pregnenolone

  1. haidut

    Pregnenolone Is A Potent Aldosterone Antagonist (antimineralocorticoid)

    Ray has written a number of articles on the hypertension, heart and kidney failure, eclampsia, and CVD in which he describes the central role of aldosterone in the pathogenesis of these conditions. Aldosterone antagonists (antimineralocorticoids - e.g. spironolactone, itself a pregnenolone...
    • haidut
    • Thread
    • aldosterone antagonist inhibitor mineralocorticoid pregnenolone
    • Replies: 10
    • Forum: Scientific Studies
  2. haidut

    Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging

    I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...
    • haidut
    • Thread
    • adrenals aging cortisol dhea dht estradiol gonads pregnenolone progesterone steroidogenesis steroids testosterone
    • Replies: 29
    • Forum: Scientific Studies
  3. haidut

    The Anabolic Effects Of Pregnenolone

    I posted a few studies showing pregnenolone has anti-cortisol and anti-estrogen effects, which make it anti-catabolic by definition. However, older studies referred to pregnenolone as an anabolic steroid and some of them examined its anabolic effects. While pregnenolone was not as potent as...
    • haidut
    • Thread
    • albumin anabolic anti-catabolic blood protein effects globulin pregnenolone protein synthesis
    • Replies: 82
    • Forum: Scientific Studies
  4. haidut

    The Anti-cortisol Mechanism Of Pregnenolone

    One of the recurring arguments on this forum is whether pregnenolone and progesterone (being technically precursor to the glucocorticoids) raise or lower cortisol levels, and whether they have effects opposing or promoting those of the glucocorticoids. The argument advanced by a few people here...
    • haidut
    • Thread
    • antagonist cell cortisol glucocorticoid nucleus pregnenolone receptor translocation
    • Replies: 12
    • Forum: Scientific Studies
  5. haidut

    Pregnenolone (and DHEA) May Protect From Heart Disease

    In some of his recent emails to people Ray recommended pregnenolone as a substance that lowers prostaglandins and inflammation. This mechanism of action also happens to be the officially proposed one for the benefits in heart disease seen with aspirin use. I was looking for the studies to...
    • haidut
    • Thread
    • cvd dhea dhea-s heart disease pregnenolone pregnenolone sulfate protective trpm3
    • Replies: 0
    • Forum: Scientific Studies
  6. haidut

    Pregnenolone As A Treatment For Loneliness

    I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...
    • haidut
    • Thread
    • 5a-dhp 5α-dhp 5α-dihydroprogesterone allopregnanolone depression hpa loneliness mental health pregnenolone progesterone social isolation
    • Replies: 52
    • Forum: Scientific Studies
  7. haidut

    Optimal Dose Of Pregnenolone For Androgen Synthesis

    There was a recent discussion about high dose pregnenolone on the forum and some people sent Peat my comments that high dose pregnenolone can inhibit androgen synthesis. Peat replied that he has not seen such effects, but did not directly speak against the idea. Privately, I got quite a few...
    • haidut
    • Thread
    • androgen androstenedione concentration dhea optimal pregnenolone progesterone synthesis topical
    • Replies: 136
    • Forum: Scientific Studies
  8. X3CyO

    Are Pregnenolone And Its Metabolites Minor Stress Hormones?

    I understand the difference between peat, and mainstream science in regards to what is good and bad hormonally, but now entering the gray area. Cortisol is good in inconsistent acute amounts, but not chronic, while progesterone is its complete opposite. If taken in excess, progesterone and...
  9. Koveras

    The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men

    https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract
    • Koveras
    • Thread
    • allopregnanolone androsterone anxiety depression pregnenolone progesterone steroids testosterone
    • Replies: 13
    • Forum: Scientific Studies
  10. haidut

    Raising Serum Androgens Using DHEA, Pregnenolone, And Vitamin K

    User testimony (4/26/2021): My Experiences With Raising Androgens Log (Pansterone, k2, magnoil) Many people use supplements like DHEA, pregnenolone, and progesterone with the goal of raising their androgens and lowering estrogen. While this approach works for raising tissue levels of steroids...
    • haidut
    • Thread
    • androgens androstenedione aromatase dhea dht gonads hypogonadism menaquinone pregnenolone serum steroidogenesis synthesis testosterone vitamin k vitamin k2
    • Replies: 444
    • Forum: Scientific Studies
  11. haidut

