dopamine

  1. haidut

    Blocking serotonin, promoting dopamine may reverse cardiovascular disease (CVD)

    The claim in the title stems from the fact that bromocriptine - the drug used in the study below - is an approximate 5-HT antagonist while also being full agonist on several dopamine receptors. IMO, the study is a monumental success since CVD is largely considered a progressive condition, for...
    • haidut
    • Thread
    • blood pressure bromocriptine calcification cvd diabetes dopamine serotonin stiffness
    • Replies: 4
    • Forum: Scientific Studies
  2. Sapien

    “Dopamine fasting/detox” from a bioenergetic pov

    Currently there is a VERY popular (thousands of videos, some have 20+ millions views) trend in the self improvement space (Promoted by Huberman, Anna Lembke, and YouTubers (Hamza, SelfImprovementPill, Alex Becker, BetterThanYesterday, AfterSkool etc etc etc)) called “dopamine fasting”- I.e...
    • Sapien
    • Thread
    • dopamine dopamine detox dopamine fasting huberman instant gratification social media
    • Replies: 34
    • Forum: Mental Issues
  3. cs3000

    Dopamine raising effect of Carvacrol in the prefrontal cortex + hippocampus (oregano oil)

    ~150mg human equivalent of carvacrol Carvacrol: from ancient flavoring to neuromodulatory agent - PubMed by 7 days increased dopamine in the prefrontal cortex & hippocampus. increased serotonin a little too in the hippocampus, but you can see the dopamine effect is significantly bigger...
    • cs3000
    • Thread
    • carvacrol dopamine hippocampus oregano oil prefrontal cortex
    • Replies: 1
    • Forum: Scientific Studies
  4. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
    • NewACC
    • Thread
    • acetylcholine agonist antagonist bromocriptine caffeine coffee cyproheptadine dopamine serotonin tolerance
    • Replies: 4
    • Forum: Scientific Studies
  5. JamesGatz

    The HIGH DOPAMINE Thread - post pics/videos that make people HAPPY here

    This Thread will be dedicated to posting photos/videos that RAISE Dopamine and bring people Happiness It DOESN'T HAVE to be Funny - just something that makes people Happy - POST EM!
  6. haidut

    Progesterone, bromocriptine may treat autism

    A great new study, which, while genomic in character, inadvertently points the finger directly at estrogen and/or serotonin as causes of autism. After all progesterone's main role in the human organism is as an estrogen (and cortisol!) antagonist, while bromocriptine is one of the oldest...
    • haidut
    • Thread
    • allopregnanolone autism bromocriptine cortisol dopamine estrogen progesterone serotonin
    • Replies: 6
    • Forum: Scientific Studies
  7. haidut

    Dietary sugar can treat chronic depression

    Not much to comment on here, except to point out that the sugar "addiction" in depressed people has been recognized by medicine for at least 50 years and has always been treated as a co-morbidity of the depressed state, also in need of treatment. Doctors have been advising depressed patients to...
    • haidut
    • Thread
    • depression dopamine mental health mood reward sucrose sugar
    • Replies: 16
    • Forum: Scientific Studies
  8. TMCMac

    Alternatives to Nicotine / Lowering DHT to 3adiol

    Anyone know of other substances or ways to lower the conversion of DHT to 3adiol other than nicotine? I suspect this is one of my issues potentially after gaining a lot of weight so looking for ways to improve this as I work on lowering body fat. Nicotine helps give me that calm masculine...
    • TMCMac
    • Thread
    • 3adiol 5ar androgens calm dht dopamine mood nicotine
    • Replies: 1
    • Forum: Male Issues
  9. BlackMolasses

    Look for an alternative to coffee

    Coffee improves my well-being, but everything containing it has risen excessively in price in these times. I have tried nicotine with success, but nicotine gum is boring to consume. I live in a communist dictatorship so snus is illegal for some reason, cigarettes are legal but I don't want to...
  10. haidut

