niacinamide

  1. haidut

    Niacinamide May Be Able To Treat Both HIV And Tuberculosis

    Apparently, many human trials in the period 1945 - 1960 found it effective for tuberculosis. More recent trials (1990s and on) found it potentially effective for HIV. Effective human dose was 3g - 6g a day, with higher doses more effective for HIV...
  2. haidut

    Niacinamide Reverses Gastric Damage Caused By NSAID

    One of the reasons cited for NOT recommending regular aspirin use is its effect on the GI tract. Thus, substances that reduce or prevent this damage are in high demand. This study shows that niacinamide, in relatively low doses, not only prevents GI damage caused by NSAIDs but is more effective...
  3. haidut

    Niacinamide Prevents Development Of Diabetes Type I

    Both are human studies. The doses used were not that high either - only 250mg a day in the first study and 1200mg per square meter of body surface area in the second one. http://www.ncbi.nlm.nih.gov/pubmed/1286017/ http://www.ncbi.nlm.nih.gov/pubmed/16233932/ The second study would equate to...
  4. haidut

    Niacinamide Inhibits Cytotoxic Effects Of Methylene Blue

    Methylene blue (MB) in higher concetrations (5mmol and above) has been show to be cytotoxic and the mechanism is believed to be mainly through increases in lipid peroxidation. This study claims that niacinamide and some other anti-oxidants like vitamin E may mitigate those cytotoxic effects of...
  5. J

    Niacinamide Reduces Hyperparathyroidism

    This is only my second post on the forum. I've been researching hyperparathyroidism and hypercalcemia, and I've been coming across some good stuff that validates a lot of Peat's views. I came across this abstract a moment ago that claims that niacinamide (1080 mg per day) decreased serum...
  6. haidut

    Topical Absorption Of Caffeine, Aspirin And Niacinamide

    Another study, which looked at absorption of these Peat-approved substances through human skin. http://www.nature.com/jid/journal/v54/n ... 18185a.pdf Niacinamide absorption in acetone (the solvent used in the study) was only about 10%, however as per another human study I posted some time...
  7. haidut

    Benzodiazepines Are The New Wave Of Ppi Drugs

    Quite a few members of the forum have had experience with proton pump inhibitors (PPI) and have experienced first hand their horrible side effects. Here is a short sample of what people are experiencing while taking one of the well-known PPI drugs: http://www.askapatient.com/viewrating.a ...
    • haidut
    • Thread
    • article benzodiazepines niacinamide pharmaceutical drugs ppi
    • Replies: 36
    • Forum: Articles
  8. haidut

    Niacinamide For Type II Diabetes

    Ray has written about trials with niacinamide showing remission of even some type I diabetes cases. This study compared niacin to niacinamide for type II diabetes, and found niacinamide to be superior most likely due to stronger effect on mitochondrial biogenesis. Human dose equivalent would be...
  9. Velve921

    Niacinamide Dosage

    I am about to order niacidamide...how much should I take a day? I will be taking it because I am trying decrease serotonin production and improve my quality of sleep. Also, which foods are high in niacinamide?
  10. managing

    Niacinamide Problems: What Does It Say About My Health?

    I recently mentioned that I've had trouble with niacinamide making me drowsy. SuchSaturation suggested I try it with sugar. I did. It made me a little tired, which was solved by eating a meal shortly thereafter. Day two I repeated. A little tired. Some food. Better. By evening on day two...
  11. haidut

    Niacinamide Is Both A Serotonin And Tryptophan Antagonist

    I know this was discussed to a degree in another thread, but this study goes a bit further claiming that as being one of neurokynurenines niacin / niacinamide antagonizes the effects in the brain of both serotonin precursors and serotonin itself. http://www.ncbi.nlm.nih.gov/pubmed/15206724...
  12. M

    Phosphorous

    I had my phosphorous level checked, and it's a little high. Don't know how to do the ratio thing with the calcium, But here are my levels: :mrgreen: Calcium is 9.8 mg/dl Phosphorous 4.3 mg/dl Parathyroid is 15 pg/ml and magnesium is 2.0 mg/dl But on cronometer, now that I'm trying to...
    • mamaherrera
    • Thread
    • calcium diet niacinamide phosphorus study
    • Replies: 20
    • Forum: Minerals
  13. haidut

    Niacinamide / Nicotinamide Has A Glycogen-sparing Effect

    This may be one of its anti-stress mechanisms, in addition to its benzo similarities. http://www.ncbi.nlm.nih.gov/pubmed/2963642 "...The inhibitory action of nicotinic acid, nicotinamide, N-nicotinoyl-gamma-aminobutyric acid, NAD, NADH, NADP, and NADPH on the rabbit skeletal muscle glycogen...
  14. haidut

    Research On Niacinamide / Nicotinamide And Benzodiazepines

    I have been mentioning in many of my posts that there is quite a bit of research (mostly Russian) claiming that niacinamide (and to a lesser degree niacin) act like true benzodiazepine drugs. This comparison was my motivation for combining the caffeine with niacinamide. Here are some studies...
  15. haidut

    Niacinamide Lowers Fatty Acid Oxidation By Inhibiting SIRT1

    Many of you have probably heard of the resveratrol "miracle pill", which works by activating the SIRT1 "longevity gene". Well, the whole story is a classic example of medical fraud, and resveratrol was a miserable failure in clinical trials. This is not surprising to me as resveratrol has...
    • haidut
    • Thread
    • fatty acid oxidation niacinamide sirt1 sirtuins study
    • Replies: 20
    • Forum: Scientific Studies
  16. haidut

    Sirtuins And Life Extension

    Hi all, In the last couple of years there has been a lot of "noise" in the media about how the SIRT-family of genes can extend lifespan when activated by things like exercise or, preferably, by certain chemical compounds like resveratrol (which putatively acts on SIRT-1). Ray Peat has stated...
  17. haidut

    Niacinamide - A Potent Anti-anxiety Drug

    For those of you who are interested, and believe in the receptor theory (Ray Peat does not I think), here is some interesting info. Niacinamide in human doses of 1500mg - 3000mg daily is potent anti-anxiety drug similar in action to the benzodiazepine class of drugs like Diazepam, Valium, and...
  18. J

    Pregnenolone Or Niacinamide?

    Both these supplements arrived today. Which one should I start taking first?
    • jaa
    • Thread
    • niacinamide pregnenolone supplemental
    • Replies: 8
    • Forum: Supplements
  19. D

    Niacinamide Or Just Plain Niacin?

    Which is the one that can help with sleep/anxiety? Are they the same thing or not - 'just came from the health food store, left confused.
    • DMF
    • Thread
    • niacinamide supplemental vitamin b3
    • Replies: 158
    • Forum: B3/Niacinamide
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