    Stress Leads To Lower Dopamine And More Drinking

    The study was really on alcohol consumption what affects it. It has been known since the 1960s that people drink more when under stress but to this day mainstream medicine denies that there is a causative link between stress and substance abuse. I posted a few studies showing that "addicts" have...
    • haidut
    • Thread
    • addiction alcohol alcoholism cortisol crh dopamine drinking ethanol gaba glucocorticoid pregnenolone
    • Replies: 64
    • Forum: Scientific Studies
  12. H

    PREGNENOLONE COMBINED WITH THEANINE FOR ANHEDONIA

    Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double... - PubMed - NCBI (Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia) I have...
  13. haidut

    Pregnenolone & Progesterone Are Both Agonists Of The Androgen Receptor

    Patients with prostate cancer are often treated with a combination of therapies such as 5-AR inhibitors to reduce production of DHT as well as other enzyme inhibitors to reduce conversion of DHEA into other downstream androgens. From the point of view of mainstream "treatment" for prostate...
    • haidut
    • Thread
    • androgen agonist androgenic growth nucleus pregnenolone progesterone prostate study translocation
    • Replies: 24
    • Forum: Scientific Studies
  14. marcar72

    Good Pregnenolone Write Up

    Here's a good write up on pregnenolone and mental function. It mentions Ray Peat in about the middle. Pregnenolone and Mental Function Energizing, Anti-stress Benefits Pro-memory Effects Mood Elevation Enjoy!!
  15. haidut

    Pregnenolone Activates The Glycine Receptor

    This mechanism of pregnenolone is one of the proposed methods through which it enhances neurogenesis, memory, mood and even motor function. Low doses pregnenolon improve sleep quality and are even mildly sedating, which may also be due to the activation of the glycine receptor. Subunit-specific...
    • haidut
    • Thread
    • agonist cognition glycine memory mood pregnenolone receptor relaxation sleep
    • Replies: 3
    • Forum: Scientific Studies
  16. haidut

    PPI Drugs (anti GERD) Powerfully Inhibit Steroidogenesis

    I have always been suspicious of PPI drugs. There are many reasons for it, including the falsified clinical trial data to conceal increased risk of gastric cancer, the idiotic premise that gastric acid increases with age, the kidney failure side effects, and the calcium/magnesium depletion being...
    • haidut
    • Thread
    • cholesterol gerd inhibition inhibitor ppi pregnenolone side cleavage side cleavage enzyme steroidogenesis steroids
    • Replies: 3
    • Forum: Scientific Studies
  17. P

    Add-on Pregnenolone With L-Theanine To Antipsychotic Therapy Relieves Negative And Anxiety Symptoms

    Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double... - PubMed - NCBI Abstract AIMS: Pregnenolone (PREG) and L-Theanine (LT) have shown ameliorative effects on various schizophrenia symptoms. This...
    • paymanz
    • Thread
    • anxiety mental health pregnenolone schizophrenia study theanine
    • Replies: 0
    • Forum: Scientific Studies
  18. haidut

    The Myth Of Pregnenolone Steal

    I think this is a very persistent myth and one that is reigning supreme on all forums except this one. Even here, we occasionally get challenged and statements referring to this flawed idea. Here is something that will hopefully clarify why the steroid "steal" is a flawed idea. Among the more...
    • haidut
    • Thread
    • cortisol dhea hypothyroidism inflammation pregnenolone pregnenolone steal steal stress
    • Replies: 9
    • Forum: Scientific Studies
  19. haidut

    Recovering Steroidogenesis Inhibited By Alcohol And Drugs

    As many of you know, drugs like Finasteride are really bad not only because they cause a variety of CNS effects as a result of inhibiting 5-AR, but also because they systemically inhibit the entire steroid synthesis cascade. Toxins and alcohol do the same and currently there is no approved...
  20. haidut

    Pregnenolone May Protect Cognition From Damage By Stress

    The study was actually on how stress damages cognition, and based on another study I posted and the drug used in the study to block the effects of stress I inferred that pregnenolone would work just as well. The study discovered that the release of CRF / CRH as part of the stress response is...
    • haidut
    • Thread
    • cognition crf crh dementia depression pregnenolone schizophrenia stress
    • Replies: 2
    • Forum: Scientific Studies
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