    Even very low-dose endocrine disruptors induce learned helplessness, anhedonia

    Not much to comment on this study, considering the mountains of literature already available on the topic of endocrine disruptors such as BPA/BPA/DEHP, except to point out that the results were obtained even with very low-dose exposure to the harmful chemicals. Another interesting finding was...
    • haidut
    • Thread
    • anhedonia bpa bps dehp depression dopamine endocrine disruptor feminization learned helplessness
    • Replies: 4
    • Forum: Scientific Studies
  11. Mauritio

    Cistanche / Echinachoside restores Tyrosine hydroxilase expression to normal in Parkinson's

    It has been established before that cistanche helps with Parkinson's and has a pro-dopamine effect. This study looked a bit deeper into the mechanism of it. In my opinion most noteworthy is the almost complete recovery of Tyrosine hydroxilase in tje sibstabtia nigra of Parkinson's mice...
  12. Hans

    Shilajit on testosterone, dopamine and sexual function

    https://men-elite.com/2022/05/13/shilajit-on-testosterone-dopamine-and-sexual-function/ What has been your experience with shilajit?
  13. haidut

    Dopamine agonists can treat anhedonia

    The title may sound obvious to many, but this study is one of the few to bring up the taboo topic of serotonin's role in symptoms of depression. The current dogma still holds that raising serotonin levels (or activating its receptors) is the most beneficial mechanism to treating depression and...
  14. NewACC

    (-) Benzofuranylpropylaminopropan is unknown peaty chemical?

    I had recently dug into the "depths" of pubmed and found two notable and rather unknown substances that could potentially become very peaty. In short, this is one of the most powerful neurotrophic substances I have seen. But it also is anticancer and anti-cortisol drug. The only negative can be...
    • NewACC
    • Thread
    • (-)bpap dopamine haidut longevity neuro-protective neurogenesis
    • Replies: 4
    • Forum: Scientific Studies
  15. umar

    Blocking seratonin with dopamine pathway unresolved would only make u gain weight

    its only when i started taking bromo with cypro that i felt so much better, its like seratonin increases when one is lacking of dopamine and it just fills the void, how do i resensitize my dopamine receptors after years of masturbating smtimes over 10 times aday as i cant be taking bromo for...
    • umar
    • Thread
    • dopamine
    • Replies: 4
    • Forum: Weight
  16. haidut

    Quinine - liquid product for R&D

    Just a placeholder thread for now, until I organize all the references I think would be interesting/relevant to post here. For now, a quote from Peat on a recent interview about quinine and inflammation/ACE2, a very long thread/discussion in regards to quinine's anti-serotonin effects, and some...
    • haidut
    • Thread
    • 5-ht ace2 angiotensin carnitine carnitine depletion dopamine fatty acid oxidation inflammation meldonium oct2 octn2 quinine serotonin
    • Replies: 98
    • Forum: IdeaLabs
  17. G

    Cold exposure increases baseline Dopamine levels - Huberman

    I was listening to this and it really got me thinking. What he is saying is anti Peat. View: https://youtu.be/QmOF0crdyRU https://link.springer.com/article/10.1007/s004210050065 https://www.glenlubbert.com/blog/2021/10/10/living-in-a-dopamine-nation
  18. Lokzo

    Vitamin C ESSENTIAL To Lower Prolactin?

    We have demonstrated that dopamine rapidly downregulates dopamine Ds receptors and that the physiological concentration of ascorbic acid prevents the D2 receptor downregulation. The ascorbic acid not only protects dopamine from oxidation (17, 22) but also potentiates the inhibitory action of...
  19. Hans

    Why TRT isn't working for you and what to do about it

    Although there might be a variety of reasons, this one should be part of the foundation to optimize any TRT protocol. https://men-elite.com/2021/12/06/why-trt-isnt-working-for-you/
  20. Brandin

    High dht and dopamine but low gaba?

    Hi I have succesfully increased my dht and lowered my estrogen alot. My stress is also ridicously low but for some reason I cant seem to increase gabaergic effects and feel huge difference when trying for example phenibut once. I think maybe my gaba receptors are very poor from inflammation...
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