrant for medical nihilism."”

A Call For Medical Nihilism - To Do Nothing Is Also Good Medicine

To my greatest surprise, I stumbled upon yet another article in the Scientific American (SCIAM) that looked completely out of place in that publication. After all, SCIAM was (and continues to be) a bastion of official medicine and its articles often read more like drug company brochures than...

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“The researchers are beginning to think about how these results affect treatment. Earlier studies in mice showed that those fed emulsifiers -- which are often used as preservatives in processed foods -- had more bleeding in the brain, likely due to the way they disrupted the gut's bacterial network. The researchers now tell patients to avoid these preservatives...probiotics might seem like natural courses of treatment, they could change the bacterial balance in ways that lead to bigger problems. "This is more complicated than it appears," said Awad. However, he tells CA patients who have infections caused by gram-negative bacteria (such as urinary tract infections or prostatitis) to have them treated right away to avoid more potential brain lesions."”

Food Emulsifiers And Endotoxin (LPS) Cause Brain Bleeding

The study below is both ground-breaking and scary. Ground-breaking because it demonstrates yet another mysterious and potentially lethal disease - cavernous angioma (CA) - has a very simple explanation - endotoxin / LPS. Scary, because it refers to evidence that emulsifiers widely approved for...

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“It has recently become standard practice in most places to advise a person who is having a heart attack to immediately chew and swallow an aspirin tablet.

The same better-late-than-never philosophy can be applied to Alzheimer's disease, Parkinson's disease, and other degenerative nerve diseases. Aspirin protects against several kinds of toxicity, including excitotoxicity (glutamate), dopamine toxicity, and oxidative free radical toxicity. Since its effects on the mitochondria are similar to those of thyroid (T3), using both of them might improve brain energy production more than just thyroid. (By activating T3, aspirin can sometimes increase the temperature and pulse rate.) Magnesium, niacinamide, and other nerve protective substances work together.” -Ray Peat

Aspirin, brain, and cancer

Ray Peat

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“In a 1938 experiment (Brown, et al.) that intended to show the essentiality of unsaturated fats, a man, William Brown, lived for six months on a 2500 calorie diet consisting of sucrose syrup, a gallon of milk (some of it in the form of cottage cheese), and the juice of half an orange, besides some vitamins and minerals. The experimenters remarked about the surprising disappearance of the normal fatigue after a day's work, as well as the normalization of his high blood pressure and high cholesterol, and the permanent disappearance of his frequent life-long migraine headaches. His respiratory quotient increased (producing more carbon dioxide), as well as his rate of resting metabolism. I think the most interesting part of the experiment was that his blood phosphate decreased. In two measurements during the experimental diet, his fasting plasma inorganic phosphorus was 3.43 and 2.64 mg. per 100 ml. of plasma, and six month after he had returned to a normal diet the number was 4.2 mg/100 ml. Both the deficiency of the "essential" unsaturated fatty acids, and the high sucrose intake probably contributed to lowering the phosphate.” -Ray Peat

Phosphate, activation, and aging.

Recent publications are showing that excess phosphate can increase inflammation, tissue atrophy, calcification of blood vessels, cancer, dementia, and, in general, the processes of aging. This is especially important, because of the increasing use of phosphates as food additives.

raypeat.com

 

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“A diet that provides enough calcium to limit activity of the parathyroid glands, and that is low in phosphate and polyunsaturated fats, with sugar rather than starch as the main carbohydrate, possibly supplemented by niacinamide and aspirin, should help to avoid some of the degenerative processes associated with high phosphate: fatigue, heart failure, movement discoordination, hypogonadism, infertility, vascular calcification, emphysema, cancer, osteoporosis, and atrophy of skin, skeletal muscle, intestine, thymus, and spleen (Ohnishi and Razzaque, 2010; Shiraki-Iida, et al., 2000; Kuro-o, et al., 1997; Osuka and Razzaque, 2012). The foods naturally highest in phosphate, relative to calcium, are cereals, legumes, meats, and fish. Many prepared foods contain added phosphate. Foods with a higher, safer ratio of calcium to phosphate are leaves, such as kale, turnip greens, and beet greens, and many fruits, milk, and cheese. Coffee, besides being a good source of magnesium, is probably helpful for lowering phosphate, by its antagonism to adenosine (Coulson, et al., 1991).” -Ray Peat

 

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“"...For decades, statins have been heralded as the reliable heroes in the battle against heart disease, the leading cause of death in the United States and globally. However, this seemingly flawless reputation has been called into question. A new expert review suggests that long-term use of statins may be inadvertently aiding the enemy by accelerating coronary artery calcification instead of providing protection."”


