I think It might even interfere with gonadal function at some point, sexual function for sure (I forwarded haidut's links to studies in one of the fap thread) , but the anti-depressant and anti-drive effects are not desireable for me, it's just numbing. Perhaps quantity is what matters. I'd definitely consider this as a potential problem when there's an obvious lack of motivation and perhaps honesty to look at what needs a change. An other possible marker would be unoptimal coordination (which you may have reported on video games). Again I don't know what you use nor what you experience but I'm just sharing one possibility among many.I'd rather like to keep the GABA up. I find it to have pretty potent health benefits. I figure increasing motivation is just a matter of increasing dopamine more. Perhaps mine isn't optimal. I have heard, though, that GABA decreases dopamine. I don't know how true that is, but I've also read supplements like tyrosine and caffeine have anti-GABA effects and they certainly feel like they do. So perhaps I have no choice but to lower GABA if I want to be more motivated. I really enjoy high GABA, from a personality standpoint, even. It seems to reduce the tendency I used to have to micromanage my life. My quality of life has, by extension, greatly improved. For this reason, I am pretty wary of decreasing GABA. I'd rather not go back down that road.