“"...Statins impair the production of vitamin K, an essential vitamin in managing calcification, according to the review. Optimal vitamin K2 intake helps avoid plaque buildup of atherosclerosis—thickening or hardening of the arteries—and keeps calcification risk low. Coronary calcification happens when calcium accumulates in the walls of the coronary arteries that provide oxygen to the heart. This plaque buildup is a sign of early coronary artery disease, which can block blood flow and trigger a heart attack. A 2021 study published in the Kaohsiung Journal of Medical Sciences found a connection between statin use, coronary artery calcification, and vitamin K2 deficiency. The results shed light on how statins may spur arterial calcium accumulation by inhibiting vitamin K. The study’s findings were “in agreement with the existing evidence about positive association between statins and vascular calcification,” the authors added. Statins were also linked to increased calcification in a 2022 study published in Arteriosclerosis, Thrombosis, and Vascular Biology. However, the authors proposed that statins may encourage calcification by heightening inflammationrather than nutrient deficiency."“

The fraud unravels - statins cause, not prevent heart disease (CVD)

While the news that the statin fraud is finally being exposed is certainly good, it is sad that it took so many decades to admit to something so biochemically obvious. Namely, since statins interfere with the synthesis of mevalonic acid, as a consequence they also inhibit the synthesis of the...

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Aspirin as effective as pharma blood thinners

The study only looked at patients hospitalized for bone fractures, but I don't see why the results would be any different for any other condition and in any other setting (hospitalized or not). This probably at least the 10th study I have seen over the last few years demonstrating that humble...

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“And now, the controlled, randomized human study below demonstrated that vitamin K can indeed lower blood pressure consistently and the likely mechanism is the reversal of vascular stiffness, which the supplementation with vitamin K also achieved. Vascular stiffness is a symptom of vascular calcification, and vitamin K has been shown in numerous animal studies (and now human ones) to be able to prevent/reverse said calcification. So, considering vitamin K not only effectively lowers blood pressure but actually treats the underlying cause, it probably won't be long before vitamin K becomes a regulated drug in the West, mimicking its prescription-only status in many Asian countries. That would be the only way to prevent/limit the damage vitamin K can do to the multi-billion dollar CVD drug industry.”

“In post-hoc analyses, results showed that both pre/peri-menopausal and post-menopausal subjects taking MK-7 saw a significant decrease in dp-ucMGP plasma levels. In post-menopausal women, supplementation with MK-7 significantly attenuated vascular stiffness in post-menopausal women, and those with a high stiffness index saw significant improvements in vascular markers such as decreased blood pressure at brachialis, decreased blood pressure at carotid artery, increased distensibility coefficient and increased compliance coefficient. The study concluded that hormonal changes do in fact negatively impact the vasculature of post-menopausal women, and that MK-7 may attenuate these changes. However, more research is necessary to determine the mechanism by which MK-7 exerts these benefits. “This abstract strengthens the proof that K2 as MenaQ7 supports healthy cardiovascular function in aging women and can serve as an inexpensive tool for protecting heart health,” said Professor Leon Schurgers, lead researcher on the post-hoc analysis and chair of the Gnosis Vitamin K2 Scientific Advisory Committee, in a press release."“

Vitamin K reduces vascular stiffness, blood pressure in humans

The topic of vitamin K and blood pressure has been coming up for years among followers of Peat. He mentioned several cases, of which he had first-hand knowledge, where people managed to significantly and rapidly reduce their blood pressure by taking large doses of vitamin K. A number of...

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“When cells are stressed or dying, they take up calcium, which tends to excite the cells at the same time that it inhibits their energy production, intensifying their stress. A cramp or a seizure is an example of uncontrolled cellular excitation. Prolonged excitation and stress contribute to tissue inflammation and fibrosis.
Gross calcification generally follows the fibrosis that is produced by inflammation.
Arteries, kidneys, and other organs calcify during aging. At the age of 90, the amount of calcium in the elastic layer of an artery is about 35 times greater than at the age of 20. Nearly every type of tissue, including the brain, is susceptible to the inflammatory process that leads through fibrosis to calcification. The exception is the skeleton, which loses its calcium as the soft tissues absorb calcium.
These observations lead to some simplifying ideas about the nature of aging and disease.
Some people who know about the involvement of calcium in aging, stress, and degeneration suggest eating a low calcium diet, but since we all have skeletons, dietary calcium restriction cant protect our cells, and in fact, it usually intensifies the process of calcification of the soft tissues. Statistics from several countries have clearly shown that the mortality rate (especially from arteriosclerotic heart disease, but also from some other diseases, including cancer) is lower than average in regions that have hard water, which often contains a very large amount of either calcium or magnesium.
Many studies have shown that dietary calcium (or vitamin D, which increases calcium absorption) can have very important antiinflammatory effects.
About 25 years ago, David McCarron noticed that the governments data on diet and hypertension showed that the people who ate the most salt had the lowest blood pressure, and those who ate the least salt had the highest pressure. He showed that a calcium deficiency, rather than a sodium excess, was the most likely nutritional explanation for hypertension.” -Ray Peat

Calcium And Disease: Hypertension, Organ Calcification.

Calcium and Disease: Hypertension, organ calcification, & shock, vs. respiratory energy http://raypeat.com/articles/articles/calcium.shtml SOME CONTEXTS In biology and biochemistry, calcium is the substance most often studied, so it is significant that researchers still speak of a calcium...

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